Cell Death News and Research

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New drug target identified for antibiotic-resistant bacteria

Scientists have discovered a key mechanism that enables dangerous bacteria to develop resistance to antibiotics.

9 Mar 2021

Targeted immunotherapy could improve radiotherapy response in cancer cells

Cancers that are resistant to radiotherapy could be rendered susceptible through treatment with immunotherapy, a new study suggests.

9 Mar 2021

Interbacterial toxins may contribute to bacterial genetic diversity

A toxin produced by bacteria as a defense mechanism causes mutations in target bacteria that could help them survive, according to a study published today in eLife.

24 Feb 2021

Gut microbiome alterations help melanoma patients to respond to immunotherapy

Statistical modeling developed by Oregon State University researchers has confirmed that changes to melanoma patients' gut microbiome led them to respond to a type of treatment capable of providing long-term benefit.

17 Feb 2021

Antioxidant in green tea may lead to new anti-cancer drugs

Green tea contains an antioxidant that may boost the concentrations of p53, called the “guardian of the genome,” for its potential to kill cancerous cells.

15 Feb 2021

Animal model yields important insights into T cell exhaustion

T lymphocytes, or T cells, are an important component of our immune system. They can recognize foreign proteins, so-called antigens, as peptide fragments - for instance, those derived from viruses or cancer cells.

15 Feb 2021

Natural compounds in apples and other fruits may improve brain function

According to a new study, apples and other fruits contain natural substances that may help trigger the generation of new neurons in the brain.

15 Feb 2021

Cell cycle of cancer cells can be disrupted using two commercially available inhibitors

With two commercially available inhibitors, the cell cycle of the cancer cells in the childhood tumor neuroblastoma can be disrupted at a key point causing tumor cell death.

12 Feb 2021

N-terminal acetylation shields proteins from degradation and inhibits programmed cell death

A new study shows that proteins called IAPs, which can trigger programmed cell death, are inhibited by a specific chemical modification, and reveals that they play a wider role in protein quality control than previously assumed.

11 Feb 2021

Study provides a causal link between the Alzheimer's risk gene and COVID-19

A City of Hope-led research team found that the same gene that increases the risk for Alzheimer's disease, ApoE4, can increase the susceptibility to and severity of COVID-19.

5 Feb 2021

New method shows how pharmaceuticals induce cancer cell death

Cancer cells are smart when it comes to anti-cancer drugs, evolving and becoming resistant to even the strongest chemotherapies over time.

20 Jan 2021

Targeting RNA splicing can trigger antiviral immune pathways in triple-negative breast cancers

Researchers at Baylor College of Medicine have discovered how therapeutics targeting RNA splicing can activate antiviral immune pathways in triple negative breast cancers (TNBC) to trigger tumor cell death and signal the body's immune response.

15 Jan 2021

Anti-diarrhea drug could be used to induce cell death in glioblastoma cell lines

The research group led by Dr Sjoerd van Wijk from the Institute of Experimental Cancer Research in Paediatrics at Goethe University already two years ago found evidence indicating that the anti-diarrhea drug loperamide could be used to induce cell death in glioblastoma cell lines.

23 Dec 2020

Researchers demonstrate potential preventive treatment for Crohn's disease

A potential preventive treatment for Crohn's disease, a form of inflammatory bowel disease, has been demonstrated in a mouse model and using immune-reactive T cells from patients with Crohn's disease.

22 Dec 2020

Study may lead to new treatments for certain types of disease

Researchers at the Francis Crick Institute have found a new way to prevent some tumours from repairing their own DNA, a function that is essential for cancer cell survival. This discovery could lead to much needed new treatments for certain types of the disease.

17 Dec 2020

Repair proteins can help healthy cells to avoid damage during cancer therapy

A key way radiation therapy and chemotherapy work is by making highly lethal double-strand breaks in the DNA of cancer cells.

10 Dec 2020

Researchers discover molecular mechanism of plant immune receptors

In a recent study, Alexander von Humboldt Professor Jijie Chai at the University of Cologne and his team together with MPIPZ researchers have succeeded for the first time in reconstructing the sequence of molecular events that activate an inactive plant immune receptor and thus mediate the death of the host cell.

8 Dec 2020