Identifying targets for development of COVID-19 drugs & vaccines

AMSBIO has extended its COVID-19 research portfolio with the introduction of a service to provide custom lentivirus pseudotyped with spike glycoprotein from SARS-CoV-2 to help researchers identify potential targets for development of therapeutic drugs and vaccines.

Identifying targets for development of COVID-19 drugs & vaccines

Various research groups around the world have demonstrated that SARS-CoV-2 uses its spike glycoprotein S, a main target for neutralization antibody, to bind its receptor, and mediate membrane fusion and virus entry.

In response to widespread demand, AMSBIO has developed a custom service to provide ready-to-use in vitro and in vivo grade lentiviral particles pseudotyped with coronavirus S protein. Pseudotyping of lentivirus is available with wild type or mutant S proteins from a wide range of coronavirus species. In addition, AMSBIO can offer wide ranging customization options including addition of reporter genes for monitoring viral entry. This complete range of products are safe to be used in BSL-2 labs.

The AMSBIO lentiviral system is a novel gene delivery tool using lentivectors for gene expression or knockdown. Lentivirus can effectively transduce both dividing and non-dividing mammalian cells, and integrate into the host genome, allowing stable long-term, high-level gene expression both in vivo and in vitro. Unlike traditional retroviral system, AMSBIO lentivirus is much more actively imported into the nuclei of non-dividing cells and stably integrated into the host cell's genome independent of cell cycle.

Citations

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    AMS Biotechnology. (2020, May 07). Identifying targets for development of COVID-19 drugs & vaccines. AZoLifeSciences. Retrieved on November 25, 2020 from https://www.azolifesciences.com/news/20200507/Identifying-targets-for-development-of-COVID-19-drugs-vaccines.aspx.

  • MLA

    AMS Biotechnology. "Identifying targets for development of COVID-19 drugs & vaccines". AZoLifeSciences. 25 November 2020. <https://www.azolifesciences.com/news/20200507/Identifying-targets-for-development-of-COVID-19-drugs-vaccines.aspx>.

  • Chicago

    AMS Biotechnology. "Identifying targets for development of COVID-19 drugs & vaccines". AZoLifeSciences. https://www.azolifesciences.com/news/20200507/Identifying-targets-for-development-of-COVID-19-drugs-vaccines.aspx. (accessed November 25, 2020).

  • Harvard

    AMS Biotechnology. 2020. Identifying targets for development of COVID-19 drugs & vaccines. AZoLifeSciences, viewed 25 November 2020, https://www.azolifesciences.com/news/20200507/Identifying-targets-for-development-of-COVID-19-drugs-vaccines.aspx.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of AZoLifeSciences.
You might also like... ×
Total nucleic acid extraction for pathogen detection