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Cellular Atlas of the Human Ovary Offers Hope for Restoring Hormone Production and Fertility

A new "atlas" of the human ovary provides insights that could lead to treatments restoring ovarian hormone production and the ability to have biologically related children, according to University of Michigan engineers.

9 Apr 2024

RNA Modification Offers Hope for Treating Neurological Diseases

The research team led by Yongchao C. Ma, Ph.D., at the Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago, uncovered a fundamental biological mechanism that holds promise for the development of novel treatments for neurological disorders like spinal muscular atrophy (SMA) and autism, as well as various types of cancer.

5 Apr 2024

Breakthrough Study Reveals Genetic Variants with Significant Impact on Obesity Risk

A study led by Medical Research Council (MRC) researchers has identified genetic variants in two genes that have some of the largest impacts on obesity risk discovered to date.

5 Apr 2024

Researchers Uncover the FACT-ETS-1 Antiviral Response Pathway

By focusing on a poxvirus protein, a team led by UT Southwestern Medical Center scientists has discovered an antiviral immune pathway that broadly fights a wide variety of viruses.

4 Apr 2024

Unveiling the Diversity and Evolutionary Dynamics of Centromeres Across Primates

A genomic study of human and selected nonhuman primate centromeres has revealed their unimaginable diversity and speed of evolutionary change.

4 Apr 2024

Study Reveals Structure of Two Nucleic Acid-Degrading Enzymes

When nucleic acids like DNA or RNA build up in a cell's cytoplasm, it sets off an alarm call for the immune system.

3 Apr 2024

TAM-Sense Offers Painless Imaging of Tumor Inflammation

The National Institutes of Health (NIH) has awarded two new grants totaling $6.7 million to researchers at the University of California San Diego School of Medicine.

2 Apr 2024

Unveiling the Potential of the New Antibiotics Against Bacteria

A novel family of antibiotics with strong action against bacteria resistant to many drugs has been found by Uppsala University researchers, and they have demonstrated that this class of antibiotics may treat bloodstream infections in mice.

2 Apr 2024

Rare YKT6 Gene Variants Linked to New Neurological Disorder

A recent collaborative study has discovered rare variants in the YKT6 gene as the cause of a new neurological disorder characterized by developmental delays along with severe progressive liver disease and a potential risk for liver cancer.

2 Apr 2024

Acidic Fortress of Tumors Could Rebuff Immune Cells

Cancer cells release a significantly more concentrated level of acid than previously known, forming an "acid wall" that could deter immune cells from attacking tumors, UT Southwestern Medical Center scientists show in a new study.

2 Apr 2024

Study may Provide a Roadmap for Addressing Cytokine Storms in Severe COVID-19

A recent USC study provides new information about why SARS-CoV-2, the virus behind the COVID-19 pandemic, may elicit mild symptoms at first but then, for a subset of patients, turn potentially fatal a week or so after infection.

1 Apr 2024

Scientists Create Lifelike Human Ear Replica with 3D Printing

Using state-of-the-art tissue engineering techniques and a 3D printer, researchers at Weill Cornell Medicine and Cornell Engineering have assembled a replica of an adult human ear that looks and feels natural.

1 Apr 2024

Structural and Biochemical Mechanism of ALDH6A1 Uncovered

ALDH6A1, a member of the ALDH family, plays a crucial role in the catabolic pathways of valine and thymine. Dysregulation of ALDH6A1 expression has been linked to a variety of diseases.

30 Mar 2024

UC San Diego Scientists Uncover Mechanism Behind Mitosis Timing

Each day, hundreds of billions of cells in our body cycle through a period of growth and division. Yet in that time, only about 30 minutes is spent on the critical orchestration of mitosis, when chromosomes are carefully segregated from one parent cell to the next generation of two daughter cells.

30 Mar 2024

Promising Compound Shows Potential in Reducing Alcohol Consumption

Scripps Research scientists have found that LY2444296-;a compound that selectively blocks the kappa opioid receptor (KOP)-;may reduce drinking in cases of alcohol dependence in animal studies.

30 Mar 2024

Cryo-EM Imaging Unveils Similar Protein Structures in Alzheimer's and Down Syndrome

More than 90% of people with Down syndrome, the most common chromosomal disorder in humans and the most frequent genetic cause of intellectual disability, are diagnosed with Alzheimer's disease by ages 55-60.

30 Mar 2024

Canadian-Led Study Identifies Genetic Links to Cerebral Palsy

A Canadian-led study has identified genes which may be partially responsible for the development of cerebral palsy.

29 Mar 2024

Penn Researchers Develop Breakthrough Technique for Creating Human Artificial Chromosomes

Human artificial chromosomes (HACs) capable of working within human cells could power advanced gene therapies, including those addressing some cancers, along with many laboratory applications, though serious technical obstacles have hindered their development.

28 Mar 2024

Nanoparticle-Based Therapy Shows Promise in Eradicating Tumors

A nanoparticle-based therapy developed by UT Southwestern Medical Center scientists stimulated an immune pathway that eradicated tumors in mouse models of various cancer types.

28 Mar 2024

Autofluorescence Reveals Clues to Stem Cell Dormancy

With the help of a tool created at the University of Wisconsin–Madison, researchers can better study the various states of stem cells in the nervous system by utilizing the light naturally emitted by biological specimens.

28 Mar 2024