Inflammation News and Research

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Researchers identify new potential drug target that may block SARS-CoV-2 infection

In the quest for new treatments for COVID-19, a team led by researchers at UC San Francisco has identified a new potential drug target that may block infection by SARS-CoV-2. The protein, called BRD2, regulates the ACE2 receptor, which the novel coronavirus relies on to gain entry to its host's cells.

17 Jan 2022

Targeting the inflamed intestinal wall may be a novel way to prevent inflammation in HIV patients

New UCLA-led research in mice suggests that adding a certain type of tomato concentrate to the diet can reduce the intestinal inflammation that is associated with HIV. Left untreated, intestinal inflammation can accelerate arterial disease, which in turn can lead to heart attack and stroke.

13 Jan 2022

Increasing the expression of a gene slows Alzheimer’s progression in mice

According to a recent research, enhancing the expression of one gene in cells that help the brain’s neurons, shields neurons in mouse models of Alzheimer’s disease.

13 Jan 2022

Scientists develop DNA-based fluorescent nanoantenna to evaluate protein activity

Researchers at the Université de Montréal have developed a nanoantenna to track protein movements.

13 Jan 2022

Pyroptosis is not a one-way ticket, it can be halted and controlled

A study published by researchers at the University of Illinois Chicago describes a new method for analyzing pyroptosis -; the process of cell death that is usually caused by infections and results in excess inflammation in the body -; and shows that process, long thought to be irreversible once initiated, can in fact be halted and controlled.

11 Jan 2022

CAR T cells produced in vivo using modified mRNA treat cardiac injury

A new study by researchers from the University of Pennsylvania shows that experimental immunotherapy can temporarily reprogram the immune cells of patients.

10 Jan 2022

Researchers identify molecules responsible for dangerous neutrophil behavior

Researchers have found that circulating neutrophils—a kind of immune cell—acquire distinct behavior patterns during inflammatory processes.

7 Jan 2022

A highly effective protection against oxidative stress developed by present-day humans

Very few proteins in the body have a change that makes them unique compared to the corresponding proteins in Neanderthals and apes. Researchers at the Max Planck Institute for Evolutionary Anthropology in Germany and Karolinska Institute in Sweden have now studied one such protein, glutathione reductase, which protects against oxidative stress.

From The Max Planck Institute 6 Jan 2022

New model system reveals how tiny bacteria from the environment have adapted to live inside humans

The microbes that live inside our mouths, collectively known as the oral microbiome, impact our overall health in many ways that are not yet fully understood.

4 Jan 2022

Blocking function of blood-clotting protein prevents bone loss from gum disease in mice

Blocking function of a blood-clotting protein prevented bone loss from periodontal (gum) disease in mice, according to research led by scientists at the National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health.

24 Dec 2021

People with inflammatory bowel disease have more fecal microplastics

Microplastics -; tiny pieces of plastic less than 5 mm in length –– are everywhere, from bottled water to food to air. According to recent estimates, people consume tens of thousands of these particles each year, with unknown health consequences.

23 Dec 2021

Study identifies novel function for existing protein

Researchers recently identified a new role of the protein tBID, which was to date linked to the regulatory role in cancer and cell death. But tBID also directly mediates apoptosis (controlled cell death).

23 Dec 2021

Gene mutation for Parkinson's disease drives mislocalization of iron in activated microglia

A common gene mutation for Parkinson's disease drives mislocalization of iron in activated microglia, according to a new study publishing December 16th in the open-access journal PLOS Biology, by Mark Cookson of the National Institute on Aging and colleagues.

17 Dec 2021

Researchers develop novel technique to monitor remote immune mechanisms

The human immune system works hard to maintain an individual’s health and protect against viruses, bacteria, parasites, fungi, and cancerous cells.

17 Dec 2021

Genetic mutation appears to be a predisposing factor for COPD independent of smoking

In 2019, the WHO positioned chronic obstructive pulmonary disease (COPD) third in the global ranking of causes of death.

From Institut Pasteur 15 Dec 2021

Researchers identify toxic senescent cells in the brain as potential target for Alzheimer’s treatment

For the first time, scientists have identified a rare population of potentially toxic senescent cells in human brains that can serve as a target for a new Alzheimer's disease treatment.

13 Dec 2021

Research offers alternative cell option for organs-on-chips

Organ-on-a-chip technology has provided a push to discover new drugs for a variety of rare and ignored diseases for which current models either don't exist or lack precision. In particular, these platforms can include the cells of a patient, thus resulting in patient-specific discovery.

13 Dec 2021

Study reveals bacterial signature that marks the shift from healthy teeth, gums to periodontitis

When you're smiling, the whole world smiles with you; but what happens when gum or tooth disease starts to dim your pearly whites? Now, researchers from Japan have found a bacterial signature that marks the shift from healthy teeth and gums to periodontitis.

8 Dec 2021

Cancer drug effective against Alzheimer’s disease, says research

According to recent research carried out by researchers from the Weill Cornell Medicine, a gene mutation associated with Alzheimer’s disease changes a signaling pathway in specific immune cells of individuals with the disease.

7 Dec 2021

New nanoparticle adjuvant could lead to more powerful vaccines

A common strategy to make vaccines more powerful is to deliver them along with an adjuvant -; a compound that stimulates the immune system to produce a stronger response.

6 Dec 2021

Inflammation News and Research

Researchers identify new potential drug target that may block SARS-CoV-2 infection

Targeting the inflamed intestinal wall may be a novel way to prevent inflammation in HIV patients

Increasing the expression of a gene slows Alzheimer’s progression in mice

Scientists develop DNA-based fluorescent nanoantenna to evaluate protein activity

Pyroptosis is not a one-way ticket, it can be halted and controlled

CAR T cells produced in vivo using modified mRNA treat cardiac injury

Researchers identify molecules responsible for dangerous neutrophil behavior

A highly effective protection against oxidative stress developed by present-day humans

New model system reveals how tiny bacteria from the environment have adapted to live inside humans

Blocking function of blood-clotting protein prevents bone loss from gum disease in mice

People with inflammatory bowel disease have more fecal microplastics

Study identifies novel function for existing protein

Gene mutation for Parkinson's disease drives mislocalization of iron in activated microglia

Researchers develop novel technique to monitor remote immune mechanisms

Genetic mutation appears to be a predisposing factor for COPD independent of smoking

Researchers identify toxic senescent cells in the brain as potential target for Alzheimer’s treatment

Research offers alternative cell option for organs-on-chips

Study reveals bacterial signature that marks the shift from healthy teeth, gums to periodontitis

Cancer drug effective against Alzheimer’s disease, says research

New nanoparticle adjuvant could lead to more powerful vaccines

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