MultiPep 1™: The Highly Flexible Automated Parallel Peptide Synthesizer

MultiPep 1™ from CEM is a highly flexible and affordable automated parallel peptide synthesizer. Using plates, columns, or cellulose membrane formats, the MultiPep 1™ has unprecedented flexibility for screening an infinite number of peptides simultaneously.

Flexible Formats

  • Plate: Up to 96 peptides ranging from 1 to 10 μmol
  • CelluSpots™: Up to 768 peptides are provided on a dissolvable cellulose support
  • SPOT synthesis: Up to 1200 peptides are available on a couple of cellulose membranes support
  • Columns: Up to 8 peptides ranging from 1 to 10 μmol or 48 peptides ranging from 10 to 300 μmol


  • In-situ activation or pre-activation
  • Has a heating option for high-temperature synthesis in plates and columns
  • Enables vortex mixing
  • Allows quick synthesis through an eight-position parallel washing arm

Peptide Libraries

Peptide Synthesis with 96-Well Plates and Columns

With the help of MultiPep 1™, large libraries of peptides can be easily produced through a 96-well plate. Uses can also use mini-columns to generate up to 48 peptides concurrently. In total, eight bigger columns (2, 5, or 10 mL size) can be utilized simultaneously.

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Integrated Heating Module

Parallel Peptide Synthesis at Elevated Temperatures

High-temperature synthesis conditions can be applied to either 96 plates or well columns run on the MultiPep 1™. This procedure has been made easy, thanks to optional heating block accessories fitted with adjustable temperature control. High temperatures are handy for improving the purity of complex and lengthier sequences.

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SPOT Synthesis

Peptide Microarrays

SPOT synthesis makes it possible to create an infinite number of immobilized peptides on cellulose membranes. This is useful for cell-based and solution-based assays as well as on-support binding studies. The MultiPep 1™ has a SPOT synthesis option that allows users to generate up to 1200 peptides in just one batch for high-throughput screening applications.

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Multiple Copies of Peptide Arrays on Glass Slides

Users can now effortlessly create many copies of a peptide array on glass slides. The CelluSpots technology combines the advantages of traditional SPOT synthesis with special dissolvable cellulose support for making many identical copies of a peptide array. This depends on the use of the unique Slide Spotting robot after SPOT synthesis on the dissolvable cellulose support.

Image Credit: CEM Corporation - Life Science

Peptide Nucleic Acids

Optimized PNA Synthesis

The MultiPep 1™ is a powerful tool designed for small-scale synthesis where there is a need for useful monomers, such as PNA. Due to the small fluid delivery capabilities of the MultiPep 1™, users can perform PNA synthesis down to 1 μmol. In total, up to 48 smaller columns (250 and 500 μL sizes) can be utilized simultaneously.

Image Credit: CEM Corporation - Life Science