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Unlocking Glucose-Driven Mechanisms of Immunosuppression in Glioblastoma

The Wistar Institute assistant professor Filippo Veglia, Ph.D., and team, have discovered a key mechanism of how glioblastoma -; a serious and often fatal brain cancer -; suppresses the immune system so that the tumor can grow unimpeded by the body's defenses.

6 May 2024

Targeting RNA Modifications: A Novel Approach for Neuroblastoma Treatment

Neuroblastoma is a common pediatric cancer that originates in developing nerve cells outside the brain.

6 May 2024

Protein Complex Movement May Regulate Cell Division, Impacting Disease Research

Scientists at Umeå University in Sweden have found that the movement of a unique protein complex known as the Mediator along DNA genes may affect the process of cell division.

6 May 2024

Study Demonstrates How the Warburg Effect is Crucially Linked to Cancer Progression

Researchers have revealed crucial insights into how the Warburg effect causes the dedifferentiation of cancer cells through epigenetic reprogramming.

3 May 2024

UNC Researchers Create Key Tool for Kaposi Sarcoma Drug Development

Researchers at UNC Lineberger Comprehensive Cancer Center, after decades of research efforts, have developed a mouse model of Kaposi sarcoma that could be key to the development of new drugs to treat the disease.

30 Apr 2024

Epigenetics May Spark Tumors Without DNA Mutations

Scientists from the CNRS are part of a research team that has found that epigenetic changes, or modifications that affect the regulation of gene expression, can be the sole cause of cancer, one of the world's leading causes of death.

25 Apr 2024

Study Unravels How Tumors Evade Immune Response by Targeting T Cells

Tumors actively prevent the formation of immune responses by so-called cytotoxic T cells, which are essential in combating cancer.

25 Apr 2024

Localized Delivery Minimizes Side Effects of Immunotherapy

Cancer is the monster of the society.. The American Cancer Society reports that over 600,000 Americans lost their lives to cancer in the previous year. Medical progress has been shaped by the unwavering quest to understand this complex disease, leading to the development of less invasive yet highly effective treatment procedures.

22 Apr 2024

New Delivery System Opens the Door to Gene-Silencing Therapy

The next generation of medications, known as antisense oligonucleotides (ASOs), works by preventing the transmission of damaging genetic messages.

16 Apr 2024

Cataloging Bacteria in Cancer Metastases

Researchers at the Netherlands Cancer Institute have compiled a detailed catalog of bacteria living in cancer metastases.

10 Apr 2024

Understanding Prostate Cancer Disparities Through Proteogenomics

Certain proteogenomic signatures in the prostate cancers of men of African and European ancestries were associated with higher risk of metastasis and/or recurrence of the disease, according to a study presented at the American Association for Cancer Research (AACR) Annual Meeting 2024, held April 5-10.

10 Apr 2024

Precision Combination Therapy Better Controls High-Risk Subtypes of B-ALL in Mouse Models

Despite having an overall survival rate of 94%, B-cell acute lymphoblastic leukemia (B-ALL), the most common childhood cancer, can prove challenging to treat, with survival among relapsed or resistant cases falling between 30-50%.

9 Apr 2024

Engineering Live Vaccines for Improved Immune Response

Bacterial proteins frequently outsmart the immune system, making it more challenging to fight off the bacteria that cause illnesses like staph infections.

5 Apr 2024

Gut Microbiota Signatures Linked to KRAS Mutations in Colorectal Cancer Patients

For about 40% of people diagnosed with colorectal cancer (CRC), the tumor carries a mutation in a gene called KRAS. Many of those mutations have been linked to shorter survival and more aggressive forms of disease.

5 Apr 2024

TAM-Sense Offers Painless Imaging of Tumor Inflammation

The National Institutes of Health (NIH) has awarded two new grants totaling $6.7 million to researchers at the University of California San Diego School of Medicine.

2 Apr 2024

Acidic Fortress of Tumors Could Rebuff Immune Cells

Cancer cells release a significantly more concentrated level of acid than previously known, forming an "acid wall" that could deter immune cells from attacking tumors, UT Southwestern Medical Center scientists show in a new study.

2 Apr 2024

UC San Diego Scientists Uncover Mechanism Behind Mitosis Timing

Each day, hundreds of billions of cells in our body cycle through a period of growth and division. Yet in that time, only about 30 minutes is spent on the critical orchestration of mitosis, when chromosomes are carefully segregated from one parent cell to the next generation of two daughter cells.

30 Mar 2024