Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

Individuals infected with mild-to-moderate COVID 19 mount a robust antibody response

The vast majority of individuals infected with mild-to-moderate COVID 19 mount a robust antibody response that is relatively stable for at least five months, according to research conducted at the Icahn School of Medicine at Mount Sinai and published October 28, in the journal Science.

29 Oct 2020

New method for producing FTVI enzyme could enhance therapeutic potential of cord blood transplants

A new way of producing an enzyme called fucosyltransferase VI (FTVI) in the lab could help enhance the therapeutic potential of cord blood transplants.

23 Oct 2020

Researchers demonstrate the impact of epithelial cells, mammary microenvironment on breast cancer cells

The cover for issue 30 of Oncotarget features Figure 4, "RNAseq results demonstrating differences between normal, cancer, and redirected cells," by Frank-Kamenetskii, et al. which reported that the influence of breast cancer cells on normal cells of the microenvironment, such as fibroblasts and macrophages, has been heavily studied but the influence of normal epithelial cells on breast cancer cells has not.

19 Oct 2020

Immunotherapy using CAR NKT cells shows promise for treating solid tumors

Natural killer T (NKT) cells, a type of immune cells known for their potent anti-cancer properties in murine tumor models, have been developed into a novel form of immunotherapy to treat patients with cancer.

14 Oct 2020

Bone destruction caused by too little sugar

Bone marrow cancer is currently an incurable disease that affects about 400 people in Norway every year. Professor Therese Standal at NTNU has now found an important reason for bone destruction in people with this disease.

12 Oct 2020

Reducing the harvest period of stem cell sheets to two days

Stem cells are cell factories that constantly divide themselves to create new cells. Implanting stem cells in damaged organs can regenerate new tissues.

9 Oct 2020

Immune cell biomarker may help identify patients at risk for graft-versus-host disease

A recent report published in Science Translational Medicine by MUSC Hollings Cancer Center investigator Sophie Paczesny, M.D., Ph.D., sheds light on immune cell biomarkers that may reveal which patients are most at risk for graft-versus-host disease (GVHD), a life-threatening condition that can arise after hematopoietic stem cell transplantation (HSCT) for treatment of liquid cancers such as leukemia.

8 Oct 2020

New drug shows promise in the treatment of neuroblastoma

A drug has shown great promise in the treatment of neuroblastoma, an aggressive form of childhood cancer. The study was led by researchers at Lund University in Sweden, and is published in the journal Science Translational Medicine.

7 Oct 2020

MIT engineers develop a method to turn off specific genes in bone marrow cells

Using specialized nanoparticles, MIT engineers have developed a way to turn off specific genes in cells of the bone marrow, which play an important role in producing blood cells.

From Massachusetts Institute of Technology (MIT) 6 Oct 2020

Researchers identify new way to treat chronic myelogenous leukemia

Scientists have detected a second path to treat chronic myelogenous leukemia, which is known to affect older adults, despite its resistance to drugs.

22 Sep 2020

Combining stem cell therapy with educational intervention can help children with autism

Results of a clinical trial released today in STEM CELLS Translational Medicine indicate that a combination of stem cell therapy and educational intervention can significantly help children with autism spectrum disorder (ASD).

10 Sep 2020

Greater gut microbial diversity in kidney cancer patients linked to better treatment outcomes

Physicians at City of Hope, working in collaboration with scientists at Translational Genomics Research Institute (TGen), have found that greater gut microbial diversity in patients with metastatic kidney cancer is associated with better treatment outcomes on Food and Drug Administration-approved immunotherapy regimens.

20 Aug 2020

LJI scientists tracked down rare stem cells that generate neutrophils in humans

Neutrophils are the warriors of the immune system. They are always ready to spring to action to help heal injuries or fight off disease. Unless, that is, something goes wrong in their developmental process.

19 Aug 2020

RNA-based therapeutic approach could be used to cure hereditary diseases

Short RNA molecules can be used as medication. Their effectiveness is based on the genetic information they carry: therapeutic RNA can bind to the body's own RNA and thus influence how it functions.

19 Aug 2020

Novel gene editing approach removes latent herpes simplex virus 1

Infectious disease researchers at Fred Hutchinson Cancer Research Center have used a gene editing approach to remove latent herpes simplex virus 1, or HSV-1, also known as oral herpes.

19 Aug 2020

Study reveals why immunity boost from seasonal flu vaccines is not long lasting

A study from Emory Vaccine Center provides insights into why the boost in immunity from seasonal flu vaccination lasts for months but not years, unlike some childhood vaccinations.

14 Aug 2020

A genetic link discovered to predict treatment response for patients with rare, aggressive cancer

A Singapore team led by clinician-scientists and researchers from the National Cancer Centre Singapore (NCCS) discovered a genetic link to better predict treatment response for relapsed/refractory patients with natural- killer T-cell lymphoma (NKTCL), a highly aggressive form of blood cancer.

13 Aug 2020

Epigenetics key to daily production of 10 billion blood cells without mistakes

Just one in 2,000 bone marrow cells are hematopoietic stem cells (HSC), but these are the source of the ten billion blood cells humans make every day.

6 Aug 2020

Deep Learning On Cell Signaling Networks Establishes AI For Single-Cell Biology

Computer systems that emulate key aspects of human problem solving are commonly referred to as AI. This field has seen massive progress over the last years.

6 Aug 2020

Clinical trial shows CAR-T cell therapy can be used for treating Hodgkin lymphoma

CAR-T cell therapy, which attacks cancer cells using a person's reprogrammed immune cells, has been used to treat Hodgkin lymphoma with remarkable success for the first time, according to the results of an early phase clinical trial led by researchers at UNC Lineberger Comprehensive Cancer Center and Baylor College of Medicine in Houston.

24 Jul 2020

Bone Marrow News and Research

Individuals infected with mild-to-moderate COVID 19 mount a robust antibody response

New method for producing FTVI enzyme could enhance therapeutic potential of cord blood transplants

Researchers demonstrate the impact of epithelial cells, mammary microenvironment on breast cancer cells

Immunotherapy using CAR NKT cells shows promise for treating solid tumors

Bone destruction caused by too little sugar

Reducing the harvest period of stem cell sheets to two days

Immune cell biomarker may help identify patients at risk for graft-versus-host disease

New drug shows promise in the treatment of neuroblastoma

MIT engineers develop a method to turn off specific genes in bone marrow cells

Researchers identify new way to treat chronic myelogenous leukemia

Combining stem cell therapy with educational intervention can help children with autism

Greater gut microbial diversity in kidney cancer patients linked to better treatment outcomes

LJI scientists tracked down rare stem cells that generate neutrophils in humans

RNA-based therapeutic approach could be used to cure hereditary diseases

Novel gene editing approach removes latent herpes simplex virus 1

Study reveals why immunity boost from seasonal flu vaccines is not long lasting

A genetic link discovered to predict treatment response for patients with rare, aggressive cancer

Epigenetics key to daily production of 10 billion blood cells without mistakes

Deep Learning On Cell Signaling Networks Establishes AI For Single-Cell Biology

Clinical trial shows CAR-T cell therapy can be used for treating Hodgkin lymphoma

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