Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Researchers identify a new method to synthesize miniaturized antibodies

Scientists have identified a new method to synthesize miniaturized antibodies, paving the way for a promising new class of therapies for various diseases.

From University of Bath 30 Sep 2020

New precision drug targeting cancer's ability to repair DNA shows promise

A new precision drug which stops cancer from repairing its DNA has shown promise in an early-stage clinical trial - highlighting the potential of a new class of drugs known as ATR inhibitors.

29 Sep 2020

Scientists Kill Cancer Cells By 'Shutting The Door' To The Nucleus

Scientists have shown that blocking the construction of nuclear pores complexes shrank aggressive tumors in mice while leaving healthy cells unharmed.

29 Sep 2020

Scientists use cryo-EM method to extract molecular data

Scientists have made enormous strides in the field of structural biology, looking into the activities of nature at the smallest scale.

24 Sep 2020

How do hallucinogenic drugs exert their actions on the brain?

Not much is known about the fundamental mechanisms in the brain of hallucinogenic drugs and the way they induce their hallucinogenic effects.

21 Sep 2020

CRISPR in a Box: New educational gene editing tool kit

Introducing CRISPR in a Box™ - it's not a new crunchy cereal or the latest snack - it's an educational tool kit consisting of state-of-the-science gene editing technology that could be coming to a school near you.

10 Sep 2020

Study highlights the role of brain astrocyte cells in Parkinson's disease pathology

A new study using induced pluripotent stem cell (iPSC) technology links astrocyte dysfunction to Parkinson's disease (PD) pathology.

9 Sep 2020

New study shows how tumor cells evade the immune system

If cancer is a series of puzzles, a new study pieces together how several of those puzzles connect to form a bigger picture.

3 Sep 2020

Hydrophilic Vyon® plastics demonstrate outstanding performance for drug discovery applications

Porvair Sciences reports on testing that demonstrates how its hydrophilic Vyon® porous plastics exhibit outstanding performance in drug discovery applications due to the high hydrophilic void volume conversion of the materials’ pore structure after a special treatment process.

From Porvair Sciences Limited 2 Sep 2020

New method to synthesize complex bioactive molecules quickly and efficiently

Many modern medicines, including analgesics and opioids, are derived from rare molecules found in plants and bacteria.

28 Aug 2020

Drug-like compounds previously developed to fight SARS may also work against COVID-19

An extensive search and testing of current drugs and drug-like compounds have revealed compounds previously developed to fight SARS might also work against COVID-19.

28 Aug 2020

Protein structural study may lead to more improved research on disease development

Researchers had identified an actin cytoskeketal nucleator, called Arp2/3 complex, more than 20 years ago.

26 Aug 2020

New technique could accelerate drug research for various diseases

Alicyclic compounds are groups of organic chemical compounds that have led to the development of a number of medications.

19 Aug 2020

HPSC-based disease modeling can help treat heart diseases

A team of researchers has reported a article relating to human pluripotent stem cell-derived cardiomyocytes in the modeling and repair of heart disease.

11 Aug 2020

Researchers use genome editing to facilitate drug discovery based on natural fungus

Rice University scientists have won federal support for their pursuit of novel drugs to treat human disease.

11 Aug 2020

Researchers are developing therapeutic treatments for acute stroke

Every year in the United States, about 800,000 people experience a stroke. Many are left with neurological complications such as paralysis on one side of the body, speech and language problems, vision issues, behavioral changes, and memory loss.

10 Aug 2020

Machine learning can increase effectiveness of drug repurposing for psychiatric disorders

Artificial intelligence can increase the effectiveness of drug repositioning or repurposing research, according to a study published in Translational Psychiatry.

4 Aug 2020

Sterile deep well plates

Porvair Sciences offers an extensive range of sterile deep well microplates for sensitive biological and drug discovery applications.

From Porvair Sciences Limited 4 Aug 2020

A simple screening process may improve mAb-based drug development

By screening potential monoclonal antibody (mAb)-based drugs solely based on a measure of their colloidal stability, scientists may be able to weed out mAbs that do not respond efficiently in solution early in the drug discovery process, according to a new study.

3 Aug 2020

A new cell-based gene therapy approach to correct hemophilia A

In a new study from the Wake Forest Institute for Regenerative Medicine (WFIRM) researchers have developed an optimized cellular platform for delivering Factor 8 to better treat patients with hemophilia A.

29 Jul 2020