Proliferation News and Research

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Researchers create molecular ON-OFF switches to regulate CAR T cell activity

CAR T cells are a breakthrough class of effective but often toxic cancer therapies. To prevent overactivation, switchable CAR T cells were engineered that can be turned on and off with an approved, widely used cancer drug.

7 Jan 2021

Scientists show how plants adapt root growth to varying sources of nitrogen

Nitrogen is one of the most essential nutrients for plants. Its availability in the soil plays a major role in plant growth and development, thereby affecting agricultural productivity.

6 Jan 2021

Transporter protein likely played a crucial role in vertebrate evolution

A transporter protein that regulates cell membrane cholesterol likely played an important role in vertebrate evolution, according to a review published by iCeMS researchers in the journal FEBS Letters.

24 Dec 2020

Scientists discover molecular defects associated with rare genetic disorder in children

Damien D'Amours and his team at the Ottawa Institute of Systems Biology needed three years to discover the molecular defects associated with the LIC Syndrome, a serious genetic disorder that affects young children and result in acute respiratory distress, immune deficiency and abnormal chromosomes.

23 Dec 2020

Biochemical methods reveal signal transduction mystery inside human pathogen

In order to adapt to the changing environment, bacteria must quickly transform extracellular information into appropriate intracellular reactions. Two component system (TCS) is the main signal transduction protein in prokaryotic cells to transform environmental stimuli into cellular responses.

16 Dec 2020

Study shed light on how genes affect the risk for coronary artery disease

Researchers at the University of Virginia have shed light on how our genes affect our risk for coronary artery disease, the most common form of heart disease.

11 Dec 2020

Researchers use new decoding method to identify novel proteins encoded by HSV-1

Comprehensive identification of viral proteins encoded by viral genes is required to understand the pathophysiology of viral infections.

8 Dec 2020

Mice infused with CD5-deleted CAR T cells showed significant reduction in tumor size

Knocking out a protein known to stifle T cell activation on CAR T cells using the CRISPR/Cas9 technology enhanced the engineered T cells' ability to eliminate blood cancers, according to new preclinical data from researchers in the Perelman School of Medicine at the University of Pennsylvania and Penn's Abramson Cancer Center.

8 Dec 2020

New model predicts potential outcomes for plants’ “investment” in roots

You might have observed plants competing for sunlight -- the way they stretch upwards and outwards to block each other's access to the sun's rays -- but out of sight, another type of competition is happening underground.

4 Dec 2020

Protein interactions could serve as therapeutic targets to treat viral infections

Researchers have investigated the role of the interplays within the proteins membranes of viral families involved in the control of programmed cell death.

30 Nov 2020

Pollution is partly linked to rapid proliferation of SARS-CoV-2 in the U.S.

The United States may have set itself up for the spread of a pandemic without even knowing it.

16 Nov 2020

Researchers identify key target to prevent viruses from disarming the human immune response

Viruses such as HIV, hepatitis B and hepatitis C evade or disrupt the immune system to create persistent infections.

11 Nov 2020

Dietary induction of hepatocyte regeneration could help enhance gene repair in the liver

The thyroid hormone used to promote the proliferation of hepatocytes improved the efficiency of CRISPR/Cas9-mediated gene repair in the mouse liver.

11 Nov 2020

Study may help develop new antiviral drugs against COVID-19

SARS-CoV-2 is a respiratory virus that is responsible for causing COVID-19 infection. It uses multiple steps to attack the body.

9 Nov 2020

New method to improve preclinical evaluation of CAR-T cell therapies

Ludwig Cancer Research scientists have developed a method to significantly improve the preclinical evaluation of chimeric antigen-receptor (CAR) T cell therapies.

9 Nov 2020

Study sheds new light on key protein implicated in tumor development

A study headed by the University of Colorado Boulder has revealed a specific protein that is crucial for regulating the growth, proliferation, and function of cells, and how these cells were long implicated in the development of tumors.

5 Nov 2020

Researchers use AI tool to study the dynamics behind cancer, Alzheimer’s disease

With the help of artificial intelligence (AI), scientists from the University of Copenhagen have solved a crucial issue that, to date, has been a major barrier to significant protein research into the dynamics behind various diseases, like Parkinson’s, Alzheimer’s, cancer, and also in the development of novel gene-editing techniques and sustainable chemistry.

4 Nov 2020

Reducing food intake can reduce risk of liver cancer caused by fatty liver

Liver cancer from too much fat accumulation in the liver has been increasing in many countries including Japan. In order to change this unfortunate state of affairs, it is important to improve the prognosis of non-alcoholic fatty liver disease.

2 Nov 2020

Scientists develop novel microcarrier for large-scale cell production

Researchers from Singapore-MIT Alliance for Research and Technology (SMART), MIT's research enterprise in Singapore, have developed a novel microcarrier for large-scale cell production and expansion that offers higher yield and cost-effectiveness compared to traditional methods, and reduces steps required in the cell retrieval process.

30 Oct 2020

Scientists discover new anti-cancer molecule

A group of Moscow scientists has discovered and explained the activity mechanism of a new anti-cancer molecule -- diphenylisoxazole. This molecule has been shown to be effective against human cancer cells. The research, published in the journal Bioorganic & Medicinal Chemistry Letters, makes it possible to produce an affordable cancer treatment drug.

30 Oct 2020