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Supercoiling and looping can transmit mechanical stress along the DNA backbone, shows study

When people think of DNA, they visualize a string-like double helix structure. In reality, the DNA double helix in cells is supercoiled and constrained into loops. This supercoiling and looping are known to influence every aspect of DNA activity, but how this happens has not been clear.

28 Sep 2021

Study employs machine learning to predict outcomes in agriculture

Recent research emphasizes that machine learning can identify “genes of importance” that support crops to grow with reduced fertilizer.

From New York University (NYU) 28 Sep 2021

Scientists analyze the molecular machinery of poxviruses at an atomic level

Poxviruses have found a unique way of translating their genes into proteins in the infected organism. A team of researchers from Würzburg shows for the first time how the molecular machinery involved works at an atomic level.

24 Sep 2021

How does the KLF4 transcription factor influence gene expression?

Scientists have led a research group to identify a mechanism using which transcription factor KLF4 can influence gene expression.

24 Sep 2021

Genetic and epigenetic origin of pediatric liver cancer uncovered

Researchers at Hiroshima University have analyzed the molecular findings of almost 160 pediatric liver cancer cases and discovered molecular markers that should help to understand and treat the considerable variation in prognoses.

22 Sep 2021

Researchers seek to point a way toward a unified theory for DNA folding

At more than 2 meters long, the human DNA molecule uses intricate folding patterns to fit into cells while locally unfolding to express genes. Such phenomena, however, are difficult to measure in experiments, and theoretical frameworks explaining them continue to be at odds with one another.

22 Sep 2021

Study reveals how the tumor suppressor gene plays a vital role in pediatric rhabdomyosarcoma

Scientists at St. Jude Children's Research Hospital have revealed how the tumor suppressor gene PTEN plays a more important role in pediatric rhabdomyosarcoma than was previously appreciated.

20 Sep 2021

Researchers develop novel cell reprogramming strategy to slow down glioblastomas

Gliomas are the most common primary brain tumors in adults. Among them, high-grade glioblastomas (GBMs) are particularly known to be notoriously aggressive and invasive, which makes it challenging to treat them.

16 Sep 2021

Study uncovers mechanism where two transcription factors stabilize each other’s binding to DNA

Researchers have discovered an exclusive mechanism through which two transcription factors stabilize each other’s binding to DNA in fission yeast.

14 Sep 2021

Researchers develop a new method for monitoring organic pollutants using plants

Researchers at Kobe University's Biosignal Research Center have successfully developed plants that can be used to detect organic pollutants, such as polychlorinated biphenyls and endocrine-disrupting chemicals, which contaminate soil and water.

9 Sep 2021

Viruses buried in marsupials' DNA may help protect against future infections

Fossils of ancient viruses are preserved in the genomes of all animals, including humans, and have long been regarded as junk DNA. But are they truly junk, or do they actually serve a useful purpose?

From The University of New South Wales (UNSW) 9 Sep 2021

Study imparts mechanistic understanding on early stages of human cancer

Scientists demonstrated that normal human fibroblast cells can be converted to specific cancer cells through factors that are identified in actual human patients.

9 Sep 2021

Study unearths previously unknown role of CTCF, the transcription regulator

Researchers discovered evidence that CTCF governs chromatin accessibility, the mechanism of opening tightly spooled DNA facilitating gene expression.

9 Sep 2021

Study details how immature innate lymphoid cells become effector cells

During the invasion of pathogens into the human body, a prompt response is needed.

1 Sep 2021

Study identifies variants and genes linked to alcohol consumption

Scientists from the Icahn School of Medicine at Mount Sinai published the first of its kind research in the field of addiction genetics employing a multi-omics method to offer a huge list of causal candidate genes linked with alcohol consumption and alcohol use disorder (AUD).

24 Aug 2021

Genomic surveillance is vital to achieve effective mitigation and containment of COVID-19

Although the development and increasingly widespread availability of effective and safe vaccines provides the greatest hope for the future recovery from the increasingly devastating COVID-19 pandemic, genomic surveillance is emerging as a vital necessity to achieve effective mitigation and containment.

19 Aug 2021

Study identifies gene families responsible for simple leaf development

Recent research elucidates how simple leaves—one of the two basic forms of leaves—originate in a plant.

18 Aug 2021

New technique can map out nearly all of the regulatory switches across a maize genome

Getting a full understanding of how genes are regulated is a major goal of scientists worldwide. Now, a Florida State University professor and his research partners have developed a technique that can map out nearly all of the likely regulatory switches across a genome.

16 Aug 2021

Researchers identify virus-derived variations in human genomes

Three geneticists from RIKEN identified previously undetected snippets of genetic material from viruses that were hidden in human DNA.

12 Aug 2021

Research provides a detailed 'proteogenomic' view of lung squamous cell carcinoma

Lung cancer remains the leading cause of cancer-associated death in the United States and worldwide. Patients with a subtype called lung adenocarcinoma (LUAD) have benefited from the development of new targeted medicines, but the search for effective new therapies for another subtype called lung squamous cell carcinoma (LSCC) has largely come up short.

6 Aug 2021

Transcription News and Research

Supercoiling and looping can transmit mechanical stress along the DNA backbone, shows study

Study employs machine learning to predict outcomes in agriculture

Scientists analyze the molecular machinery of poxviruses at an atomic level

How does the KLF4 transcription factor influence gene expression?

Genetic and epigenetic origin of pediatric liver cancer uncovered

Researchers seek to point a way toward a unified theory for DNA folding

Study reveals how the tumor suppressor gene plays a vital role in pediatric rhabdomyosarcoma

Researchers develop novel cell reprogramming strategy to slow down glioblastomas

Study uncovers mechanism where two transcription factors stabilize each other’s binding to DNA

Researchers develop a new method for monitoring organic pollutants using plants

Viruses buried in marsupials' DNA may help protect against future infections

Study imparts mechanistic understanding on early stages of human cancer

Study unearths previously unknown role of CTCF, the transcription regulator

Study details how immature innate lymphoid cells become effector cells

Study identifies variants and genes linked to alcohol consumption

Genomic surveillance is vital to achieve effective mitigation and containment of COVID-19

Study identifies gene families responsible for simple leaf development

New technique can map out nearly all of the regulatory switches across a maize genome

Researchers identify virus-derived variations in human genomes

Research provides a detailed 'proteogenomic' view of lung squamous cell carcinoma

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