Immunology - Antibody feedback reshapes B cell selection during immune response
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Overcoming Challenges in Inflammasome Drug DiscoveryOvercoming Challenges in Inflammasome Drug Discovery

As interest in NLRP3 and other inflammasome targets grows, drug developers face a critical challenge: demonstrating efficacy, selectivity, and safety early in the discovery pipeline. Explore recent breakthroughs in inflammasome biology, pitfalls that can derail even the most promising candidates, and how advanced models and tools are increasing predictability.

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   Antibody feedback reshapes B cell selection during immune responseAntibody feedback reshapes B cell selection during immune response
 
A collaborative study published in Immunity from the Batista Lab and Liu Lab at the Ragon Institute, together with the Schief Lab at Scripps Research Institute, has uncovered a previously unrecognized mechanism that shapes how immune cells are selected during an immune response.
 
   Study reveals cellular and metabolic landscape of lymph node metastasis in breast cancerStudy reveals cellular and metabolic landscape of lymph node metastasis in breast cancer
 
A recent integrative analysis of single-cell sequencing and single-cell spatial mapping of lymph node metastasis in breast cancer reveals novel mechanisms of the metabolic-immune interaction that drive the spread of breast cancer.
 
 Researchers validate Mpox antibody test during outbreak in Rwanda
 
Researchers validate Mpox antibody test during outbreak in RwandaAn antibody test for the infectious disease Mpox was successfully developed during the new clade 1b outbreak in Rwanda, the first time that an assay of its kind has been validated within this setting.
 
 
 How to analyze antibody aggregation and molecular weight using BeSEC
 
How to analyze antibody aggregation and molecular weight using BeSECLearn how BeSEC enables precise analysis of antibody aggregation and molecular weight through dual-angle light scattering.
 
 
 New Antibodies Prevent EBV Infection in Humanized Mouse Models
 
New Antibodies Prevent EBV Infection in Humanized Mouse ModelsFred Hutch Cancer Center scientists reached a crucial milestone in blocking Epstein Barr virus (EBV), a pathogen estimated to infect 95% of the global population that is linked to multiple types of cancer, neurodegenerative diseases and other chronic health conditions.
 
 
 New Insights Into Antibody Glycans may Advance Tuberculosis Prevention
 
New Insights Into Antibody Glycans may Advance Tuberculosis PreventionCertain antibodies inhibit Mycobacterium tuberculosis, the cause of tuberculosis (TB), the infectious disease that claims the most lives worldwide, a study led by UT Southwestern Medical Center researchers found.
 
 
 Research Shows Successful Recovery of Antigen-Specific T Cells in Mouse Models
 
Research Shows Successful Recovery of Antigen-Specific T Cells in Mouse ModelsResearchers at The Jackson Laboratory (JAX), in collaboration with the Massachusetts Institute of Technology (MIT), have developed the first bandage-like microneedle patch that can sample the body's immune responses painlessly from the skin. The device detects inflammatory signals within minutes and collects specialized immune cells within hours without the need for blood draws or surgical biopsies.
 
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