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Mount Sinai researchers illuminate the role of DNA methylation in Alzheimer's disease

Mount Sinai researchers have published a study in Alzheimer's & Dementia: The Journal of the Alzheimer's Association that sheds new light on the role of DNA methylation in Alzheimer's disease (AD).

23 Feb 2023

Research reveals gene expression changes in two brain regions of individuals with cocaine use disorder

Individuals with cocaine use disorder exhibit gene expression changes in two brain regions: the nucleus accumbens, a region associated with reward, and the caudate nucleus, a region mediating habit formation, according to research conducted at the Icahn School of Medicine at Mount Sinai and published February 10 in Science Advances.

13 Feb 2023

Persistent tumor mutation load may help predict outcome of novel immunotherapies

Cancer experts have tried, sometimes unsuccessfully, to use the total number of mutations in a tumor, called the tumor mutation burden (TMB), to predict a patient's response to immunotherapy.

27 Jan 2023

Researchers propose a solution to delayed molecular diagnosis and therapy in childhood genetic diseases

Rady Children’s Institute for Genomic Medicine (RCIGM®) recently announced the publication in Nature Communications of research that describes and examines the efficiency of Genome-to-Treatment (GTRxTM), a computer-controlled, virtual disease management system that combines a quick Whole Genome Sequencing (rWGS®) diagnosis accomplished in 13.5 hours with a custom lab management information system and analysis pipeline.

28 Jul 2022

New technique enables researchers to pinpoint protein–drug interaction

The discovery and development of new drugs may be facilitated by the use of a novel method that can analyze the interactions of drug molecules with proteins in tissue samples. In cooperation with the major biopharmaceutical company AstraZeneca, University of Birmingham researchers created the method.

15 Jul 2022

Researchers work on DNA-delivered antibodies to stop COVID-19

A new COVID-19 antibody delivery approach has progressed to clinical trials, thanks to funding from the Defense Advanced Research Projects Agency (DARPA) and the Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense (JPEO-CBRND).

11 Jul 2022

Challenges in Drug Discovery; Where are we now, and where are we going?

As part of our SLAS Europe 2022 coverage, we speak to Steve Rees, Vice-President of Discovery Biology at AstraZeneca, about the challenges currently faced by the drug discovery sector.

From Society for Laboratory Automation and Screening (SLAS) 8 Jul 2022

New reports highlight the resilience of local food sector during the Covid-19 pandemic

Local food suppliers saved the day during the Covid-19 pandemic food shortages, but new research from the University of Sheffield also finds lessons need to be learned if national food systems are to survive future crises.

9 May 2022

Radioconjugate drugs could change the future of cancer treatment

Many current cancer treatments make patients very sick because even the most targeted treatments kill healthy cells as well as cancer cells. But a new type of treatment called a radioconjugate is getting the attention of oncologists.

21 Apr 2022

Experimental "gene silencing" therapy reduces a important driver of heart disease risk by up to 98%

Findings from a new Cleveland Clinic-led phase 1 trial show that an experimental "gene silencing" therapy reduced blood levels of lipoprotein(a), a key driver of heart disease risk, by up to 98%.

4 Apr 2022

New vaccine providing protection against future animal-to-human viral diseases may be possible

A future vaccine providing protection against a wide range of coronaviruses that jump from their original animal hosts to humans -; including SARS-CoV-2, the cause of COVID-19 -; may be possible, say Johns Hopkins Medicine researchers, based on findings from their recent study.

17 Feb 2022

Risk linked to coronary arteriosclerosis may be explained by changes in gene networks

Up to 60 percent of the risk associated with coronary arteriosclerosis may be explained by changes in the activity of hundreds of genes working together in networks across several organs in the body.

17 Jan 2022

Changes in the activity of gene networks may explain arteriosclerosis risk

Up to 60 percent of the risk associated with coronary arteriosclerosis may be explained by changes in the activity of hundreds of genes working together in networks across several organs in the body.

13 Jan 2022

Omicron variant hampers the effectiveness of vaccines and monoclonal antibodies, study shows

The Omicron variant was detected for the first time in South Africa in November 2021 and has since spread to many countries.

From Institut Pasteur 10 Jan 2022

Single-cell spatial analysis may provide information about neoadjuvant therapy for triple-negative breast cancer

A next-generation technology that allows the study of protein expression at the single-cell level and the location of the cells within the tumor microenvironment (TME) was feasible and provided information on the benefit of adding the immune checkpoint inhibitor atezolizumab (Tecentriq) to chemotherapy as neoadjuvant treatment for patients with early high-risk and locally advanced triple negative breast cancer (TNBC), according to results presented at the San Antonio Breast Cancer Symposium, held December 7-10, 2021.

8 Dec 2021

Targeted drug shows promise against brain metastases from kidney cancer

A targeted drug has shown promising activity against brain metastases resulting from kidney cancer, achieving a 50 percent response rate, and supporting further studies of the drug in this patient group whose poor prognosis has created a significant unmet need.

22 Oct 2021

AstraZeneca News and Research

Mount Sinai researchers illuminate the role of DNA methylation in Alzheimer's disease

Research reveals gene expression changes in two brain regions of individuals with cocaine use disorder

Persistent tumor mutation load may help predict outcome of novel immunotherapies

Researchers propose a solution to delayed molecular diagnosis and therapy in childhood genetic diseases

New technique enables researchers to pinpoint protein–drug interaction

Researchers work on DNA-delivered antibodies to stop COVID-19

Challenges in Drug Discovery; Where are we now, and where are we going?

New reports highlight the resilience of local food sector during the Covid-19 pandemic

Radioconjugate drugs could change the future of cancer treatment

Experimental "gene silencing" therapy reduces a important driver of heart disease risk by up to 98%

New vaccine providing protection against future animal-to-human viral diseases may be possible

Risk linked to coronary arteriosclerosis may be explained by changes in gene networks

Changes in the activity of gene networks may explain arteriosclerosis risk

Omicron variant hampers the effectiveness of vaccines and monoclonal antibodies, study shows

Single-cell spatial analysis may provide information about neoadjuvant therapy for triple-negative breast cancer

Targeted drug shows promise against brain metastases from kidney cancer

Study explains why shift workers are vulnerable to heart problems

Study details replication and immune evasion of Delta SARS-CoV-2 variant

Study confirms long-term immune system responses of adenovirus vaccines for COVID-19

Scientists discover genes responsible for smoking-related decline in lung function

Quorum Bio: Where Synthetic Biology Meets Sustainable Farming

Diagnostic Biochips: Pioneering Brain Research Tools for the Future

Commercializing Innovation in a Life Sciences Ecosystem

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