Liberty Blue™ Automated Microwave Peptide Synthesizer

The Liberty Blue™ Automated Microwave Peptide Synthesize from CEM is the most popular peptide synthesizer worldwide. It has a 4-minute cycle time and reduces solvent by 90% based on High-Efficiency Solid Phase Peptide synthesis (HE-SPPS) designed in 2013.

The Liberty Blue is utilized in scores of laboratories throughout the world and provides unprecedented peptide quality, thanks to its special methodology and use of microwaves. The Liberty Blue has new features in engineering for true internal temperature feedback control, software control with 21 CFR Part 11 compliance and fluidic deliveries.

Unique Chemistry

  • Microwave deprotection and coupling (patented)
  • CarboMAX™ coupling chemistry (patented)


  • Four-minute cycle time
  • Patented Flex-Add™ critical reagent delivery system
  • Reduces waste by 90% (HE-SPPS)
  • Optional built-in camera
  • True internal fiber-optic temperature control
  • High-throughput upgrade options
  • Scale range varies from 0.005 to 5 mmol
  • Includes 27 amino acid positions

An Incredibly Fast Peptide Synthesizer

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  • Four-minute cycle times (HE-SPPS)
  • Automated synthesis of up to 24 peptides (optional)
  • Access to peptides in less than one day

The Best Coupling Method for Peptide Synthesis

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  • Unparalleled low level of epimerization for all 20 amino acids
  • The quickest and most comprehensive coupling
  • Synthesis can be simplified by preventing the need for laborious method screening
  • Highest purities with patented microwave deprotection and coupling (US7393920, US7582728, US8058393 and CA2471687)

The Best Way to Deliver Critical Reagents

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  • No priming is required
  • Infinitely variable—provides user-defined volumes (unlike sample loops)
  • Less complicated than syringe pumps and does not require washing

Unprecedented 90% Solvent Reduction

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  • Prudent use of reagents and solvents from synthetic protocols and optimized washing
  • Excellent system design reduces cleaning, calibration and maintenance requirements

The Most Advanced Software for Simple and Flexible Control

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  • Automated programming of complex and standard peptides (cyclized, branched and disulfide bonding)
  • Built-in real-time camera into the microwave cavity
  • 21 CFR Part 11 compliance, including complete run history and method reports

The Standard is Raised for Peptide Purity

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The Liberty Blue allows unparalleled synthesis and quality of peptides. CEM’s systems use regulated microwave energy for the reaction to be heated and do not use the vessel.

Apart from the novel design of software, hardware and specialty chemicals, the company focuses on efficient systems for loading, monitoring, delivery and removal. This allows CEM to provide the improved chemistry for maximum yields and purity.

Synthesize Standard and Complex Peptides

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  • Cyclized peptides
  • Branched peptides
  • PNA
  • Disulfide bonding
  • Phospho-peptides
  • Glycopeptides (N/O-linked)
  • Peptide thioesters
  • N-Methyl peptides
  • High-throughput synthesis
  • Peptoids
Peptide Synthesizer - Liberty Blue Cycle Shown with Camera

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Webinar: Faster, More Efficient Peptide Synthesis

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Fast, Sequential Peptide Synthesis: Addressing the Synthesis and Purification Bottlenecks

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