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Multidisciplinary approaches for data management in omics research

Bioinformatics, and by extension omic sciences - the collective disciplines that are dependent on the use of extensive datasets of biological information - present a challenge of data management for researchers all over the world.

25 Feb 2021

Enzyme in fruit fly larvae plays key role in waking up brain stem cells

Researchers studying an enzyme in fruit fly larvae have found that it plays an important role in waking up brain stem cells from their dormant 'quiescent' state, enabling them to proliferate and generate new neurons.

12 Feb 2021

Cell cycle of cancer cells can be disrupted using two commercially available inhibitors

With two commercially available inhibitors, the cell cycle of the cancer cells in the childhood tumor neuroblastoma can be disrupted at a key point causing tumor cell death.

12 Feb 2021

Researchers identify tumor suppressor gene involved in stress response

Even the larvae of the Drosophila fly contain adult progenitor cells. And these cells are the only ones that are preserved throughout the growth and are responsible for the development of adult tissues and organs.

11 Feb 2021

New method could help resolve unwanted genetic changes associated with CRISPR-Cas9 technique

A research team has used a novel method that could help resolve the issue of unnecessary genetic changes encountered in the CRISPR-Cas9 technique.

7 Dec 2020

Oncopig fulfills the unmet clinical modeling needs for hepatocellular carcinoma

Volume 11, Issue 28 of Oncotarget features "Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation" by Gaba et, al. which reported that reliable development of Oncopig HCC cell lines was demonstrated through hepatocyte isolation and Cre recombinase exposure across 15 Oncopigs.

12 Oct 2020

Scientists advance genetic understanding of the tree of life

The African baobab tree (Adansonia digitata) is called the tree of life. Baobab trees can live for more than a thousand years and provide food, livestock fodder, medicinal compounds, and raw materials. Baobab trees are incredibly significant. However, there are growing conservation concerns and until now, a lack of genetic information

From United States Department of Agriculture (USDA) 28 Aug 2020

Switching off 'master regulator' may offer neuroprotection from Parkinson's-related damage

Switching off a molecular "master regulator" may protect the brain from inflammatory damage and neurodegeneration in Parkinson's disease, reports a study published today in Nature Neuroscience.

18 Aug 2020

Genome analysis helps identify 568 cancer driver genes

Analysis of the genomes of 28,000 tumors from 66 types of cancer has led to the identification of 568 cancer driver gene.

18 Aug 2020

Existing drugs could disrupt SARS-CoV-2 from hijacking cells

An international team of researchers has analyzed how SARS-CoV-2, the virus that causes COVID-19, hijacks the proteins in its target cells.

30 Jun 2020

Researchers identify novel protein complex that regulates chromosome segregation

Researchers from the University of Tsukuba have identified a novel protein complex that regulates Aurora B localization to ensure that chromosomes are correctly separated during cell division.

26 Jun 2020

Super-resolution technology helps visualize DNA replication in single human cells

DNA replication is a process of critical importance to the cell, and must be coordinated precisely to ensure that genomic information is duplicated once and only once during each cell cycle.

26 Jun 2020

KAUST scientists reveal the genetic metronome within malaria parasites

The parasites responsible for malaria seem to march to their own beat.The mystery behind the molecular basis of how these parasites synch their rhythm in replication to the host's clock-driven rhythms has been solved.

10 Jun 2020

Salk researchers discover how cells remember their identity

Cancer is often the result of DNA mutations or problems with how cells divide, which can lead to cells "forgetting" what type of cell they are or how to function properly.

5 Jun 2020

Study demonstrates the role of p53 gene in cell cycle regulation and apoptosis

The p53 gene is crucial in cell biology and thus cell replacement therapy. The function of this gene is to control the cell cycle and stop tumor formation.

2 Jun 2020

Stem cell research may improve regenerative medicine

A new study has provided new insight into the mechanisms that cause mutations in pluripotent stem cells, offering potential ways for preventing mutations.

18 May 2020

Scientists find gene signature linked to worst prognosis in rare uterine cancer

Women who don't survive a rare and aggressive uterine cancer called uterine serous carcinoma, have high expression of a group of 73 genes, a score scientists say can help identify these women and improve their outcome.

22 Apr 2020

Study reveals new mechanism that controls chromosome inheritance

During the process of each single cell division, the chromosomal genetic data should be uniformly distributed between the freshly developing daughter cells.

13 Apr 2020

Study sheds light on the mechanism of cell division

There is no clear consensus on when exactly cells decide to divide. For four decades, the answer provided in the textbook was that this decision takes place in the initial phase of the existence of a cell—that is, soon after a mother cell divides into daughter cells.

7 Apr 2020