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Scientists discover evolutionary lineage of SARS-CoV-2 virus

By reconstructing the evolutionary history of SARS-CoV-2, the virus that is responsible for the COVID-19 pandemic, an international research team of Chinese, European and U.S. scientists has discovered that the lineage that gave rise to the virus has been circulating in bats for decades and likely includes other viruses with the ability to infect humans.

29 Jul 2020

Highly invasive tumor cells have 'longer' finger-like projections

Tiny finger-like projections called filopodia drive invasive behavior in a rare subset of lung cancer cells, researchers at Winship Cancer Institute of Emory University have found.

28 Jul 2020

Heparin blocks SARS-CoV-2 infection in cell studies

In a test of antiviral effectiveness against the virus that causes COVID-19, an extract from edible seaweeds substantially outperformed remdesivir, the current standard antiviral used to combat the disease.

27 Jul 2020

Research identifies TLR7 gene that predisposes individuals to severe COVID-19

Current observations suggest that the coronavirus SARS-CoV-2 causes severe symptoms mainly in elderly patients with chronic disease.

27 Jul 2020

Experimental mRNA-based vaccine protects animals against SARS-CoV-2

An experimental messenger RNA (mRNA)-based vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) elicits protective immune responses in mice and non-human primates, researchers report on July 23rd in the journal Cell.

27 Jul 2020

Clinical trial shows CAR-T cell therapy can be used for treating Hodgkin lymphoma

CAR-T cell therapy, which attacks cancer cells using a person's reprogrammed immune cells, has been used to treat Hodgkin lymphoma with remarkable success for the first time, according to the results of an early phase clinical trial led by researchers at UNC Lineberger Comprehensive Cancer Center and Baylor College of Medicine in Houston.

24 Jul 2020

Study shows KBTBD2 gene plays a key role in regulating insulin sensitivity

Deleting a key gene in mice in just their fat made tissues throughout these animals insulin resistant, in addition to other effects, a new study by UT Southwestern researchers shows.

24 Jul 2020

New approach is more effective in treating certain blood cancers

Some of the most promising advances in cancer treatment have centered on immunotherapies that rev up a patient's immune system to attack cancer.

24 Jul 2020

Study reveals the degradation mechanism of endoplasmic reticulum

A team of researchers have analyzed the degradation mechanism of the endoplasmic reticulum (ER) called ER-phagy.

23 Jul 2020

Study shows efficacy of L-Grb2 in preclinical models of ovarian and uterine cancer

The cover for issue 29 of Oncotarget features Figure 5, "In vivo effects of treatment with L-Grb2 in combination with anti-angiogenic therapy in an ovarian tumor model," by Lara, et al. which reported that adaptor proteins such as growth factor receptor-bound protein-2 play important roles in cancer cell signaling.

23 Jul 2020

New startup launched to overcome the challenge of delivering next-generation therapeutics

Harvard University's Office of Technology Development (OTD) and the Harvard T.H. Chan School of Public Health today announced the launch of Vesigen Therapeutics, a startup company that aims to overcome the challenge of delivering next-generation therapeutics, such as gene-editing complexes, RNA molecules, and other large proteins, to intracellular targets in specific tissues of interest.

23 Jul 2020

Novel method of communication relies on 'mechano-chemical' signals to control cell movement

Cells work around the clock to deliver, maintain, and control every aspect of life. And just as with humans, communication is a key to their success.

23 Jul 2020

Study explains the compatibility of bacteria and virus in the human gut

The proverb “all things in moderation” holds good not only for food and drink but also for the cluster of microorganisms found inside the human gut.

22 Jul 2020

Fasting-mimicking diet combined with hormone therapy has potential to treat breast cancer

A USC-led team of scientists has found that a fasting-mimicking diet combined with hormone therapy has the potential to help treat breast cancer, according to newly published animal studies and small clinical trials in humans.

22 Jul 2020

Study shows how T cells become cancer-killing cells

Within the immune system, the T lymphocytes operate to kill cancer cells or infected cells.

21 Jul 2020

Newly discovered protein could be an important target to prevent prostate cancer metastases

Researchers from Boston University School of Medicine (BUSM) have discovered that the protein BRD4 could be an important new target to prevent castration-resistant prostate cancer metastases.

21 Jul 2020

Novel nano drug candidate kills triple negative breast cancer cells

Researchers at the University of Arkansas have developed a new nano drug candidate that kills triple negative breast cancer cells.

21 Jul 2020

UC Davis Health tests new antibody combination as potential treatment for COVID-19

Timothy Albertson, chair of internal medicine and specialist in pulmonary and critical care, is leading efforts at UC Davis Health to test a new antibody cocktail (REGN-COV2) as a prevention and treatment for COVID-19.

From The University of California, Davis 21 Jul 2020

Researchers find a way to prevent SARS-CoV-2 virus from binding to cells

On July 1, the Texas A&M Engineering Experiment Station's (TEES) National Center for Therapeutics Manufacturing (NCTM) received funding from the National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL) to help find a way to prevent the SARS-CoV-2 virus from binding to cells, protecting people from future infections.

20 Jul 2020

Blood vessels communicate with peripheral neurons to regulate neuronal differentiation

Researchers at Pompeu Fabra University have shown for the first time that blood vessels communicate with neurons in the peripheral nervous system, regulating their proliferation and differentiation.

17 Jul 2020

Receptor News and Research

Scientists discover evolutionary lineage of SARS-CoV-2 virus

Highly invasive tumor cells have 'longer' finger-like projections

Heparin blocks SARS-CoV-2 infection in cell studies

Research identifies TLR7 gene that predisposes individuals to severe COVID-19

Experimental mRNA-based vaccine protects animals against SARS-CoV-2

Clinical trial shows CAR-T cell therapy can be used for treating Hodgkin lymphoma

Study shows KBTBD2 gene plays a key role in regulating insulin sensitivity

New approach is more effective in treating certain blood cancers

Study reveals the degradation mechanism of endoplasmic reticulum

Study shows efficacy of L-Grb2 in preclinical models of ovarian and uterine cancer

New startup launched to overcome the challenge of delivering next-generation therapeutics

Novel method of communication relies on 'mechano-chemical' signals to control cell movement

Study explains the compatibility of bacteria and virus in the human gut

Fasting-mimicking diet combined with hormone therapy has potential to treat breast cancer

Study shows how T cells become cancer-killing cells

Newly discovered protein could be an important target to prevent prostate cancer metastases

Novel nano drug candidate kills triple negative breast cancer cells

UC Davis Health tests new antibody combination as potential treatment for COVID-19

Researchers find a way to prevent SARS-CoV-2 virus from binding to cells

Blood vessels communicate with peripheral neurons to regulate neuronal differentiation

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