Nucleotide News and Research

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Carrying out CRISPR/Cas9 in Space

In our latest interview, AZoLifeSciences spoke to a team of researchers about their latest research which involved carrying out CRISPR/Cas9 in Space.

8 Jul 2021

Protein's 'silent code' influences cell movement

The protein actin is ubiquitous and essential for life. In mammals, every cell expresses two of its forms, beta-actin and gamma-nonmuscle-actin. Despite having distinct roles, the two forms are nearly identical, sharing 99% of their amino acid sequence.

8 Jul 2021

Refreshers develop new DNA sequencing method

An international research team headed by Michal Hocek of the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) and Charles University and Ciara K. O'Sullivan of Universitat Rovira i Virgili (URV) in Spain have developed a novel method for labeling DNA, which in the future can be used for sequencing DNA by means of electrochemical detection.

18 May 2021

Researchers sequence genome of raccoon dogs that are reservoir hosts for coronaviruses

For the first time, a research team has sequenced the genome of a raccoon dog. Genetic data now supports the animal’s ability to spread SARS-CoV-2.

6 May 2021

New gene therapy could help treat Duchenne muscular dystrophy

Researchers from UT Southwestern used a new kind of gene therapy to successfully treat mice with Duchenne muscular dystrophy (DMD), distinctively employing CRISPR-Cas9-based tools to restore a large section of the dystrophin protein missing in several DMD patients.

3 May 2021

Shortage of DNA building blocks triggers inflammation

Mitochondria are the energy suppliers of our body cells. These tiny cell components have their own genetic material, which triggers an inflammatory response when released into the interior of the cell.

3 May 2021

Inhibiting a specific protein could increase tumor sensitivity to PARP inhibitors

Researchers at the Francis Crick Institute have found that blocking a specific protein could increase tumor sensitivity to treatment with PARP inhibitors. Their work published in Science , suggests combining treatments could lead to improved therapy for patients with inheritable breast cancers.

9 Apr 2021

Researchers take a key step toward new drugs and vaccines for combating COVID-19

Scientists have achieved a huge step toward new vaccines and drugs for fighting against COVID-19.

6 Apr 2021

New CRISPR-SNP-Chip technology detects single-point mutations without amplification

The CRISPR-Chip technology was first introduced in 2019 by Dr. Kiana Aran, an Assistant Professor at Keck Graduate Institute (KGI).

6 Apr 2021

New research aims to take the study of the human genome to the next level

A global consortium of biologists, geneticists, mathematicians, clinicians, and other scientists is all set to elevate the study of the human genome to the next level—developing an exhaustive atlas of genetic variants to improve the understanding, diagnosis, and treatment of disease.

2 Apr 2021

Supercomputer simulations help uncover the mechanism for HIV replication

Viruses lurk in the grey area between the living and the nonliving, according to scientists. Like living things, they replicate but they don't do it on their own. The HIV-1 virus, like all viruses, needs to hijack a host cell through infection in order to make copies of itself.

1 Apr 2021

Gender difference accounts for major psychiatric disorders

According to an analysis of sex variations in the genetics of bipolar disorder, schizophrenia, and major depressive disorders.

24 Mar 2021

Rare genetic variants contribute to increased risk for lung cancer

In the United States, lung cancer is the main cause of cancer death in both male and female populations.

19 Mar 2021

New gene editor could help treat genetic disorders caused by single-nucleotide mutations

Scientists have created a CRISPR-based gene editor named C-to-G Base Editor (CGBE) that can correct mutations responsible for genetic disorders.

15 Mar 2021

RNA-editing events can reveal the genetic basis of many human diseases

Scientists from CHOP have detected RNA-editing events that affect the expression of genes and the phenotypic manifestation of that specific expression.

10 Mar 2021

Two new Alzheimer’s genes discovered

AZoLifeSciences speaks to researchers from Tianjin Medical University about their latest research that led to the discovery of two new genes that are linked to Alzheimer's disease.

From Tianjin Medical University 1 Mar 2021

Unusual DNA folding leads to higher mutation rates

DNA sequences that can fold into shapes other than the classic double helix tend to have higher mutation rates than other regions in the human genome.

From Penn State University 10 Feb 2021

Researchers identify a new way to stop COVID-19 virus

While the world awaits broad distribution of COVID-19 vaccines, researchers at Ohio University just published highly significant and timely results in the search for another way to stop the virus -- by disrupting its RNA and its ability to reproduce.

22 Jan 2021

Newly identified Cas9 nucleases can improve genome editing

Scientists have explained two new compact Cas9 nucleases that will possibly extend the Cas9 toolbox for genome editing.

11 Dec 2020

Research clarifies regulatory impacts of ubiquitin-proteasome system on DNA damage repair

An international research team has clarified the regulatory mechanism of the ubiquitin-proteasome system (*1) in recognizing and repairing DNA that has been damaged by ultraviolet (UV) light.

9 Dec 2020