Neurodegenerative Diseases News and Research

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Novel Method can Measure the Abundance and Modification of tRNA Molecules in a Single Step

Ribonucleic acid (RNA) molecules are present in all living cells, with different types of RNA having different jobs.

7 Apr 2023

Cold Temperature Increases Human Life Expectancy

Cold activates a cellular cleansing mechanism that breaks down harmful protein aggregations responsible for various diseases associated with aging.

4 Apr 2023

Determining the structure of protein pumps using cryo-EM

A rare, genetic disorder known as Hailey-Hailey disease causes patches of blisters to develop mainly in the folds of skin under the breasts, in the groin, and the armpits.

29 Mar 2023

Eye color genes play important roles in maintaining retinal health

Metabolic pathways consist of a series of biochemical reactions in cells that convert a starting component into other products.

24 Mar 2023

Brain scans link signs of cellular aging to symptoms of Alzheimer’s

According to a new study led by Anya Topiwala of Oxford Population Health, a division of the University of Oxford in the United Kingdom, and published on March 22nd, 2023 in the open-access journal PLOS ONE, changes in the brain caused by Alzheimer’s disease are connected to telomeres shortening, the protective caps on the ends of chromosomes that shorten as cells age.

23 Mar 2023

DNA drugs help restore the normal processing of protein-encoding RNA

A protein named TDP-43 has been lost from its normal location in the nucleus of the cell in virtually all persons having amyotrophic lateral sclerosis (ALS) and in up to half of all cases of frontotemporal dementia and Alzheimer’s disease (AD).

From UC San Diego 20 Mar 2023

High doses of sucralose limit T cell proliferation and differentiation

Scientists at the Francis Crick Institute have found that high consumption of a common artificial sweetener, sucralose, lowers activation of T-cells, an important component of the immune system, in mice.

16 Mar 2023

Researchers find methods to awaken and revive neural stem cells

Some areas of the adult brain contain quiescent, or dormant, neural stem cells that can potentially be reactivated to form new neurons. However, the transition from quiescence to proliferation is still poorly understood. A team led by scientists from the Universities of Geneva (UNIGE) and Lausanne (UNIL) has discovered the importance of cell metabolism in this process and identified how to wake up these neural stem cells and reactivate them. Biologists succeeded in increasing the number of new neurons in the brain of adult and even elderly mice. These results, promising for the treatment of neurodegenerative diseases, are to be discovered in the journal Science Advances.

2 Mar 2023

RNA modification plays a vital role in TDP-43-related neurodegeneration in ALS

Nearly 100% of cases of amyotrophic lateral sclerosis-the progressive, fatal neurodegenerative disease known as ALS or Lou Gherig's disease-involve the buildup of a protein called TDP-43.

28 Feb 2023

Artificial BBB model can help determine how well antibody-based therapies can enter the brain

A research group at Uppsala University has developed a simple and effective artificial blood-brain barrier model that can be used to determine how well antibody-based therapies can enter the brain.

27 Feb 2023

Scientists discover two ways to preserve diseased upper motor neurons in ALS

Northwestern Medicine scientists have discovered two ways to preserve diseased upper motor neurons that would normally be destroyed in ALS, based on a study in mice. Upper motor neurons initiate movement, and they degenerate in ALS.

24 Feb 2023

Scientists unravel the secrets of polydopamine coatings

Dopamine is best known as a neurotransmitter. What is rather unknown, however, the underwater glue used by mussels contains large amounts of L-Dopa molecules, an analog of dopamine.

17 Feb 2023

New method for studying mitochondria using advanced imaging technology

Scientists at Scripps Research have developed an advanced imaging-based approach that provides a unique perspective on mitochondria, which are best known as the “powerhouses” of cells.

17 Feb 2023

DZNE scientists discover major role of centrosome in neuronal migration

Researchers from the DZNE have solved an important puzzle in neurobiology: the wiring and the movement of nerve cells are interwoven, but separately controlled.

16 Feb 2023

Inventia Life Science collaborates with MSD to develop 3D advanced cell models for neurodegenerative disease drug discovery

Inventia Life Science, a world leader in advanced cell models for biomedical research and drug discovery, today announced a collaboration with MSD (tradename of Merck & Co., Inc., Rahway, N.J., USA) using Inventia’s RASTRUM™ 3D cell culture platform.

From Inventia Life Science 16 Feb 2023

New approach to better target cellular proteins

By studying how enzymes move from one membrane compartment to another inside a cell, scientists at the University of Illinois Chicago have figured out a way to better target cellular proteins, which play a role in many diseases.

16 Feb 2023

New center at UCLA focuses on the microbiome’s role in disease prevention

Among the most promising areas of scientific inquiry is the study of the human microbiome and its effect on health. To fuel more rapid progress in this field, Andrea and Donald Goodman and Renee and Meyer Luskin have made a $20 million gift to establish the UCLA Goodman–Luskin Microbiome Center.

16 Feb 2023