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Unveiling the Role of NCLX Protein in Mitochondrial Calcium Regulation and Autophagy

Unveiling the Role of NCLX Protein in Mitochondrial Calcium Regulation and Autophagy

An article published in The Faseb Journal describes a Brazilian study analyzing the correlation between two key energy metabolism regulation processes: the absorption and release of calcium ions by mitochondria, the organelles that generate energy for cells; and autophagy induced by calorie restriction.

3 May 2024

PI3K Enzyme's Dual Accelerator and Brake Mechanisms Uncovered

PI3K Enzyme's Dual Accelerator and Brake Mechanisms Uncovered

A group of researchers have expanded conventional knowledge on a critical enzyme that controls cell migration. In a recent publication in the journal Nature Communications, they reported that phosphoinositide 3-kinase (PI3K) not only acts as an accelerator to prompt cell motility, but it also has a built-in brake mechanism that impedes migration.

25 Apr 2024

Using State-of-the Art Imaging to Understand Lipid Dysfunction in Alzheimer's

Using State-of-the Art Imaging to Understand Lipid Dysfunction in Alzheimer's

Alzheimer's disease causes significant problems with memory, thinking and behavior and is the most common form of dementia, affecting more than 50 million people around the world each year.

24 Apr 2024

Study Uncovers Cells' Surprising Strategy to Control Signaling Pathways

Study Uncovers Cells' Surprising Strategy to Control Signaling Pathways

Healthy cells respond appropriately to changes in their environment. They do this by sensing what's happening outside and relaying a command to the precise biomolecule in the precise domain that can carry out the necessary response.

23 Apr 2024

Novel Imaging Technique Unveils Structural Details of Drug-Resistant Cancer Protein

Novel Imaging Technique Unveils Structural Details of Drug-Resistant Cancer Protein

Researchers have shown for the first time that a crucial interface in a protein that drives cancer growth could act as a target for more effective treatments.

20 Mar 2024

First Whole Genome Sequencing of Male Breast Cancer Reveals Potential Treatment Targets

First Whole Genome Sequencing of Male Breast Cancer Reveals Potential Treatment Targets

Male breast cancer has distinct alterations in the tumor genome that may suggest potential treatment targets, according to a study by Weill Cornell Medicine investigators.

5 Mar 2024

Telomerase's Double-Edged Sword: Preventing DNA Repair Mishaps

Telomerase's Double-Edged Sword: Preventing DNA Repair Mishaps

The natural ends of chromosomes appear alarmingly like broken DNA, much as a snapped spaghetti strand is difficult to distinguish from its intact counterparts.

16 Feb 2024

Identifying Phosphorylation Sites in Legume-Rhizobia Symbiosis

Identifying Phosphorylation Sites in Legume-Rhizobia Symbiosis

Legume plants are unique in that they can interact with rhizobia, which are soil-dwelling bacteria that fix nitrogen.

13 Feb 2024

Chemists Develop Two-Step Method to Create Promising Molecules for Life Sciences Research

Chemists Develop Two-Step Method to Create Promising Molecules for Life Sciences Research

Organic compounds in the field of chemistry range from simple hydrocarbons to complex molecules, with diverse functional groups added to the main carbon backbone.

30 Jan 2024

New Horizons in Chemical Biology: A Novel Approach to Synthesize Dibenzothiophene S-Oxides

New Horizons in Chemical Biology: A Novel Approach to Synthesize Dibenzothiophene S-Oxides

Dibenzothiophene S-oxides are important in various biochemical processes. However, their synthesis using conventional methods is not easy.

30 Jan 2024

Study Uncovers Chromatin Modifier-Centered Pathway for Grain Size Regulation in Rice

Study Uncovers Chromatin Modifier-Centered Pathway for Grain Size Regulation in Rice

Chromatin is the complex of DNA and proteins that makes up the genetic material in the nucleus of eukaryotic cells.

18 Jan 2024

Live-Cell Imaging Reveals How STING Activates Innate Immunity

Live-Cell Imaging Reveals How STING Activates Innate Immunity

When pathogens attack the body, the innate immune system goes to work protecting against the invading disease.

12 Jan 2024

Uncovering How Tomatoes Fight Off Notorious Blight

Uncovering How Tomatoes Fight Off Notorious Blight

Recently, The Plant Journal’s cover highlighted an innovative study that has garnered attention in the interesting field of plant biology.

10 Jan 2024

Mechanism of Pathogenic Fungus Aspergillus fumigatus Unveiled

Mechanism of Pathogenic Fungus Aspergillus fumigatus Unveiled

An international team of researchers, led by Professor Gustavo Goldman of the University of São Paulo and Maynooth University's Dr Özgür Bayram, has unveiled ground-breaking findings on Aspergillus fumigatus, which can cause deadly disease in humans.

5 Jan 2024

Hyperglycemia Impairs Mitochondrial Function and Survival of Human Adipose Tissue-Derived MSCs

Hyperglycemia Impairs Mitochondrial Function and Survival of Human Adipose Tissue-Derived MSCs

Mesenchymal stem cells (MSCs) are a type of stem cells that possess relevant regenerative abilities and can be used to treat many chronic diseases.

27 Dec 2023

Scientists Unravel the Mystery of Parkinson's Disease With 3D Protein Structures

Scientists Unravel the Mystery of Parkinson's Disease With 3D Protein Structures

Scientists at St. Jude Children's Research Hospital revealed the complex structure of two Parkinson's disease-related proteins, both of which are implicated in late-onset cases.

26 Dec 2023

NTNU Develops Dual-Mechanism Antibiotic Strategy to Combat Antimicrobial Resistance

NTNU Develops Dual-Mechanism Antibiotic Strategy to Combat Antimicrobial Resistance

NTNU has developed a promising antibiotic candidate against MRSA. Behind the discovery lies a methodology that may be important in the fight against antimicrobial resistance.

18 Dec 2023

Deep-Sea Vent Bacterium Sheds Light on Evolutionary Journey

Deep-Sea Vent Bacterium Sheds Light on Evolutionary Journey

A new bacterial species discovered at the deep-sea hydrothermal vent site 'Crab Spa' provides a deeper understanding of bacterial evolution.

1 Dec 2023

New Irreversible Inhibitor Overcomes Drug Resistance in Cancer Cells

New Irreversible Inhibitor Overcomes Drug Resistance in Cancer Cells

The concept of irreversible inhibitors binding permanently to a target protein has garnered growing interest for potential applications in drug development.

30 Nov 2023

Conserved Pathways and Evolutionary Transitions in Campylobacteria

Conserved Pathways and Evolutionary Transitions in Campylobacteria

Deep-sea hydrothermal vents function as underwater hot springs situated on the ocean floor. Within these vents, seawater infiltrates the ocean crust, undergoes heating, and ascends to the seafloor surface, carrying dissolved nutrients with it.

30 Nov 2023

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