Drug Discovery and Manufacturing News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Further Reading

Using light to control the viability and mobility of individual cells

Using light to control the viability and mobility of individual cells

Photopharmacology is the study that examines the use of light to change the impact of drugs on and off. For the first time, researchers from Jena, Munich, and New York have successfully applied this technique to regulate a component of cells that was earlier believed to be inaccessible.

18 May 2020

Leap Forward In The Discovery And Development Of New Antibiotics

Leap Forward In The Discovery And Development Of New Antibiotics

A powerful new insight, linked to recent studies, has provided a new understanding of Glycopeptide antibiotics biosynthesis that allows new GPAs to be made.

18 May 2020

Determining effect of drugs in pancreatic islets through single-cell RNA-seq approach

Determining effect of drugs in pancreatic islets through single-cell RNA-seq approach

Scientists have developed a technique to assess the impact of particular drugs in pancreatic tissues by using an advanced single-cell RNA sequencing approach.

12 May 2020

Researchers discover new therapeutic targets for cancer, male infertility

Researchers discover new therapeutic targets for cancer, male infertility

Researchers analyzed 13,000 tumors, highlighting two formerly overlooked genes as promising new therapeutic targets for treating cancer.

7 May 2020

Project Expands Use Of Metal Catalysts For Drug Discovery

Project Expands Use Of Metal Catalysts For Drug Discovery

The use of metals in drug delivery could offer major benefits, including allowing for lower dosages of a medication to achieve therapeutic effects.

7 May 2020

Cholesterol Lowering Drugs Linked To Improved Gut Bacteria Composition In Obese People

Cholesterol Lowering Drugs Linked To Improved Gut Bacteria Composition In Obese People

The human gut microbiota consists of bacteria, fungi, and viruses constituting an inner chemical factory producing a multitude of microbial compounds.

7 May 2020

Bacterial Enzyme Activity Could Lead To New Sugar-Based Drugs

Bacterial Enzyme Activity Could Lead To New Sugar-Based Drugs

Researchers from DTU Biosustain and DTU Bioengineering have elucidated the activity of the enzyme GH109 whose mechanism of activity has been a mystery.

5 May 2020

Researchers Develop 'Piggyback' Method To Improve Drug Delivery

Researchers Develop 'Piggyback' Method To Improve Drug Delivery

A group of researchers has developed a new way to deliver molecules that target specific genes within cells.

4 May 2020

Exploiting A Chink In The Armor Of Bacteria Could Result In New Drug Therapies

Exploiting A Chink In The Armor Of Bacteria Could Result In New Drug Therapies

Scientists have identified a key process in the way bacteria protect themselves from attack, and it heralds a new strategy in the hunt for antibiotics.

1 May 2020

Better Understanding Of Nature's Nanomachines May Help In Design Of Future Drugs

Better Understanding Of Nature's Nanomachines May Help In Design Of Future Drugs

Many of the drugs and medicines that we rely on today are natural products taken from microbes like bacteria and fungi.

1 May 2020

Fecal Transplantation Improves Outcomes In Patients With Multi-Drug Resistant Organisms

Fecal Transplantation Improves Outcomes In Patients With Multi-Drug Resistant Organisms

Transferring fecal matter from the digestive systems of healthy donors to ill patients with drug-resistant bacteria resulted in shorter hospital stays.

30 Apr 2020

COVID-19: A Wake-Up Call To Rebalance The Drug Supply Chain?

COVID-19: A Wake-Up Call To Rebalance The Drug Supply Chain?

Over 80% of chemicals used to make pharmaceuticals sold in Europe originate from China or India, according to the European Fine Chemicals Group.

30 Apr 2020

Variation In How Side Effects Are Reported Clouds Drug Safety

Variation In How Side Effects Are Reported Clouds Drug Safety

A goal of early-phase clinical trials is to discover a drug's possible side effects. But there is significant variation in how drug side effects are reported.

29 Apr 2020

Researchers study the evolution of multidrug-resistant bacteria

Researchers study the evolution of multidrug-resistant bacteria

Although antibiotics are known to save lives, their use also supports the evolution and spread of antibiotic-resistant strains.

29 Apr 2020

Study finds utrophin-based therapy could be used to treat Duchenne muscular dystrophy

Study finds utrophin-based therapy could be used to treat Duchenne muscular dystrophy

If an actor is not in a position to perform in the theatre, an understudy—preferably one with some practice in the role—can take that role on stage.

27 Apr 2020

AI accelerates drug discovery to fight COVID-19

AI accelerates drug discovery to fight COVID-19

A global race is underway to discover a vaccine, drug, or combination of treatments that can disrupt the SARS-CoV-2 virus, which causes the COVID-19 disease, and prevent widespread deaths.

24 Apr 2020

In Glowing Colors: Seeing The Spread Of Drug Particles In A Forensic Lab

In Glowing Colors: Seeing The Spread Of Drug Particles In A Forensic Lab

When two scientists from NIST brought black lights and glow powder into the crime lab, they were not setting up a laser tag studio or nightclub.

From National Institute of Standards and Technology (NIST) 24 Apr 2020

Designing Peptide Inhibitors For Possible COVID-19 Treatments

Designing Peptide Inhibitors For Possible COVID-19 Treatments

Scientists across the globe are rushing to find inhibitors of SARS-CoV-2, the new coronavirus behind the COVID-19 pandemic.

20 Apr 2020

Super-Charging Drug Development For COVID-19

Super-Charging Drug Development For COVID-19

Researchers are ramping up production of a promising drug that has proven effective in obliterating SARS-CoV in cellular cultures.

17 Apr 2020

Computer Model Predicts How Drugs Affect Heart Rhythm

Computer Model Predicts How Drugs Affect Heart Rhythm

UC Davis Health researchers have developed a computer model to screen drugs for unintended cardiac side effects, especially arrhythmia risk.

From The University of California, Davis 17 Apr 2020

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