Microscopy

Microscopy is an umbrella term to describe techniques used to analyse small samples that cannot be viewed with the naked eye. There is a wide range of microscopy techniques and scientific instruments available that can be used depending on their applications. A microscope magnifies tiny objects or samples and can provide a wealth of vital information about their cell structure, contamination, parasites and so much more.

This hub will contain all of the information you need to know about microscopy and will include the latest news and fascinating research articles. Whether you are looking to expand your knowledge of compound microscopes or fluorescence microscopy, you will find it all here under featured articles and the latest interviews.

What is Microscopy?

The word microscope is derived from the Greek “mikros”, meaning small and, “skopein” meaning to see.

Deep Learning in Fluorescence Microscopy

‘Staining’ of Biological Samples when Using Electron Microscopy: Why stain density matters

Cryo-Electron Microscopy: An Overview

Applications of Scanning Electron Microscopy

Light Microscopy Techniques in Virology: An Overview

Uses of Microscopy in Forensics

What is FIB-SEM?

Investigating the Intersection between Microscopy and Healthcare

The Digital Evolution of Microscopy

Investigating the Applications of Meoscopy

Confocal Microscopy: An Overview

See more featured articles »

The Determination of Post-Mortem Interval (PMI) Using Transmission Electron Microscopy

Microscopy’s Involvement in Brain Imaging

What is Environmental Forensic Microscopy?

Using Microscopy for Deep In Vivo Brain Imaging

Visualizing the 3D Architecture of Tissues

Two-photon Microscopy Principles and Methodology

What is High-Resolution TEM (HR-TEM)?

Optical Microscopy: An Overview

Why Size Matters in Microscopy

Confocal Reflection Microscopy for Cell Migration Studies

Applications of 3D X-ray Microscopy

Scanning Helium Microscopy: An Overview

Using Electron Microscopy to Detect Viruses

Advances in Fluorescence Microscopy

Scanning Electron Microscopy (SEM): An Overview

Optimizing Live Cell Imaging with FRET Microscopy

Using Scanning Electron Microscopy to Image SARS-CoV-2

‘Staining’ of Biological Samples when Using Electron Microscopy: Why stain density matters

Microscopy in Oncology Research: Visualizing Tumor Microenvironments

Intravital Kidney Microscopy: An Overview

Applications of IVIS (In Vivo Imaging Systems)

Avoiding Cell Death in Fluorescence Microscopy

Imaging Nuclear Structures Using AFM

What is 3D X-Ray Microscopy?

What is Expansion Microscopy?

X-ray Microscopy: An Overview

Advances in Scanning Electron Microscopy

TEM Imaging Modes

Optimizing Live Cell Imaging with FRET Microscopy

Live-Cell Imaging with Super-Resolution Microscopy

Light Microscopy Techniques in Virology: An Overview

Transmission Electron Microscopy: An Overview

Identifying Corpses Using Microscopy

How Do Spectrometer Accessories Elevate Instrument Capabilities?

Electron Microscopy: An Overview

Applications of Polarized Light Microscopy

What are Polarized Light Microscopes and How Do They Work?

How do Epifluorescence Microscopes Work?

Microscopy and Artificial Intelligence

Advantages and Limitations of Fluorescence Microscopy

Understanding the Brain Through Electron Microscopy

Microscopy and Artificial Intelligence

Photobleaching in Fluorescence Microscopy

TEM Imaging Modes

Imaging Techniques in Drug Discovery

Role of Microscopy in Ballistics

Diagnosing Alzheimer's Using Microscopy

Microscopes in Forensic Epidemiology- An Overview

Expansion Microscopy in Neurology

Phase-Contrast Microscopy: An Overview

Fluorescence Microscopy: An Overview

What is Confocal Imaging?

Differentiating Tumors using Microscopy

Latest Microscopy News and Research

Built Oral Biofilm Models Reveal How Peri-Implantitis Develops

The study establishes in vitro biofilm models, revealing key insights into dysbiosis in peri-implantitis and paving the way for diagnostic advancements.

12 Sep 2025

Metastatic Lung Cancer Cells Cozy Up to Neurons and Form Synapses

Small cell lung cancer cells that metastasize to the brain cozy up to neurons and form working electrical connections, called synapses, according to an upcoming study led by Stanford Medicine researchers.

11 Sep 2025

Novel Fluorescent Reporter Technology Enables Real-Time Visualization of Apoptosis Inside Cells

Cells in our body are programmed to die after a certain period of time-a natural process known as apoptosis or "cell suicide."

4 Sep 2025

Human-Derived 3D Skin Model May Replace Animals In Wound Studies

Engineered 3D skin model successfully simulates early wound healing, offering insights into inflammatory responses and potential therapeutic applications.

3 Sep 2025

Fruit Fly Study Highlights Benefits of Heterogeneity Among Cells

All living beings, big or small, are formed through the hard work of many different cells. To keep the body ready for any challenge, cells need to be dynamic.

29 Aug 2025

Molecular Blueprint Reveals Structure and Delivery of Botulinum Toxin

Researchers at Stockholm University have succeeded in creating a molecular blueprint of how one of the world's most dangerous toxins, botulinum toxin, is structured, stabilized, delivered and released.

28 Aug 2025

Ultrack Enables Fast and Accurate Cell Tracking in 3D Embryo Imaging

With today's advanced microscopes, scientists can capture videos of entire embryos developing in real time.

27 Aug 2025

How Bacillus Spores Initiate Self-Healing Concrete

Findings on Bacillus pasteurii spore germination and impermeability mechanisms offer insights into developing effective microbial self-healing concrete systems.

27 Aug 2025

Cryo-Optical Microscopy Captures Instantaneous Snapshots of Cellular Waves

Optical microscopy is a key technique for understanding dynamic biological processes in cells, but observing these high-speed cellular dynamics accurately, at high spatial resolution, has long been a formidable task.

25 Aug 2025

Comprehensive Guide Sets New Standards for Plant Fluorescence Imaging

A team of expert scientists led by Kirk Czymmek, PhD, director of the Advanced Bioimaging Laboratory at the Donald Danforth Plant Science Center and Heather E. McFarlane, assistant professor at the University of Toronto and collaborators from the Danforth Center, University of Leeds (UK), University of Massachusetts (Amherst), University of California - Davis, University of Naples Federico II, University of Minnesota and Université de Montréal, have authored a comprehensive guide to elevate the quality, transparency, and reproducibility of fluorescence microscopy in plant research. The guide was recently published in the journal Plant Cell, "Best Practices in Plant Fluorescence Imaging and Reporting: A Primer"

22 Aug 2025

Atomic Force Microscopy and AI Transform Understanding of Tangled DNA

At school, it's often presented as a tidy double helix but scientists are revealing the varied and intricate shapes of DNA molecules.

22 Aug 2025

Feline Dementia May Explain Synapse Loss in Alzheimers

The study uncovers amyloid-beta's role in glial-mediated synapse loss in feline cognitive dysfunction, enhancing understanding of Alzheimer's disease.

20 Aug 2025

EVIDENT to Acquire Pramana, Inc.

Evident announces a definitive agreement to acquire Pramana, Inc., a leading manufacturer of digital pathology solutions.

From EVIDENT 14 Aug 2025

New Water-Based Method Extracts High-Purity Lignin

The Nanoscience Center at the University of Jyväskylä discovered that lignin, a polyphenol vital for plant structure, has an antimicrobial effect against viruses and bacteria.

13 Aug 2025

New Imaging System Reveals Cellular Activity at Unprecedented Depths

Both for research and medical purposes, researchers have spent decades pushing the limits of microscopy to produce ever deeper and sharper images of brain activity, not only in the cortex but also in regions underneath such as the hippocampus.

8 Aug 2025

Parkinson’s Gene Mutation Blocks Vital Neuroprotective Signals

GBA1 mutations impair ciliary Hedgehog signaling in Parkinson's disease, reducing neuroprotective factors and highlighting a shared pathogenic pathway.

7 Aug 2025

New Atomic Force Microscopy Reveals Biofilm Architecture

Scientists at the Department of Energy's Oak Ridge National Laboratory have reimagined the capabilities of atomic force microscopy, or AFM, transforming it from a tool for imaging nanoscale features into one that also captures large-scale biological architecture.

6 Aug 2025