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The latest immunology news from News Medical |
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 Advanced Image Analysis Unlocks Immune Cell Interactions
Modern immunology relies on extracting meaningful, quantitative insights from complex 3D and 4D microscopy datasets. Imaris image analysis software enables researchers to visualise, segment and track immune cells within tissues and dynamic environments, supporting detailed analysis of cell–cell interactions, migration and functional responses. With AI assisted object detection, robust tracking tools and high performance 3D visualisation, Imaris helps immunologists turn large, multichannel datasets into reproducible results, accelerating discoveries across inflammation, infection and immune regulation research.
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|  | | | | |  How multi-omics is changing what scientists can see in the human immune system Human systems immunology is using multi-omics, single-cell tools, spatial technologies, and AI to decode immune responses across real-world human cohorts. The review highlights major opportunities for biomarker discovery and precision medicine, while stressing the need for rigorous study design, validation, and careful interpretation. | |  | | | | |  Single-cell sequencing reveals why some CAR-T therapies succeed while others fail Single-cell RNA sequencing is giving researchers a clearer view of why some CAR-T cells persist, expand, kill tumors effectively, or become exhausted. The review synthesizes 44 clinical scRNA-seq studies involving 500 patients and highlights how exhaustion, memory, cytotoxicity, clonal diversity, and metabolism may shape CAR-T responses. | |
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| | | |  A review of 1,801 registered CAR T clinical trials shows that multifunctional designs now account for 533 trials and 33% of new CAR T products submitted for clinical testing in 2025. The field is shifting toward multitargeted, safety-controlled, cytokine-secreting, and checkpoint-modulating CAR T cells, but manufacturing, regulation, and limited clinical outcome data remain key barriers. | | | | |  Short-term nutritional state can reshape T cell metabolism, with post-meal lipid metabolism enhancing T cell metabolic capacity, cytokine production, and persistence after activation. The study identifies triglyceride-rich chylomicrons as key drivers of this effect, suggesting nutritional timing may matter for immune monitoring, vaccination research, and cell-therapy manufacturing. | | | | |  CERTOMICS is a Nextflow-based computational pipeline designed to identify and profile CAR-engineered immune cells using single-cell multiomics data. By integrating gene expression, immune receptor profiling, protein markers, CAR-aware references, and CAR-specific quality control, it supports more standardized analysis of adoptive cellular immunotherapies. | | | | |  This review examines how the human microbiome regulates anti-tumor immunity through DNA damage, inflammation, immune-cell activity, microbial metabolites, and tumor microenvironment remodeling. It highlights emerging microbiome-based strategies, including FMT, probiotics, prebiotics, engineered bacteria, and live biotherapeutics, while stressing the need for rigorous validation and clinical trials. | | | | |  This review examines how CAR-T cell therapy is expanding beyond blood cancers into solid tumors, autoimmune diseases, chronic viral infections, and next-generation immune-cell platforms. It highlights promising engineering advances, including universal CAR-T cells, in vivo delivery, CAR-NK cells, and safety switches, while emphasizing unresolved challenges in durability, safety, scalability, and global access. | | | | |  New research shows Finnish sauna sessions rapidly mobilize immune cells, revealing heat stress effects on cytokines and potential health benefits. | |
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