Immunology - Advanced Imaging Reveals Why Some Breast Cancers Resist Treatment
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    Advanced Imaging Reveals Why Some Breast Cancers Resist TreatmentAdvanced Imaging Reveals Why Some Breast Cancers Resist Treatment
 
The majority of breast cancer tumors are of the hormone receptor-positive subtype; however, not all patients benefit from standard tamoxifen therapy. A new study suggests that the loss of FRMD8 may explain tamoxifen resistance. The team used the TissueFAXS slide scanner to image biopsies and StrataQuest software to quantify the expression of ERα and PR in CK8+ epithelium.
 
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   Parasitic worm evades detection by suppressing skin neuronsParasitic worm evades detection by suppressing skin neurons
 
New research, published in The Journal of Immunology, discovered that a parasitic worm suppresses neurons in the skin to evade detection.
 
 Immune cells migrate from the gut to breast during pregnancy and lactation
 
Immune cells migrate from the gut to breast during pregnancy and lactationOf the 3.6 million babies born in the United States each year, around 80 percent begin breastfeeding in their first month of life.
 
 
 Genetically-engineered immune cells show promise for preventing organ rejection
 
Genetically-engineered immune cells show promise for preventing organ rejectionA Medical University of South Carolina team reports in Frontiers in Immunology that it has engineered a new type of genetically modified immune cell that can precisely target and neutralize antibody-producing cells complicit in organ rejection.
 
 
 New insights into pathogenic T cells offer hope for Crohn's disease treatment
 
New insights into pathogenic T cells offer hope for Crohn's disease treatmentThe research group led by Drs. Mitsuru Arase, Mari Murakami, and Prof. Kiyoshi Takeda (Graduate School of Medicine/ Immunology Frontier Research Center at The University of Osaka) revealed that transcription factors RUNX2 and BHLHE40 play crucial roles in inducing T cells involved in Crohn's disease.
 
 
 Lung tumors rewire immune cells in the bone marrow before they reach cancer sites
 
Lung tumors rewire immune cells in the bone marrow before they reach cancer sitesLung tumors don't just evade the immune system. They reshape it at its source. Researchers from the Icahn School of Medicine at Mount Sinai and collaborators report in the September 10 online issue of Nature that tumors rewire immune cells in the bone marrow before they even reach the cancer, suggesting a new target to enhance the durability of current immunotherapy
 
 
 Understanding immune drift in biologic therapy for inflammatory skin diseases
 
Understanding immune drift in biologic therapy for inflammatory skin diseasesImmune-inflammatory skin diseases (e.g., psoriasis, atopic dermatitis) involve dysregulation of CD4+ T-cell subsets (Th1/Th2/Th17/Treg) and cytokine networks (IL-17/IL-23/IL-4).
 
 

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