CEM’s Liberty Prime Peptide Synthesizer is a state-of-the-art instrument developed for microwave peptide synthesis. Thanks to its novel one-pot deprotection and coupling process, the Liberty Prime Peptide Synthesizer achieves an incredible 2-minute cycle time with just 8.5 mL waste per cycle (at 0.1 mmol).
Unique Chemistry
- Microwave deprotection and coupling (patented)
- One-pot coupling and deprotection chemistry (patented)
- CarboMAX™ coupling chemistry (patented)
Features
- Unprecedented 2-minute cycle time
- Optional Combined Camera
- Unparalleled 8.5 mL waste per cycle at (0.1 mmol)
- Accurate calibration-free delivery of all reagents
- Automated synthesis of up to 24 peptides
Synthesize 20mer’sEvery 45 Minutes
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A revolutionary 2-minute cycle time is achieved, thanks to the patented CarboMAX coupling chemistry and a novel one-pot deprotection and coupling process.
Reduce SPPS Chemical Waste to Unbelievable Levels
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The Liberty Prime Peptide Synthesizer uses a patented process to reuse the coupling solution for the successive deprotection step. Besides this, the system has been developed in such a way that it eliminates internal washing. This considerably decreases the production of waste.
No Calibration is Needed
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The reagents can be supplied either by a pre-calibrated pumping system or a pressure-based Flex-Add delivery system. Thus, the right amount of each reagent is provided every time down to volumes as low as 0.25 mL. The calibration-free reagent delivery is ideal for GMP processes.
The Best Coupling Method for Peptide Synthesis
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- The quickest and most comprehensive coupling
- Unparalleled low-level of epimerization for all 20 amino acids because of quicker activation (faster o-acylisourea formation)
- Stabilizes acid-sensitive linkages that are challenging for standard carbodiimide chemistry (glyco, phospho and hyper-acid linkages)
Synthesize Standard and Complex Peptides
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- Cyclized peptides
- Branched peptides
- Disulfide bonding
- High-throughput synthesis
- Glycopeptides (N/O-linked)
- Phosphopeptides
- PNA
- N-methyl peptides
- Peptoids
- Peptide thioesters
Cleave Batches of Peptides in Only 30 Minutes
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For the Liberty Prime Peptide Synthesizer, the Razor is the ideal companion. It takes only 30 minutes to cleave peptides while safeguarding the synthesizer from volatile TFA fumes.