Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Scientists Discover Specific Genes Involved in Rare, Life-Threatening Heart Disease

By identifying genes in patients and testing their effects in fruit flies, researchers from Sanford Burnham Prebys have found new genes that contribute to hypoplastic left heart syndrome (HLHS), a rare, life-threatening heart disease that occurs in infants.

18 Jul 2023

Next Step in Sartorius Partnership Finalized: Several Subsales and Distribution Agreements as Well as R&D Project Agreements Have Been Signed

During May and June 2023 several sub-sales and distribution agreements were signed between Sartorius and BICO companies CELLINK, Advanced BioMatrix (ABM) and Dispendix.

From BICO 5 Jul 2023

Deep Learning Model Accurately Predicts RNA-Targeting CRISPR Activity

According to new research published in Nature Biotechnology, artificial intelligence can predict on- and off-target behavior of CRISPR tools that target RNA rather than DNA.

5 Jul 2023

Camena Bioscience Closes $10m Series A Financing as Demand for DNA Synthesis Technology Increases

Camena Bioscience, a synthetic biology company providing genes to the pharmaceutical and biotechnology industries, today announced it has closed a $10m Series A financing round, led by Mercia.

4 Jul 2023

Theta Supercomputer Used To Find Essential Factors That Control Structural Change of HIV Protease

Every disease has a protein basis. For some diseases, like HIV, changes in protein structure are critical for how the virus infects a person's cells.

20 Jun 2023

Metrion Biosciences Appoints Dr Steve Jenkinson as VP, Drug Discovery and Safety Assessment to Strengthen US Operations

Metrion Biosciences Ltd (“Metrion”), the specialist ion channel contract research and drug discovery company, today announced the appointment of Dr Steve Jenkinson as Vice President, Drug Discovery and Safety Assessment.

12 Jun 2023

Research Uncovers the Biology Underpinning a Rare Genetic Mutation Linked to Painlessness

The biology underpinning a rare genetic mutation that allows its carrier to live virtually pain-free, heal more rapidly and experience reduced anxiety and fear, has been uncovered by new research from UCL.

24 May 2023

An In-Depth Analysis of the Human Genome Using the New “Pangenome”

The Human Genome Project, which began in April 2003, contributed to the revolutionization of biomedical research by giving researchers a reference map that allowed them to scan DNA sequences for genetic clues about the causes of a variety of diseases.

16 May 2023

New Method for Analyzing Protein Crystals Could Open Up Applications for Drug Discovery

A new method for analyzing protein crystals – developed by Cornell researchers and given a funky two-part name – could open up applications for new drug discovery and other areas of biotechnology and biochemistry.

12 May 2023

Using Mass-Spectrometry-Based Cancer Proteomics Datasets to Discover Potential Therapeutic Targets

A new research perspective was published in Oncotarget's Volume 14 on May 4, 2023, entitled, "Using cancer proteomics data to identify gene candidates for therapeutic targeting."

11 May 2023

Discovering Novel Senolytic Compounds with the Power of Artificial Intelligence

A new publication in the May issue of Nature Aging by researchers from Integrated Biosciences, a biotechnology company combining synthetic biology and machine learning to target aging, demonstrates the power of artificial intelligence (AI) to discover novel senolytic compounds, a class of small molecules under intense study for their ability to suppress age-related processes such as fibrosis, inflammation and cancer.

8 May 2023

Analyzing the Complex Sequence of Events Involved in Beta-Arrestin Interactions

Proteins that work like air traffic controllers, controlling the flow of signals in and out of human cells, have been examined in unparalleled detail for the first time using modern microscope techniques.

5 May 2023

Reducing Intracellular Ice Formation in Advanced Cell Models

Researchers at the University of Warwick have discovered a way for storing advanced cell models.

From The University of Warwick 3 May 2023

3D Genome Mapping may Lead to Targeted Therapeutic Options for Ependymoma

Researchers led by Sanford Burnham Prebys assistant professor Lukas Chavez, Ph.D., are leveraging the latest technology to take a never-before-seen look at ependymoma, one of the deadliest pediatric brain tumors.

28 Apr 2023

Mirror-Image Versions of a Small Molecule Pave New Way for Cancer Drug Discovery

Scripps Research scientists have developed a new strategy for identifying small molecules that can change the function of proteins, offering a promising path for discovering targeted drugs.

28 Apr 2023

High-Throughput Assay to Analyze the Effects of CAR-T Cells Using Image Cytometry

The April 2023 issue of SLAS Discovery contains six full-length articles and one mini-review covering high-throughput screening (HTS) for protease-inhibiting drugs, high-content phenotypic screening and other life sciences research.

28 Apr 2023

Increased Fucose Digestion by Gut Bacteria Linked to Lower Immune Responses to COVID-19 Vaccine

Gut bacteria that break down a sugar called fucose could be dampening our immune response to the COVID-19 mRNA vaccine, according to a study led by researchers from the Okinawa Institute of Science and Technology.

21 Apr 2023

Entry of Aging-Associated Enzymes into Human Genetic Material

An enzyme that controls aging and other metabolic processes accesses human genetic material to modify gene expression within the cell, according to a new study. Images of a sirtuin enzyme bound to a nucleosome, a tightly packed complex of DNA and proteins called histones, have been created by a team led by Penn State researchers.

17 Apr 2023

Study provides a feasible tool to evaluate vesicular endocytosis of NPC1L1-cargos and cholesterol absorption

Excessive cholesterol absorption from intestinal lumen contributes to the pathogenesis of hypercholesterolemia, which is a well-established risk factor for atherosclerotic cardiovascular disease.

29 Mar 2023

New inhibitor molecule disrupts the infection mechanism of SARS-CoV-2 coronavirus

A team of scientists led by the Department of Energy's Oak Ridge National Laboratory designed a molecule that disrupts the infection mechanism of the SARS-CoV-2 coronavirus and could be used to develop new treatments for COVID-19 and other viral diseases.

29 Mar 2023

Drug Discovery News and Research

Further Reading

Scientists Discover Specific Genes Involved in Rare, Life-Threatening Heart Disease

Next Step in Sartorius Partnership Finalized: Several Subsales and Distribution Agreements as Well as R&D Project Agreements Have Been Signed

Deep Learning Model Accurately Predicts RNA-Targeting CRISPR Activity

Camena Bioscience Closes $10m Series A Financing as Demand for DNA Synthesis Technology Increases

Theta Supercomputer Used To Find Essential Factors That Control Structural Change of HIV Protease

Metrion Biosciences Appoints Dr Steve Jenkinson as VP, Drug Discovery and Safety Assessment to Strengthen US Operations

Research Uncovers the Biology Underpinning a Rare Genetic Mutation Linked to Painlessness

An In-Depth Analysis of the Human Genome Using the New “Pangenome”

New Method for Analyzing Protein Crystals Could Open Up Applications for Drug Discovery

Using Mass-Spectrometry-Based Cancer Proteomics Datasets to Discover Potential Therapeutic Targets

Discovering Novel Senolytic Compounds with the Power of Artificial Intelligence

Analyzing the Complex Sequence of Events Involved in Beta-Arrestin Interactions

Reducing Intracellular Ice Formation in Advanced Cell Models

3D Genome Mapping may Lead to Targeted Therapeutic Options for Ependymoma

Mirror-Image Versions of a Small Molecule Pave New Way for Cancer Drug Discovery

High-Throughput Assay to Analyze the Effects of CAR-T Cells Using Image Cytometry

Increased Fucose Digestion by Gut Bacteria Linked to Lower Immune Responses to COVID-19 Vaccine

Entry of Aging-Associated Enzymes into Human Genetic Material

Study provides a feasible tool to evaluate vesicular endocytosis of NPC1L1-cargos and cholesterol absorption

New inhibitor molecule disrupts the infection mechanism of SARS-CoV-2 coronavirus

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