Lewy Bodies News and Research

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Mapping Gene Signatures Unveils How Lewy Bodies Impact Brain Cells

A new study by scientists at Van Andel Institute provides an initial glimpse into the intricate molecular changes taking place in brain cells with Lewy bodies, crucial pathological markers of Parkinson’s disease and certain dementias.

17 Apr 2024

Exploring the Dual Role of Phosphorylated α-Synuclein in Healthy Neural Function

It has been found by researchers that phosphorylated α-synuclein, a protein linked to a number of neurodegenerative illnesses, including Parkinson's disease and Lewy body dementia, is also engaged in the regular processes of neuronal communication in a healthy brain.

10 Jan 2024

NEMO Protein Promotes Degradation of Harmful Alpha-Synuclein Aggregates in Parkinson's Disease

Researchers have identified a mechanism that promotes the breakdown of harmful protein deposits. If it malfunctions, it can lead to Parkinson’s disease.

21 Dec 2023

Study Uncovers a Protein-Protein Interaction Related to Parkinson's Disease

In a study published in Nature Communications, a team led by Krembil Brain Institute Senior Scientists, Drs. Lorraine Kalia and Suneil Kalia, and University of Toronto (U of T) Professor, Dr. Philip M. Kim, identified a protein-protein interaction that contributes to Parkinson's disease.

24 Apr 2023

New model, C. elegans, helps pursue research on Parkinson's disease

A tiny worm called the C. elegans is enabling scientists to explore the emerging theory that Parkinson's disease starts in the gut.

1 Mar 2023

Researchers reveal novel mechanism that links interferon activation and α-synuclein function in neurons

There are no disease-modifying therapies for Parkinson’s disease that can alter the course of the disease.

25 Jul 2022

Research points to a common thread linking diverse neurodegenerative diseases

Take a cell-deep tour of a brain afflicted with Alzheimer's disease, and you will find minuscule clumps of protein that seem suspicious. Ever since the 1980s, when neuroscientists began identifying these protein tangles, researchers have discovered that other brain diseases have their own tangled-protein signatures.

7 Mar 2022

New study uncovers potential driver of Parkinson’s disease

Parkinson's disease may be driven in part by cell stress-related biochemical events that disrupt a key cellular cleanup system, leading to the spread of harmful protein aggregates in the brain, according to a new study from scientists at Scripps Research.

24 Feb 2022

Neurons derived from human stem cells can predict the cardinal features of psychiatric illness

In a breakthrough that holds significant promise for early diagnosis and better treatment of psychiatric illness, researchers have for the first time used neurons derived from human stem cells to predict the cardinal features of a psychiatric illness, such as psychosis and cognitive deficits in patients with schizophrenia.

11 Jan 2022

Research reveals involvement of secretory granules in Parkinson’s disease

Recent research states that the number of secretory granules (SGs) in tyrosine hydroxylase-positive neurons and the marker proteins secretogranin III substantially lowered in the substantia nigra and striatum regions of mice exposed to 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine.

13 Oct 2021

Lewy Bodies News and Research

Mapping Gene Signatures Unveils How Lewy Bodies Impact Brain Cells

Exploring the Dual Role of Phosphorylated α-Synuclein in Healthy Neural Function

NEMO Protein Promotes Degradation of Harmful Alpha-Synuclein Aggregates in Parkinson's Disease

Study Uncovers a Protein-Protein Interaction Related to Parkinson's Disease

New model, C. elegans, helps pursue research on Parkinson's disease

Researchers reveal novel mechanism that links interferon activation and α-synuclein function in neurons

Research points to a common thread linking diverse neurodegenerative diseases

New study uncovers potential driver of Parkinson’s disease

Neurons derived from human stem cells can predict the cardinal features of psychiatric illness

Research reveals involvement of secretory granules in Parkinson’s disease

Study identifies the role of lysosomes in the spread of Parkinson’s disease

Scientists identify mystery protein that explains the origins of Parkinson's Disease

Study highlights the role of brain astrocyte cells in Parkinson's disease pathology

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