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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Study reveals mechanism by which ibuprofen prevents RAC1B alternative splicing in colorectal cells

Oncotarget published "Ibuprofen disrupts a WNK1/GSK3β/SRPK1 protein complex required for expression of tumor-related splicing variant RAC1B in colorectal cells" which reported that although the molecular mechanism behind the antitumor properties of NSAIDs has been largely attributed to inhibition of cyclooxygenases , several studies have shown that the chemopreventive properties of ibuprofen also involve multiple COX-independent effects.

23 Mar 2021

New genetic engineering strategy largely reduces tau protein levels in Alzheimer’s animal model

A genetic engineering approach has helped scientists to drastically decrease the levels of tau protein.

22 Mar 2021

Study advances CAR T cell therapy targeted at cancer

Cancer immunotherapy involves the activation of cells in the patient’s own immune system to fight tumor cells.

19 Mar 2021

Study identifies new biomarkers for the prognosis of gastric adenocarcinoma

A study headed by UCM reports that polymorphisms in gene TGFB1 and low plasma levels of protein TGFB1 serve as biomarkers for the gastric adenocarcinoma prognosis.

19 Mar 2021

Immune receptor proteins can help treat autoimmune diseases

TARM1 is a receptor protein, whose function in the working of the immune system is not known yet. Now, in a new research work, Japanese researchers have analyzed mouse models to investigate the promising role of TARM1 protein in the pathogenesis of rheumatoid arthritis.

From Tokyo University of Science 18 Mar 2021

New highly sensitive RNA detection method advances in situ transcriptomics

Human cells typically transcribe half of their roughly 20,000 genes into RNA molecules at any given time. Just like with proteins, the function of those RNA species not only relies on their abundance but also their precise localization within the 3D space of each cell.

18 Mar 2021

Researchers identify address codes in odorant receptor proteins for the first time

A team of scientists led by Dietmar Krautwurst from the Leibniz Institute for Food Systems Biology at the Technical University of Munich has now identified address codes in odorant receptor proteins for the first time.

18 Mar 2021

Scientists provide a complete phenotypic landscape of SCN2A-related disorders

Researchers from Children's Hospital of Philadelphia (CHOP) affiliated with the CHOP Epilepsy Neurogenetics Initiative (ENGIN) have compiled a complete genetic and clinical analysis of more than 400 individuals with SCN2A-related disorder, which has been linked to a variety of neurodevelopmental disorders, including epilepsy and autism.

18 Mar 2021

Study shows how human viruses are better adapted to infect certain tissues

The world’s first systematic study has explained how SARS-CoV-2 and other human viruses are more adapted to infect specific types of tissues..

17 Mar 2021

Study identifies novel mechanism by which hair follicles lose regenerative capabilities

Hair grows from stem cells residing in hair follicles. During aging, the capability of hair follicles to grow hair is successively lost, leading to hair thinning and ultimately hair loss.

17 Mar 2021

Key protein regulates cells’ innate defense mechanisms

Scientists from the University of Illinois Chicago (UIC) have found that heparanase (HPSE) is an important regulator of innate defense mechanisms of cells.

17 Mar 2021

High-resolution map of yeast genome can shed light on development responses in higher organisms

A new study explains an effort to create the most detailed and high-resolution map of gene regulation and chromosome architecture in yeast organisms.

15 Mar 2021

Lowering apolipoprotein CIII levels can prevent deleterious effects of a high-fat diet

Consumption of a diet with high fat levels increases the risk of fatty liver, obesity, cardiovascular diseases, and type 2 diabetes.

15 Mar 2021

ADAR1 protein offers a potential therapeutic target for cancer

A research team has discovered a new role of ADAR1 and found that the ADAR1p110 isoform controls genome stability at the ends of chromosomes.

15 Mar 2021

Cryogenic electron microscopy helps visualize 3D structure of complex responsible for gene regulation

A research team has looked inside a human cell to visualize a multi-subunit machine that is responsible for controlling the expression of genes.

15 Mar 2021

New gene editor could help treat genetic disorders caused by single-nucleotide mutations

Scientists have created a CRISPR-based gene editor named C-to-G Base Editor (CGBE) that can correct mutations responsible for genetic disorders.

15 Mar 2021

Optimized nano-micelles can induce efficient genome editing in mouse brain

A research team has reported that improved nano-micelles can trigger efficient genome editing in the mouse brain.

15 Mar 2021

Scientists reveal how critical enzyme in the cell works

S-acylation is the process of chemically linking a lipid to protein via a thioester bond. It is an important process of the cell that regulates the localization and function of numerous proteins.

12 Mar 2021

Researchers generate thyroid mini-organs in the lab

Hormones produced by the thyroid gland are essential regulators of organ function. The absence of these hormones either through thyroid dysfunction due to, for example, irradiation, thyroid cancer or autoimmune disease or thyroidectomy leads to symptoms like fatigue, feeling cold, constipation, and weight gain.

12 Mar 2021

Study reveals mechanisms behind the activation of MRN complex

Researchers from the Tokyo Institute of Technology have revealed mechanisms behind the stimulation of the MRN complex—the DNA scissors of the cells.

11 Mar 2021

Protein News and Research

Further Reading

Study reveals mechanism by which ibuprofen prevents RAC1B alternative splicing in colorectal cells

New genetic engineering strategy largely reduces tau protein levels in Alzheimer’s animal model

Study advances CAR T cell therapy targeted at cancer

Study identifies new biomarkers for the prognosis of gastric adenocarcinoma

Immune receptor proteins can help treat autoimmune diseases

New highly sensitive RNA detection method advances in situ transcriptomics

Researchers identify address codes in odorant receptor proteins for the first time

Scientists provide a complete phenotypic landscape of SCN2A-related disorders

Study shows how human viruses are better adapted to infect certain tissues

Study identifies novel mechanism by which hair follicles lose regenerative capabilities

Key protein regulates cells’ innate defense mechanisms

High-resolution map of yeast genome can shed light on development responses in higher organisms

Lowering apolipoprotein CIII levels can prevent deleterious effects of a high-fat diet

ADAR1 protein offers a potential therapeutic target for cancer

Cryogenic electron microscopy helps visualize 3D structure of complex responsible for gene regulation

New gene editor could help treat genetic disorders caused by single-nucleotide mutations

Optimized nano-micelles can induce efficient genome editing in mouse brain

Scientists reveal how critical enzyme in the cell works

Researchers generate thyroid mini-organs in the lab

Study reveals mechanisms behind the activation of MRN complex

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