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Metabolic Insights into Immune Cell Activation and Response

Researchers from Children's Hospital of Philadelphia identified a key metabolite in cells that helps direct immune responses and explains at a single cell level why immune cells that most efficiently recognize pathogens, vaccines, or diseased cells grow and divide faster than other cells.

18 Mar 2024

Transcriptome Profiling Reveals Age-Associated Changes in the Human Brain

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 5, entitled, "Genome-wide transcriptome profiling and development of age prediction models in the human brain."

18 Mar 2024

Exploring the Link Between Gut Health and Effective Milk Allergy Treatment

Exploring the Link Between Gut Health and Effective Milk Allergy Treatment At the RIKEN Center for Integrative Medical Sciences in Japan, researchers under the direction of Hiroshi Ohno have found a connection between gut microbiota and the effectiveness of oral immunotherapy for milk allergies.

15 Mar 2024

DNA Origami Revolutionizes Cancer Immunotherapy: The DoriVac Breakthrough

Therapeutic cancer vaccines are a form of immunotherapy in the making that could not only destroy cancer cells in patients, but keep a cancer from coming back and spreading.

15 Mar 2024

Dual-Target CAR T Cell Therapy Shows Promise Against Recurrent Glioblastoma

Targeting two brain tumor-associated proteins-;rather than one-;with CAR T cell therapy shows promise as a strategy for reducing solid tumor growth in patients with recurrent glioblastoma (GBM), an aggressive form of brain cancer, according to early results from the first six patients treated in an ongoing Phase I clinical trial led by researchers from the Perelman School of Medicine at the University of Pennsylvania and Penn Medicine's Abramson Cancer Center.

14 Mar 2024

Newly Discovered Bacterial Species Shed Light on Antibiotic Resistance

Antibiotic-resistant infection is projected to catch up to cancer as the leading cause of death by 2050, making understanding and limiting the spread of antibiotic-resistant bacteria a priority worldwide.

1 Mar 2024

Tandem Repeat Expansions Linked to Cardiomyopathy Risk, Reveals Study

In the first study to use whole genome sequencing to examine tandem repeat expansions in heart conditions, scientists at The Hospital for Sick Children (SickKids) have laid the groundwork for early detection of and future precision therapies for cardiomyopathy.

28 Feb 2024

Novel Antibiotic Discovery: Harnessing Energy Compounds to Combat Bacterial Infections

About a decade ago, researchers in UC Santa Barbara chemistry professor Guillermo Bazan's lab began to observe a recurring challenge in their research: Some of the compounds they were developing to harness energy from bacteria were instead killing the microbes.

22 Feb 2024

Study Reveals Gut Microbiome's Influence on Premature Aging in Chronic HIV Patients

The Wistar Institute's associate professor Mohamed Abdel-Mohsen, Ph.D., has demonstrated, with his lab and collaborators, a connection between viral damage to the gut and premature biological aging.

22 Feb 2024

The Role of Associative Memory in Spatial Navigation

Human lives revolve around spatial navigation and spatial memory. Without these skills, it would be extremely difficult to remember the past and to navigate the environment. But understanding the neural underpinnings of spatial memory is still quite incomplete.

19 Feb 2024

GWAS Identifies Key Genetic Factors for Lassa Fever Susceptibility and Severity

While combing through the human genome in 2007, computational geneticist Pardis Sabeti made a discovery that would transform her research career.

9 Feb 2024

Accelerating Genetic Research - The Story Behind One-pot DTECT

Dr Pierre Billon, PhD, grew increasingly frustrated with the lengthy turnaround times and high costs associated with obtaining genetic analysis from specialized private laboratories

8 Feb 2024

Prefrontal Neurons’ Cascade of Phonetic Representations

A new study led by researchers at Massachusetts General Hospital (MGH) uses sophisticated brain recording techniques to show how neurons in the human brain cooperate to enable people to plan words for speech and then produce them verbally.

5 Feb 2024

RNA-Seq Unveils Molecular Subtypes for Tailored Pediatric B-ALL Treatment

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, representing more than 30% of all pediatric cases.

31 Jan 2024

Cholangiocarcinoma: New Organ-On-Chip Aims at Accelerating Research and Personalized Medicine

It is only a few centimeters in size and can be held between two fingers, but in the micro-channels carved inside it, it’s hidden a three-dimensional and highly faithful model of a biliary tract cancer called cholangiocarcinoma, complete with its tumor microenvironment.

23 Jan 2024

New Virus Targets Dormant Bacteria, Boosting Antibiotic Power

In nature, the majority of bacteria adhere to a minimalistic lifestyle. When faced with nutrient scarcity or stress, they initiate a controlled shutdown of their metabolism, entering a resting state.

22 Jan 2024

New Technology Enables Minimally-Invasive, High-Resolution Recording of Brain Activity

Sensors built with a new manufacturing approach are capable of recording activity deep within the brain from large populations of individual neurons–with a resolution of as few as one or two neurons–in humans as well as a range of animal models, according to a study published in the Jan. 17, 2024 issue of the journal Nature Communications.

18 Jan 2024

Messenger RNA Therapy Could be Used to Correct Rare Liver Genetic Disease

By exploiting the technology used in Covid-19 vaccines, a team led by UCL, King's College London and Moderna scientists has created an effective therapy for a rare disease, in a study in mice, demonstrating the technology's potential therapeutic use in people.

16 Jan 2024

Genetic Analysis Unlocks Secrets of Previously Unknown Bacteria

Unknown germs are a common occurrence in hospitals. Researchers at the University of Basel have spent many years collecting and analyzing them.

12 Jan 2024

Preventing Immunological Rejection Following Transplantation

According to researchers, genetically modified stem cells may also open the door to novel regenerative medicine therapies for conditions including Type 1 diabetes.

12 Jan 2024