Drug Discovery - Machine learning advances drug discovery through generalizable models
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Cross-species liver-on-a-chip versus 2D performance comparison studyCross-species liver-on-a-chip versus 2D performance comparison study

How do liver-on-a-chip models stack up against traditional 2D cultures across species? Naga et al. (2025) highlight PhysioMimix® technology as “a sensible model for longer-term in vitro studies, particularly in cases where hepatotoxicity may arise through complex or delayed mechanisms.”

Explore the PhysioMimix® Difference
 
   Machine learning advances drug discovery through generalizable modelsMachine learning advances drug discovery through generalizable models
 
The drug development pipeline is a costly and lengthy process. Identifying high-quality "hit" compounds-those with high potency, selectivity, and favorable metabolic properties-at the earliest stages is important for reducing cost and accelerating the path to clinical trials.
 
   AI indelibly transforms solid tumor drug developmentAI indelibly transforms solid tumor drug development
 
Artificial intelligence (AI) is fundamentally reshaping the landscape of solid tumor (ST) drug development.
 
 Cyclana Bio raises £5M to advance drug discovery for endometriosis
 
Cyclana Bio raises £5M to advance drug discovery for endometriosisCyclana Bio, a biotechnology company pioneering tissue-level approaches to women's health, today announced the close of a £5M pre-seed funding round, co-led by NfX and Eka VC, and including Cocoa VC, Wilbe, and Angel investors.
 
 
 AI predicts cell responses to drugs and genetic changes
 
AI predicts cell responses to drugs and genetic changesControlling the state of a cell in a desired direction is one of the central challenges in life sciences, including drug development, cancer treatment, and regenerative medicine.
 
 
 Landmark trial shows drug-eluting balloon as effective option for in-stent restenosis
 
Landmark trial shows drug-eluting balloon as effective option for in-stent restenosisResults from the first randomized clinical trial in the United States to compare a sirolimus-eluting balloon (DEB) to control group consisting of drug-eluting stent (DES) and balloon angioplasty (BA) for the treatment of bare-metal and DES in-stent restenosis (ISR) deemed DEB to be noninferior to conventional therapies.
 
 
 Belzutifan demonstrates strong clinical activity in two rare neuroendocrine tumors
 
Belzutifan demonstrates strong clinical activity in two rare neuroendocrine tumorsA multicenter Phase II clinical trial led by researchers at The University of Texas MD Anderson Cancer Center demonstrated significant tumor shrinkage and disease control in patients with advanced pheochromocytoma and paraganglioma (PPGL), two rare and potentially life-threatening neuroendocrine tumors.
 
 
 Largest trial of adjuvant pembrolizumab in Merkel cell carcinoma reports key benefit
 
Largest trial of adjuvant pembrolizumab in Merkel cell carcinoma reports key benefitA new cancer clinical trial by the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) shows that a drug that utilizes the body's immune system to target and eliminate cancer cells appeared to reduce the risk of distant metastases for an aggressive form of skin cancer when given immediately after surgery, but did not significantly reduce the overall risk of recurrence, which was a co-primary endpoint of the trial.
 
 
 Economic growth drives disparities in global cancer research
 
Economic growth drives disparities in global cancer researchNew research reveals that the number and complexity of cancer clinical trials since 2001 have varied across low- and middle-income countries (LMICs), with economic growth contributing to disparities, but only to a certain extent. The findings are published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society.
 
 

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