Liberty Prime Peptide Synthesizer

CEM’s Liberty Prime Peptide Synthesizer is a state-of-the-art instrument developed for microwave peptide synthesis. Thanks to its novel one-pot deprotection and coupling process, the Liberty Prime Peptide Synthesizer achieves an incredible 2-minute cycle time with just 8.5 mL waste per cycle (at 0.1 mmol).

Unique Chemistry

  • Microwave deprotection and coupling (patented)
  • One-pot coupling and deprotection chemistry (patented)
  • CarboMAX™ coupling chemistry (patented)

Features

  • Unprecedented 2-minute cycle time
  • Optional Combined Camera
  • Unparalleled 8.5 mL waste per cycle at (0.1 mmol)
  • Accurate calibration-free delivery of all reagents
  • Automated synthesis of up to 24 peptides

Synthesize 20mer’sEvery 45 Minutes

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A revolutionary 2-minute cycle time is achieved, thanks to the patented CarboMAX coupling chemistry and a novel one-pot deprotection and coupling process.

Reduce SPPS Chemical Waste to Unbelievable Levels

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The Liberty Prime Peptide Synthesizer uses a patented process to reuse the coupling solution for the successive deprotection step. Besides this, the system has been developed in such a way that it eliminates internal washing. This considerably decreases the production of waste.

No Calibration is Needed

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The reagents can be supplied either by a pre-calibrated pumping system or a pressure-based Flex-Add delivery system. Thus, the right amount of each reagent is provided every time down to volumes as low as 0.25 mL. The calibration-free reagent delivery is ideal for GMP processes.

The Best Coupling Method for Peptide Synthesis

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  • The quickest and most comprehensive coupling
  • Unparalleled low-level of epimerization for all 20 amino acids because of quicker activation (faster o-acylisourea formation)
  • Stabilizes acid-sensitive linkages that are challenging for standard carbodiimide chemistry (glyco, phospho and hyper-acid linkages)

Synthesize Standard and Complex Peptides

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  • Cyclized peptides
  • Branched peptides
  • Disulfide bonding
  • High-throughput synthesis
  • Glycopeptides (N/O-linked)
  • Phosphopeptides
  • PNA
  • N-methyl peptides
  • Peptoids
  • Peptide thioesters

Cleave Batches of Peptides in Only 30 Minutes

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For the Liberty Prime Peptide Synthesizer, the Razor is the ideal companion. It takes only 30 minutes to cleave peptides while safeguarding the synthesizer from volatile TFA fumes.