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Role of p53-mediated metabolism in preventing genomic instability

The gene that codes for the protein p53 is most likely the most significant factor in defending human cells against DNA-damaging agents that cause cancer. The protein permits cells to repair DNA damage and so prevents the formation of malignancies, earning it the nickname “guardian of the genome.”

4 Nov 2022

“Screen-first” approach mines microbes directly from the environment

The best method now available for researchers to isolate a specific microorganism with a given metabolic function from an environment is to collect a sample of cells, culture them, and then test them for the desired cell functions.

4 Nov 2022

New bioprinting platform to replicate tumors in 3D spheroids

Bowel cancer patients could in future benefit from a new 3D bioprinting technology which would use their own cells to replicate the complex cellular environment of solid tumors in 3D models.

3 Nov 2022

Discovery may help alleviate the increasing global problem of high soil salinity on farmland

To avoid salt in soil, plants can change their root direction and grow away from saline areas. University of Copenhagen researchers helped find out what makes this possible.

3 Nov 2022

RNA-edited regions in brain shed light on neurodevelopment and disease

Numerous sites in the brain where RNA is altered over the course of a person’s lifespan through a process known as adenosine-to-inosine (A-to-I) editing have been identified by Mount Sinai researchers.

3 Nov 2022

AI-based holographic microscope monitors microplanktons at the individual level

For the first time, scientists can now watch the lives of microplankton at the individual level utilizing holograms produced in digital microscopes and processed by artificial intelligence (AI).

3 Nov 2022

New method reveals how photosynthetic microalgae interact with their environment

Microalgae are algae too small to see with the human eye that live in both fresh and sea water. They are responsible for half of fixation of carbon that occurs on Earth through photosynthesis.

2 Nov 2022

Novel liposomal nanovaccines strongly activate cellular immunity

Cancer immunotherapies, such as immune checkpoint inhibition therapy, have been attracting attention in recent years as new methods for treating cancer.

2 Nov 2022

New technique could help fine-tune the production of useful proteins

Using an approach based on CRISPR proteins, MIT researchers have developed a new way to precisely control the amount of a particular protein that is produced in mammalian cells.

2 Nov 2022

Quantifying microanatomical tissue structures without human intervention

Scientists at Weill Cornell Medicine have created a computational method for mapping the architecture of human tissues in extraordinary detail. Their method guarantees to expedite research on organ-scale cellular interactions and could lead to strong new diagnostic strategies for a variety of disorders.

1 Nov 2022

New approach to clear early stage pre-cancerous tumor cells

A novel method of reprogramming the immune cells to shrink or destroy cancer cells has been demonstrated to work in melanoma, a difficult to treat and destructive skin cancer.

1 Nov 2022

Genetic timestamping tracks the fate of plasma cells over time

Vaccines function by effectively producing immune cells that live for a long time, frequently for decades. These immune cells form a protective barrier that prevents or reduces re-infection, as well as a memory that enables one to identify an old invader, such as a virus, and eliminate it before it causes disease.

1 Nov 2022

Potential therapeutic strategy for medulloblastoma relapse

Medulloblastoma, a kind of malignant brain tumor, can develop resistance to therapy, resulting in relapse. Uppsala University scientists found a protein that causes tumor cells to rest and become insensitive to radiation treatment.

1 Nov 2022

New tool advances potential means to deliver gene therapy

Researchers from Johns Hopkins Medicine claim to have successfully “slid” genetic instructions into a cell and produced essential proteins that were lacking from those cells using a cell’s normal process for creating proteins.

1 Nov 2022

Identifying the structure of the SEA complex

The mTOR protein is important for cell growth, proliferation, and survival. Its activity fluctuates according to nutrient availability and growth factors like hormones.

1 Nov 2022

Metabolite from pomegranate to boost immune cells that fight tumors

Researchers from the Georg-Speyer-Haus in Frankfurt am Main, Germany, and Goethe University Frankfurt have succeeded in developing a new strategy for the treatment of colorectal cancer as part of an interdisciplinary initiative of the LOEWE Center Frankfurt Cancer Institute (FCI).

28 Oct 2022

Plant root reprogramming via synthetic genetic circuits

An essential stage in genetically modifying plants to create better bioenergy crops is gene activity control. The results of this research led to the creation of artificial genes that could be coupled to produce certain patterns of gene expression in plants.

28 Oct 2022

Immunological mechanisms behind the development of alloantibodies

Hemophilia A is the most frequent severe variant of hemophilia. It nearly mostly affects men. The condition is frequently treatable, although not for all patients. A study at the University of Bonn has now highlighted a critical mechanism required for the therapy to be efficient.

28 Oct 2022

Gene governing cell division could shield against Alzheimer’s

According to a recent study by researchers at the University of Colorado Anschutz Medical Campus, the overexpression of a gene linked to cell division and the structure and function of neurons could prevent and protect against cognitive deterioration in both mice and people with Alzheimer’s disease (AD).

28 Oct 2022

Novel method tags proteins from specific cancer cells

Biomarkers are extremely useful tools that enable doctors to research biology and disease by, for instance, diagnosing a disease from a blood or tissue sample, predicting whether a treatment will be beneficial in a person, or determining how much of a drug is entering diseased cells.

28 Oct 2022