Immunotherapy News and Research

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Immunotherapy is the concept of using the immune system to treat disease, for example, developing a vaccine against cancer. Immunotherapy may also refer to the therapy of diseases caused by the immune system, allergies for example.

Newly developed radio-labeled molecule may be able to pinpoint areas of inflammation

Researchers at The University of Texas MD Anderson Cancer Center have developed a new radio-labeled molecule capable of selectively reacting with certain high-energy radicals that are characteristic of innate immune activity, which may allow a non-invasive approach to monitor inflammation in real time by positron emission tomography (PET) imaging.

22 Feb 2022

Study highlights how IL-2 regulates developmental bifurcation

The immune system is a complicated network of cells and proteins that performs a straightforward function—protecting the body against infection.

15 Feb 2022

Immune cells leave traces on metastasis in the brain, likely to help future treatments

Researchers from the University of California San Francisco discovered two functional archetypes of metastatic cells spanning seven different types of brain cancers.

14 Feb 2022

Novel method can report specific immune cell types using only DNA from blood

Flow cytometry is a powerful and complex technology used to count, sort or measure characteristics of cells and to detect biomarkers.

10 Feb 2022

Scientists use CRISPRa to discover genes that play a role in immune cell biology

CRISPR genome editing has served as a powerful tool for deleting or altering DNA sequences and studying the resulting effect.

4 Feb 2022

Leukemia-on-a-chip; The Future of Preventing Therapy Resistance?

We speak to Dr. Chao Ma, one of the speakers at SLAS 2022, about his groundbreaking 'leukemia-on-a-chip' technology and its future within therapy resistance.

From Society for Laboratory Automation and Screening (SLAS) 27 Jan 2022

Researchers reveal molecular and cellular mechanisms that lead to tertiary lymphoid structures formation

Tertiary lymphoid structures are formations that occur outside of the lymphatic system. They contain immune cells and are similar in structure and function to lymph nodes and other lymphoid structures.

12 Jan 2022

CAR T cells produced in vivo using modified mRNA treat cardiac injury

A new study by researchers from the University of Pennsylvania shows that experimental immunotherapy can temporarily reprogram the immune cells of patients.

10 Jan 2022

Research provides novel insights on cancer immunotherapy

UC San Francisco researchers have defined 12 classes of “immune archetypes” to identify cancer tumors based on data from over 300 patient tumors.

10 Jan 2022

In vivo generation of engineered CAR T cells to treat heart injury

A novel immunotherapy strategy using in vivo generation of transient engineered chimeric antigen receptor (CAR) T cells, through the delivery of modified mRNA, can reduce fibrosis and restore cardiac function in a mouse model of heart failure, researchers report.

7 Jan 2022

A folic acid-like drug changes a DNA process within brain tumors

A folic acid-like drug, L-methylfolate, when administered alongside the standard therapy for patients with recurrent glioblastoma, changed aDNA process within their brain tumors, according to results from a phase 1 clinical trial.

From Vanderbilt University 6 Jan 2022

Driving up the immune response at tumor site may help boost immunotherapy

Driving up the immune response at the site of a cancer tumor with nanotechnology may help enhance immunotherapy treatments in advanced stages of the disease, new research in mice suggests.

15 Dec 2021

Study helps identify how immune system cells identify and eradicate tumors

In the last 10 years, immunotherapy has been used to save the lives of several cancer patients with lung cancer.

13 Dec 2021

Single-cell spatial analysis may provide information about neoadjuvant therapy for triple-negative breast cancer

A next-generation technology that allows the study of protein expression at the single-cell level and the location of the cells within the tumor microenvironment (TME) was feasible and provided information on the benefit of adding the immune checkpoint inhibitor atezolizumab (Tecentriq) to chemotherapy as neoadjuvant treatment for patients with early high-risk and locally advanced triple negative breast cancer (TNBC), according to results presented at the San Antonio Breast Cancer Symposium, held December 7-10, 2021.

8 Dec 2021

New strategy to improve the therapeutic efficacy of liver cancer immunotherapy

In recent years, tumor immunotherapy has emerged as a highly promising and much-touted oncological approach.

8 Dec 2021

Lunaphore highlights novel spatial biology research at SITC 2021

Lunaphore today announced new research from collaborators at the University of Birmingham.

From Lunaphore 7 Dec 2021

Study identifies genes that protect ovarian cancer from antitumor immunity

Immunotherapies are exhibiting better clinical benefit in the treatment of numerous cancers, particularly when used along with chemotherapy.

2 Dec 2021

Treatment with common allergy medication linked to improved immunotherapy response

New research from The University of Texas MD Anderson Cancer Center found that treatment with antihistamines, a commonly used allergy medication, was associated with improved responses to immune checkpoint inhibitors.

29 Nov 2021

Researchers expand understanding of how T cells recognize infections or disease

T cells communicate with other cells in the body in search of infections or diseases. This crosstalk relies on specialized receptors known as T cell receptors that recognize foreign molecular fragments from an infection or cancer that are presented for detection by particular molecules called major histocompatibility complex (MHC) or MHC-like.

23 Nov 2021

MIT researchers identify a way to indirectly activate T cells to fight tumors

Under the right circumstances, the body's T cells can detect and destroy cancer cells. However, in most cancer patients, T cells become disarmed once they enter the environment surrounding a tumor.

22 Nov 2021