Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Epigenomic Analysis Reveals Potential Treatment Avenues for ALS

For most patients, it's unknown exactly what causes amyotrophic lateral sclerosis (ALS), a disease characterized by degeneration of motor neurons that impairs muscle control and eventually leads to death.

3 May 2024

Mapping Small Molecule-Protein Interactions for Drug Development

For most human proteins, there are no small molecules known to bind them chemically (so called "ligands"). Ligands frequently represent important starting points for drug development but this knowledge gap critically hampers the development of novel medicines.

30 Apr 2024

Enhancing Drug Discovery Through Automated Protein Labeling

Exact protein observation in cells is crucial for many scientific fields, but it has proven to be a difficult technical task, particularly in living cells where each protein needs to have its fluorescent label applied separately.

22 Apr 2024

Unveiling Cannabinoid’s Potential for Treating Age-Related Brain Degeneration

Scientists at the Salk Institute observed the neuroprotective effects of cannabinol in fruit flies and discovered cannabinoid analogs that may prove to be promising future treatments for Parkinson's, Alzheimer's, and traumatic brain injury.

18 Apr 2024

Unlocking Bacterial Dormancy: Polyphosphates' Role Revealed

Most disease-causing bacteria are known for their speed: In mere minutes, they can double their population, quickly making a person sick.

12 Apr 2024

Designing Compounds for Next-Gen Antibiotics and Cancer Treatments

Chemists at Cold Spring Harbor Laboratory (CSHL) have generated a novel set of molecular compounds and are evaluating them as possible candidates for novel drug discovery leads.

5 Apr 2024

Study Reveals Structure of Two Nucleic Acid-Degrading Enzymes

When nucleic acids like DNA or RNA build up in a cell's cytoplasm, it sets off an alarm call for the immune system.

3 Apr 2024

Unveiling the Potential of the New Antibiotics Against Bacteria

A novel family of antibiotics with strong action against bacteria resistant to many drugs has been found by Uppsala University researchers, and they have demonstrated that this class of antibiotics may treat bloodstream infections in mice.

2 Apr 2024

Groundbreaking AI Framework Revolutionizes Drug Discovery

A transformative study published in Health Data Science, a Science Partner Journal, introduces a groundbreaking end-to-end deep learning framework, known as Knowledge-Empowered Drug Discovery, aimed at revolutionizing the field of drug discovery.

1 Apr 2024

Federal Regulation Urged for Direct-to-Consumer Microbiome Tests

Scientific research has linked a person's microbiome to everything from gut and mental health to immunity and predisposition to cancer.

25 Mar 2024

Nature-Inspired Approach Accelerates Folding of Cysteine-Rich Peptides for Drug Discovery

Certain types of peptides and microproteins for drug discovery research can be made more efficiently and quickly using a reaction solvent that helps mimic nature's way.

25 Mar 2024

U of T Researchers Develop Groundbreaking Platform for Protein-Based Disease Treatment

Researchers at the University of Toronto and Sinai Health have created a new platform to identify proteins that can be co-opted to control the stability of other proteins -; a new but largely unrealized approach to the treatment of disease.

25 Mar 2024

UT Southwestern Unveils New Method for Fighting Complex Infections

Treating complex bacterial infections with customized therapies tailored to the infection and the patient is closer to reality, thanks to researchers at UT Southwestern Medical Center.

22 Mar 2024

Metrion Biosciences Strengthens Team with Three Key Appointments

Metrion Biosciences Limited (“Metrion”), the specialist ion channel contract research organisation (CRO) and drug discovery company, has promoted Clare Rutty to CFO and welcomes two new hires in Sue Peffer as Head of Marketing and Leanne Clarke as HR Officer.

12 Mar 2024

Breakthrough Studies Shed Light on Origins of Homochirality in Biology

Molecules often have a structural asymmetry called chirality, which means they can appear in alternative, mirror-image versions, akin to the left and right versions of human hands.

29 Feb 2024

New "Tissue-in-a-CUBE" Offers Alternative to Animal Testing in Drug Development

A research team at the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan has succeeded in establishing a model of the blood-brain barrier using modularized tissue derived from human cells.

29 Feb 2024

AI's Impact on Protein Function Prediction Revealed

Researchers may be able to learn more about the inner workings of cells with the aid of a novel artificial intelligence (AI) technology that makes logical deductions regarding the function of unidentified proteins.

15 Feb 2024

Dr. Bartek Rajwa of Purdue University Named Editor-in-Chief of “Cytometry Part A” Journal by the International Society for Advancement of Cytometry

The International Society for Advancement of Cytometry (ISAC) is pleased to announce the appointment of Dr. Bartek Rajwa as the new Editor-in-Chief of “Cytometry Part A – the Journal of Quantitative Cell Science.”

10 Feb 2024

Aspen Biosciences Launches Pipeline, The Program Management Software Platform Specifically for Drug Discovery. The Groundbreaking ‘Pipeline’ Platform is Now Available for Therapeutics Development Teams

Aspen Biosciences, a leading provider of custom software, and integrations for drug discovery companies, is excited to announce the launch of Pipeline, the drug discovery program management software platform.

8 Feb 2024

ELRIG UK Announces Steve Bates and Dr Anderson Ryan as Keynote Speakers at Research and Innovation 2024

The European Laboratory Research & Innovation Group (ELRIG) UK today announced the keynote speakers for its upcoming Research and Innovation conference taking place at the University of Manchester from 20–21 March.

From ELRIG (UK) Ltd. 8 Feb 2024