Malignant News and Research

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Developing a 'Trojan Horse' nanotherapy to fight breast cancer

With a nearly $2.6 million grant from the National Institutes of Health, Michigan State University researchers are using nanoscopic particles to turn the body's own cells into weapons that cancer won't see coming.

12 Oct 2020

Study shows thymoquinone compound selectively kills prostate cancer cells

According to a new study reported in the Oncogene journal, the thymoquinone (TQ) compound selectively destroys prostate cancer cells at advanced phases.

9 Oct 2020

Type and direction of force on a cell can alter gene expression

Tissues and cells in the human body are subjected to a constant push and pull - strained by other cells, blood pressure and fluid flow, to name a few.

5 Oct 2020

Memory training for the immune system

After an infection of the human body with a pathogen, a cascade of reactions will usually be set into motion.

29 Sep 2020

Enhancing the effectiveness of immunotherapy against melanoma

Researchers at the University of Bern have discovered a mechanism in the body’s own immune system which is responsible for the maturation and activation of immune cells.

21 Sep 2020

Study sheds new light on the structure and function of ‘immortality protein’

The nuclear magnetic resonance spectrometer of Kazan Federal University played a crucial role in analyzing the telomerase of Hansenula polymorpha.

14 Sep 2020

New technology reveals experimental drugs that help suppress the growth and spread of tumor

A new technology that allows researchers to peer inside malignant tumors shows that two experimental drugs can normalize aberrant blood vessels, oxygenation, and other aspects of the tumor microenvironment in non-small cell lung cancer (NSCLC), helping to suppress the tumor's growth and spread, UT Southwestern researchers report.

4 Sep 2020

Researchers discover the developmental process of strong immune T-cells

There are memory cells that remember previously encountered pathogens and help to react quickly and strongly when exposed to them again.

4 Sep 2020

Researchers discover the developmental process of novel immune T cells

Memory cells essentially recall formerly encountered pathogens and help respond strongly and rapidly when they are exposed to this foreign matter again.

3 Sep 2020

DNA repair enzymes offer potential drug targets for personalized cancer therapies

Chemical lesions in the genetic material DNA can have catastrophic consequences for cells, and even for the organism concerned.

28 Aug 2020

Study shows Annexin molecule promotes resistance to anticancer drugs

Headed by Kumamoto University (Japan), a collaborative study has identified a novel mechanism for anticancer drug resistance in gastric cancer.

24 Aug 2020

A metabolic enzyme could be potential target for immunotherapies

The metabolic enzyme IL4I1 (Interleukin-4-Induced-1) promotes the spread of tumor cells and suppresses the immune system.

21 Aug 2020

Extrachromosomal DNA with potential to cause cancer drives poor patient outcomes

The multiplication of genes located in extrachromosomal DNA that have the potential to cause cancer drives poor patient outcomes across many cancer types, according to a Nature Genetics study published Aug. 17, 2020 by a team of researchers including Professors Vineet Bafna and Dr.Paul Mischel of the University of California San Diego and Professor Roel Verhaak of Jackson Laboratories.

From UC San Diego 18 Aug 2020

Genome analysis helps identify 568 cancer driver genes

Analysis of the genomes of 28,000 tumors from 66 types of cancer has led to the identification of 568 cancer driver gene.

18 Aug 2020

Hydrogels based on modified pectins could be used for neural tissue restoration

Far Eastern Federal University (FEFU) scientists have developed implantable hydrogels based on plant polysaccharides (pectins). They can play the role of an artificial extracellular matrix, a special network of molecules that fills the space between body cells.

14 Aug 2020

Genetic analysis reveals the inhibitory role of NSD2 enzyme in cellular senescence

Using a detailed genetic analysis, a research team from Japan-based Kumamoto University has discovered that the NSD2 enzyme, which controls the actions of several genes, also functions to block the aging of cells.

10 Aug 2020

Researchers use mathematical modeling to unravel the mechanisms behind tetraploidy

Cell division is a fundamental process that organisms need to reproduce, grow, and make repairs. But when an error disrupts this complex biological process, cellular abnormalities can lead to diseases, such as cancer, where cells are enabled to grow and divide out of control.

27 Jul 2020

Clinical trial shows CAR-T cell therapy can be used for treating Hodgkin lymphoma

CAR-T cell therapy, which attacks cancer cells using a person's reprogrammed immune cells, has been used to treat Hodgkin lymphoma with remarkable success for the first time, according to the results of an early phase clinical trial led by researchers at UNC Lineberger Comprehensive Cancer Center and Baylor College of Medicine in Houston.

24 Jul 2020

Study reveals key factor that influences malignant cells to develop into tumor

Researchers have unraveled a crucial factor that governs whether malignant cells will develop into a tumor. The study was recently published in the eLife journal.

22 Jul 2020

Josep Carreras Institute creates spin-off to develop CAR-T based therapies for leukemia

The Josep Carreras Leukaemia Research Institute, a public centre pertaining to the Generalitat de Catalunya's (Government of Catalonia) CERCA network, has created the OneChain Immunotherapeutics spin-off, the aim of which is to develop new immuno-oncological therapeutic tools with various preclinical candidates, based on CAR-T technology for different tumors, such as cortical T-cell acute lymphoblastic leukemia (coT-ALL), a rare subtype of leukemia that mainly affects children, and which has a poor prognosis.

21 Jul 2020