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Genomic Deletions Drive Development of Melanoma Drug Resistance

Melanoma is the deadliest form of skin cancer. With global incidence rates rising, new, more effective treatments are necessary to alleviate the health burden of the disease. Important advances in recent years include doctors using genetic tests to look for specific mutations they can target for more personalised, effective treatment.

15 Apr 2024

How Glucocorticoids Quell Inflammation

Cortisone and other related glucocorticoids are extremely effective at curbing excessive immune reactions.

13 Apr 2024

Leveraging the Materiobiology Approach to Design Biomaterials for Aged Bone Repair

In the elderly, a multitude of factors contribute to diminished bone regeneration capabilities, including a reduction in the self-renewal and differentiation abilities of mesenchymal stem cells, an excessive accumulation of inflammatory signals, compromised blood vessel regeneration capacity, an imbalance between bone anabolism and catabolism, and inadequate bone innervation.

13 Apr 2024

Deciphering the Significance of m6A RNA Modification in HIV-1 Genome

A chemical modification in the HIV-1 RNA genome whose function has been a matter of scientific debate is now confirmed to be key to the virus's ability to survive and thrive after infecting host cells, a new study has found.

13 Apr 2024

Unraveling the Molecular Mechanisms of DNA Entanglement Resolution

Picture in your mind a traditional "landline" telephone with a coiled cord connecting the handset to the phone.

12 Apr 2024

Different Chromosomes Found to Have Separate End-Specific Telomere-Length Distributions

We depend on our cells being able to divide and multiply, whether it's to replace sunburnt skin or replenish our blood supply and recover from injury.

12 Apr 2024

Understanding Prostate Cancer Disparities Through Proteogenomics

Certain proteogenomic signatures in the prostate cancers of men of African and European ancestries were associated with higher risk of metastasis and/or recurrence of the disease, according to a study presented at the American Association for Cancer Research (AACR) Annual Meeting 2024, held April 5-10.

10 Apr 2024

Precision Combination Therapy Better Controls High-Risk Subtypes of B-ALL in Mouse Models

Despite having an overall survival rate of 94%, B-cell acute lymphoblastic leukemia (B-ALL), the most common childhood cancer, can prove challenging to treat, with survival among relapsed or resistant cases falling between 30-50%.

9 Apr 2024

New Method Revolutionizes Assessment of Ferroptosis-Targeting Enzymes

New research could pave the way to develop cancer drugs targeting an enzyme that inhibits ferroptosis, a type of cell death.

8 Apr 2024

Researchers Uncover the FACT-ETS-1 Antiviral Response Pathway

By focusing on a poxvirus protein, a team led by UT Southwestern Medical Center scientists has discovered an antiviral immune pathway that broadly fights a wide variety of viruses.

4 Apr 2024

Unveiling the Potential of the New Antibiotics Against Bacteria

A novel family of antibiotics with strong action against bacteria resistant to many drugs has been found by Uppsala University researchers, and they have demonstrated that this class of antibiotics may treat bloodstream infections in mice.

2 Apr 2024

Groundbreaking AI Framework Revolutionizes Drug Discovery

A transformative study published in Health Data Science, a Science Partner Journal, introduces a groundbreaking end-to-end deep learning framework, known as Knowledge-Empowered Drug Discovery, aimed at revolutionizing the field of drug discovery.

1 Apr 2024

Enzymatic Cocktail Outperforms Antibiotics Against Mycobacteria, Including TB

A recent study published in Microbiology Spectrum, a journal of the American Society for Microbiology, demonstrates that an enzymatic cocktail has the capability to eliminate various mycobacterial species of bacteria, including those responsible for tuberculosis.

28 Mar 2024

AI Predicts Multiple Protein Shapes, Boosting Drug Development

By understanding protein dynamics and functions, a group of academics at Brown University have devised a method for quickly predicting various protein configurations using machine learning.

28 Mar 2024

To Bolster Global Efforts in Combating Antibiotic-Resistant Bacteria KFSH&RC Scientists Discover New Bacteria Species: Riyadhensis

In a ground-breaking development, scientists at King Faisal Specialist Hospital and Research Centre (KFSH&RC) have identified a new species of bacteria, referred to as "Stenotrophomonas Riyadhensis" through the application of whole-genome sequencing (WGS) technology.

27 Mar 2024

The Influence of sRNA on Gut Pathogen Drug Susceptibility

A significant breakthrough in understanding how gut bacteria adapt to their environment.

26 Mar 2024

Nature-Inspired Approach Accelerates Folding of Cysteine-Rich Peptides for Drug Discovery

Certain types of peptides and microproteins for drug discovery research can be made more efficiently and quickly using a reaction solvent that helps mimic nature's way.

25 Mar 2024

Multi-Tailed Strucrure Expands the Horizons of mRNA Therapeutics

Messenger RNA (mRNA) made its big leap into the public limelight during the pandemic, thanks to its cornerstone role in several COVID-19 vaccines

25 Mar 2024

Latest CRISPR-Cas Gene Editing Can Eliminate All Traces of HIV Virus From Infected Cells

New research presented early ahead of this year's European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2024, Barcelona, 27-30 April) from a team of researchers in the Netherlands shows how the latest CRISPR-Cas gene editing technology can be used to eliminate all traces of the HIV virus from infected cells in the laboratory, raising hopes of a cure.

20 Mar 2024

Drug Candidates Show Promise to Reverse HIV's Ability to Escape Immune System Detection

University of Pittsburgh School of Medicine scientists have identified drug candidates that show promise to reverse the ability of HIV to escape detection by the immune system.

20 Mar 2024

Drugs News and Research

Genomic Deletions Drive Development of Melanoma Drug Resistance

How Glucocorticoids Quell Inflammation

Leveraging the Materiobiology Approach to Design Biomaterials for Aged Bone Repair

Deciphering the Significance of m6A RNA Modification in HIV-1 Genome

Unraveling the Molecular Mechanisms of DNA Entanglement Resolution

Different Chromosomes Found to Have Separate End-Specific Telomere-Length Distributions

Understanding Prostate Cancer Disparities Through Proteogenomics

Precision Combination Therapy Better Controls High-Risk Subtypes of B-ALL in Mouse Models

New Method Revolutionizes Assessment of Ferroptosis-Targeting Enzymes

Researchers Uncover the FACT-ETS-1 Antiviral Response Pathway

Unveiling the Potential of the New Antibiotics Against Bacteria

Groundbreaking AI Framework Revolutionizes Drug Discovery

Enzymatic Cocktail Outperforms Antibiotics Against Mycobacteria, Including TB

AI Predicts Multiple Protein Shapes, Boosting Drug Development

To Bolster Global Efforts in Combating Antibiotic-Resistant Bacteria KFSH&RC Scientists Discover New Bacteria Species: Riyadhensis

The Influence of sRNA on Gut Pathogen Drug Susceptibility

Nature-Inspired Approach Accelerates Folding of Cysteine-Rich Peptides for Drug Discovery

Multi-Tailed Strucrure Expands the Horizons of mRNA Therapeutics

Latest CRISPR-Cas Gene Editing Can Eliminate All Traces of HIV Virus From Infected Cells

Drug Candidates Show Promise to Reverse HIV's Ability to Escape Immune System Detection

Expert Insights: HiMedia Labs on Advancing Nucleic Acid Extraction Across Industries

Quorum Bio: Where Synthetic Biology Meets Sustainable Farming

Diagnostic Biochips: Pioneering Brain Research Tools for the Future

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