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The latest analytical chemistry news from News-Medical |
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FTIR for GLP-1 Protein Structural Analysis
As demand for GLP-1 therapies accelerates globally, structural consistency is a critical quality challenge. This free infographic from Specac shows how FTIR spectroscopy delivers rapid, label-free insight into peptide integrity across solid and liquid formulations - helping R&D and QC teams detect aggregation early and generate audit-ready data
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| |  | | | This review shows how single-cell proteomics by mass spectrometry has advanced from an uncertain idea to a rapidly improving toolkit that can now quantify thousands of protein groups from individual cells. It argues that direct protein measurements, combined with better sample preparation, instrumentation, and multiplexing, could help researchers build more mechanistic models of cell biology while pushing throughput far higher. | | | | | This review examines how next-generation protein sequencing and analysis technologies are expanding proteomics beyond the limits of mass spectrometry, especially for detecting proteoforms and analyzing proteins at single-molecule resolution. It highlights maturing fluorescence-based and nanopore-based platforms that could complement existing methods and deepen insight into protein sequence, structure, function, and modification states. | | | | | Integrating proteomics with systems biology reveals complex cellular networks, improving disease mechanisms understanding and precision medicine applications. | | | | | Findings show microplastics in bile may trigger cellular senescence, suggesting a link to gallstone disease and highlighting the need for further research. | | | | | The study identifies pTOS as a key metabolite in appetite suppression, highlighting a gut–liver–brain pathway with implications for obesity therapy. | | | | | A 2026 case report describes a 34-year-old man with obesity and alcohol use disorder whose semaglutide treatment for weight loss was associated with a marked drop in drinking over 10 months, with his AUDIT score falling from 27 to 7 and alcohol use dropping from about 15 drinks per week to half a beer per month. | |
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