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Researchers Identify Genes Linked to Genomic Instability and DNA Damage

More than one hundred key genes linked to DNA damage have been uncovered through systematic screening of nearly 1,000 genetically modified mouse lines, in a new study published today (14 February) in Nature.

16 Feb 2024

Unraveling Lenacapavir's Impact on the HIV Life Cycle

A new anti-retroviral medication for the treatment of human immunodeficiency virus (HIV) infections was licensed by the US Food and Drug Administration and the European Union just over a year ago.

14 Feb 2024

New Research Sheds Light on Divergent Roles of Paralogous RNA Helicases

Genetic expression, often leading to protein synthesis, requires a complex coordination of molecular machinery across several stages.

9 Feb 2024

Scientists Reveal HIV's Secret Weapon for Invading Cell Nucleus

Around one million individuals worldwide become infected with HIV, the virus that causes AIDS, each year.

27 Jan 2024

New Technique Reveals Order and Flow in the Cell's Control Center

Though its material characteristics still baffle scientists, the cell nucleus is thought to be the center of control for essential cellular functions

22 Jan 2024

Cracking the Code of the Cytoplasm: How Cells Organize Protein Production

Back in 2018, the lab of Christine Mayr, MD, PhD, at Memorial Sloan Kettering Cancer Center (MSK) introduced the world to a key cellular component that had been hiding in plain sight.

22 Dec 2023

How 3D DNA Architecture Shapes Cell Fate in Early Embryos

The intricate process of duplicating genetic information, referred to as DNA replication, lies at the heart of the transmission of life from one cell to another and from one organism to the next. This happens by not just simply copying the genetic information; a well-orchestrated sequence of molecular events has to happen at the right time.

21 Dec 2023

Non-Invasive Early Cancer Detection Using Chromatin Signatures in Mononuclear Blood Cells

Blood cells reveal tumors in the body. Researchers at the Paul Scherrer Institute achieve an advance with the development of a test for early diagnosis of cancer.

18 Dec 2023

Unraveling the Complexities of Gene Regulation with MAbID

A novel technique named MAbID, developed by researchers led by Jop Kind, has been introduced to concurrently investigate various mechanisms of gene regulation, crucial for both development and disease processes.

5 Dec 2023

Misfolded Proteins: How They Damage Neurons and Cause Neurodegeneration

Neurodegenerative diseases are characterized by the deposition of clumped proteins in the brain and progressive neuronal cell death.

5 Dec 2023

New Model Reveals How Cells Maintain Epigenetic Memory During Cell Division

Every cell in the human body contains the same genetic instructions, encoded in its DNA. However, out of about 30,000 genes, each cell expresses only those genes that it needs to become a nerve cell, immune cell, or any of the other hundreds of cell types in the body.

17 Nov 2023

Study Discovers Fanzors in Eukaryotic Organisms

Snails, algae, and amoebas all have programmable DNA-cutting enzymes called Fanzors, and a recent study from Massachusetts Institute of Technology’s (MIT) McGovern Institute for Brain Research has found hundreds of them.

16 Oct 2023

Study Delves Deeper into Understanding How Humans Behave

Throughout a person’s life, many stimuli can turn on and off many of the genes, resulting in the variances that distinguish people.

20 Sep 2023

Changes in RNA Induced by Different Chemical Modifications

RNA is essential for protein synthesis in the cell. According to a new study, RNA can be modified by numerous chemical modifications, the purpose of which is unknown to most people.

28 Aug 2023

New Mechanism to Maintain Astrocyte-Neuron Communication

Neurons and astrocytes are the two types of cells required by the brain to enjoy the scent of morning coffee and freshly baked cookies or to discern the warning smell of something burning.

16 Jun 2023

Study Advances Understanding of the Deep Evolutionary History of Viruses

Researchers have proposed a new evolutionary model for the origin of a kingdom of viruses called Bamfordvirae, suggesting a billion-years evolutionary arms race between two groups within this kingdom and their hosts.

3 May 2023

Study Reveals That Transcriptional Buffering Occurs in Rett Syndrome Nerve Cells

Every cell in our body is able to turn genes (DNA) on or off, producing RNA, but when genes are 'turned on' to the wrong level it can result in a variety of health conditions.

3 May 2023

Understanding the Process of Gene Regulation Using Cryogenic Electron Microscopy

LMU researchers show detailed displacement process of TBP transcription factor from DNA by Mot1 enzyme.

2 May 2023

Research Deepens Our Understanding of Circadian Rhythm Regulation

New research from a multidisciplinary team helps to illuminate the mechanisms behind circadian rhythms, offering new hope for dealing with jet lag, insomnia and other sleep disorders.

27 Apr 2023

Membrane-Remodeling Proteins in Cyanobacteria are Similar to Protein Found in Higher Organisms

The cells of living organisms are equipped with proteins that are involved in the shaping and remodeling of cellular membranes, thereby performing important tasks.

26 Apr 2023