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Three proteins as potential new therapeutic targets in movement disorders

Three members of a family of proteins have been identified that are important to helping us fine tune the activity of brain chemicals which enable us to walk or stand at will, scientists report.

11 Feb 2022

A simple route for synthesizing fungal compound and its derivatives

The solutions to many of humanity's problems can be found within nature. For instance, who could have guessed that an antibiotic as powerful as penicillin would be found in a common mold, or that the drug aspirin would be derived from the bark of the willow tree?

From Tokyo University of Science 10 Feb 2022

Novel method can report specific immune cell types using only DNA from blood

Flow cytometry is a powerful and complex technology used to count, sort or measure characteristics of cells and to detect biomarkers.

10 Feb 2022

Study compares the chromosomal position of genes from diverse animals

Many of today's marine invertebrates, including sponges and jellyfish, have chromosomes with the same ancient structure they inherited from their primitive ancestors more than 600 million years ago, according to a new study.

9 Feb 2022

Identification of a bivalent histone-mark switch essential for angiogenesis

Defying conventional epigenomic wisdom, the non-conventional polycomb (PRC)1 variant paradoxically overwhelms the conventional PRC-mediated gene silencing in activated endothelial cells.

9 Feb 2022

Cell culture environments are unstable and drive reproducibility crisis

Culture environments of different cell types growing in culture vessels or Petri dishes vary significantly from each other and from conditions in the living body, potentially driving the "reproducibility crisis" in biomedical research, according to a team of KAUST bioscientists.

9 Feb 2022

Gene-editing techniques could be used to tackle mitochondrial disorders, study shows

Defective mitochondria – the 'batteries' that power the cells of our bodies – could in future be repaired using gene-editing techniques.

9 Feb 2022

MALS Detector for GPC/SEC characterization of polymers & proteins

The BI-MwA Multi-Angle Light Scattering (MALS) system from Testa Analytical Solutions e.K. is a high-performance detector for studying polymers and proteins in solution as well as investigating aggregation, oligomerization, and complex formation.

From TESTA Analytical Solutions 9 Feb 2022

Tropical sea anemone stings could hold key to new pain-relieving drugs

QUT PhD researcher Lauren Ashwood has studied sea anemones' venom makeup extensively, in particular, Telmatactis stephensoni a reef-based sea anemone that can grow from 8 to 10 cm.

8 Feb 2022

Kras oncogenes use genetic reprogramming to drive tumorigenesis

Cancerous tumors are made up of rapidly growing, abnormally shaped, cells that can infiltrate and destroy healthy tissues, travel to other parts of the body, and form additional tumors.

8 Feb 2022

Epigenetic inheritance enhances mating in stressed out C. elegans

Sexual reproduction allows organisms to mix up their genes and develop new adaptations to survive a harsh and ever-changing environment.

8 Feb 2022

Groundbreaking discovery could lead to the design of novel therapeutics for wound-healing

An international team led by the Case Western Reserve University School of Medicine has discovered novel properties of the protein Gasdermin B that promotes repair of cells lining the gastrointestinal tract in people with chronic inflammatory disorders like Crohn's disease and ulcerative colitis.

8 Feb 2022

In vivo tracking of unlabeled stem cells using sugars

A Johns Hopkins Medicine scientist who spent 30 years figuring out how to put chemical labels into cells to track their movement in living tissues has found that certain self-renewing stem cells have built-in tracers -; made out of sugars -; that can do the job without added chemical "labels" when injected into mouse brains.

8 Feb 2022

TAB1 gene plays a key role in maintaining stem cells during ovule formation in rice plants

Rice has long been a staple food for more than half the global population. The United Nations even declared 2004 the International Year of Rice to raise awareness and encourage action to protect and advance the crop for a rapidly growing population.

7 Feb 2022

Scientists design an open microfluidic system for excellent recovery of purified DNA

In the war against cancer, the first step towards treating them is an accurate diagnosis of the problem. A technique that helps plan a better course of treatment is a biopsy.

7 Feb 2022

New gene therapy approach may help treat a wide variety of electrical heart diseases

Biomedical engineers at Duke University have demonstrated a gene therapy that helps heart muscle cells electrically activate in live mice.

7 Feb 2022

Study reveals how the body controls inflammation during removal of damaged cells

A research team from Cologne and Osnabrück has investigated in detail how messenger substances signal inflammation during the removal of damaged cells in the body.

7 Feb 2022

Scientists use CRISPRa to discover genes that play a role in immune cell biology

CRISPR genome editing has served as a powerful tool for deleting or altering DNA sequences and studying the resulting effect.

4 Feb 2022

Researchers gain detailed insight into the mechanism of a light-driven chloride pump

Many bacteria and unicellular algae have light-driven pumps in their cell membranes: proteins that change shape when exposed to photons such that they can transport charged atoms in or out of the cell.

4 Feb 2022

New method helps distinguish bacterial DNA from human and other non-bacterial cells

For decades, a small group of cutting-edge medical researchers have been studying a biochemical, DNA tagging system, which switches genes on or off. Many have studied it in bacteria and now some have seen signs of it in, plants, flies, and even human brain tumors.

4 Feb 2022

Cell News and Research

Three proteins as potential new therapeutic targets in movement disorders

A simple route for synthesizing fungal compound and its derivatives

Novel method can report specific immune cell types using only DNA from blood

Study compares the chromosomal position of genes from diverse animals

Identification of a bivalent histone-mark switch essential for angiogenesis

Cell culture environments are unstable and drive reproducibility crisis

Gene-editing techniques could be used to tackle mitochondrial disorders, study shows

MALS Detector for GPC/SEC characterization of polymers & proteins

Tropical sea anemone stings could hold key to new pain-relieving drugs

Kras oncogenes use genetic reprogramming to drive tumorigenesis

Epigenetic inheritance enhances mating in stressed out C. elegans

Groundbreaking discovery could lead to the design of novel therapeutics for wound-healing

In vivo tracking of unlabeled stem cells using sugars

TAB1 gene plays a key role in maintaining stem cells during ovule formation in rice plants

Scientists design an open microfluidic system for excellent recovery of purified DNA

New gene therapy approach may help treat a wide variety of electrical heart diseases

Study reveals how the body controls inflammation during removal of damaged cells

Scientists use CRISPRa to discover genes that play a role in immune cell biology

Researchers gain detailed insight into the mechanism of a light-driven chloride pump

New method helps distinguish bacterial DNA from human and other non-bacterial cells

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