Microscopy

Microscopy is an umbrella term to describe techniques used to analyse small samples that cannot be viewed with the naked eye. There is a wide range of microscopy techniques and scientific instruments available that can be used depending on their applications. A microscope magnifies tiny objects or samples and can provide a wealth of vital information about their cell structure, contamination, parasites and so much more.

This hub will contain all of the information you need to know about microscopy and will include the latest news and fascinating research articles. Whether you are looking to expand your knowledge of compound microscopes or fluorescence microscopy, you will find it all here under featured articles and the latest interviews.

What is Microscopy?

The word microscope is derived from the Greek “mikros”, meaning small and, “skopein” meaning to see.

Optimizing Live Cell Imaging with FRET Microscopy

What is Expansion Microscopy?

What is Environmental Forensic Microscopy?

Live-Cell Imaging with Super-Resolution Microscopy

Phase-Contrast Microscopy: An Overview

What is Confocal Imaging?

Deep Learning in Fluorescence Microscopy

Advances in Fluorescence Microscopy

TEM Imaging Modes

What is High-Resolution TEM (HR-TEM)?

Microscopes in Forensic Epidemiology- An Overview

See more featured articles »

Applications of Scanning Electron Microscopy

Imaging Nuclear Structures Using AFM

How Do Spectrometer Accessories Elevate Instrument Capabilities?

What is FIB-SEM?

Applications of Polarized Light Microscopy

‘Staining’ of Biological Samples when Using Electron Microscopy: Why stain density matters

Applications of IVIS (In Vivo Imaging Systems)

Differentiating Tumors using Microscopy

What is 3D X-Ray Microscopy?

Intravital Kidney Microscopy: An Overview

Microscopy and Artificial Intelligence

Investigating the Intersection between Microscopy and Healthcare

Expansion Microscopy in Neurology

Diagnosing Alzheimer's Using Microscopy

Scanning Helium Microscopy: An Overview

Two-photon Microscopy Principles and Methodology

Optical Microscopy: An Overview

Why Size Matters in Microscopy

Avoiding Cell Death in Fluorescence Microscopy

Investigating the Applications of Meoscopy

Using Electron Microscopy to Detect Viruses

Light Microscopy Techniques in Virology: An Overview

Microscopy and Artificial Intelligence

Light Microscopy Techniques in Virology: An Overview

Advances in Scanning Electron Microscopy

Uses of Microscopy in Forensics

Microscopy in Oncology Research: Visualizing Tumor Microenvironments

Photobleaching in Fluorescence Microscopy

Confocal Reflection Microscopy for Cell Migration Studies

Confocal Microscopy: An Overview

The Determination of Post-Mortem Interval (PMI) Using Transmission Electron Microscopy

Optimizing Live Cell Imaging with FRET Microscopy

‘Staining’ of Biological Samples when Using Electron Microscopy: Why stain density matters

What are Polarized Light Microscopes and How Do They Work?

Using Scanning Electron Microscopy to Image SARS-CoV-2

TEM Imaging Modes

Scanning Electron Microscopy (SEM): An Overview

Fluorescence Microscopy: An Overview

Visualizing the 3D Architecture of Tissues

How do Epifluorescence Microscopes Work?

Cryo-Electron Microscopy: An Overview

Applications of 3D X-ray Microscopy

Electron Microscopy: An Overview

Transmission Electron Microscopy: An Overview

X-ray Microscopy: An Overview

Imaging Techniques in Drug Discovery

Microscopy’s Involvement in Brain Imaging

The Digital Evolution of Microscopy

Advantages and Limitations of Fluorescence Microscopy

Identifying Corpses Using Microscopy

Role of Microscopy in Ballistics

Using Microscopy for Deep In Vivo Brain Imaging

Understanding the Brain Through Electron Microscopy

Latest Microscopy News and Research

Understanding the Bacterial Propeller Architecture Offers Hope Against Antibiotic Resistance

Scientists have studied a new target for antibiotics in the greatest detail yet – in the fight against antibiotic resistance.

2 Jul 2025

ColdBrew Enhances Accuracy of Protein Water Mapping for Drug Design

Every protein in the body is encased in a water shell that directs protein structure, provides vital stability and steers function.

30 Jun 2025

Genetically Similar Bacteria Show Unexpected Diversity in Shape and Behavior

Genetically similar bacteria can differ in shape and behavior, even in lab settings. A recent study shows that this variability impacts microbial fitness, virulence, and our understanding of gut microbiota.

26 Jun 2025

Fruit Fly Study Uncovers Key Mechanisms Behind Collective Cell Migration

Researchers uncover how Plexin A and Semaphorin 1b regulate collective cell migration in fruit fly testes, offering insights into organ development, cancer metastasis, and tissue engineering.

26 Jun 2025

Researchers Use Biology to Convert Human Urine into a Valuable Product

Researchers from the Lawrence Berkeley National Laboratory (Berkeley Lab), UC Irvine, and the University of Illinois Urbana-Champaign (UIUC), have used biology to convert human urine into a valuable product.

24 Jun 2025

Organotypic Model of the Human Gut Epithelium Demonstrates Genetic Determinants of Shigella Colonization

A study in Nature Genetics uses organotypic gut models to reveal genome-wide genetic determinants of Shigella colonization, spotlighting type III secretion system effectors as crucial for early infection.

20 Jun 2025

New STAMP Technique Combines Microscopy with Single-Cell RNA Analysis

Single-cell RNA sequencing provides scientists with important information about gene expression in health and disease.

18 Jun 2025

Genetically Modified Yeast Turns Urine into Bone Material

Genetically modified yeast transforms human urine into hydroxyapatite, a valuable biomaterial for bone repair, enhancing wastewater treatment efficiency.

18 Jun 2025

Targeting iRhom2 to Control ADAM17-Related Diseases

The atomic structures of ADAM17 and iRhom2, revealed by UC researchers, offer new avenues for developing precise treatments for chronic inflammatory conditions.

16 Jun 2025

Study Shows Fibronectin Tension Loss Correlates With Breast Cancer Progression

Fibronectin fibers lose tension in invasive breast cancer, unlike in healthy or DCIS tissues, suggesting a mechanical marker for tumor progression.

16 Jun 2025

Study Reveals RNA Polymerase I Stalling Mechanism at Abasic DNA Damage Sites

New study shows RNA polymerase I halts at abasic DNA damage, helping prevent faulty rRNA production and exposing lesions for repair in dividing cells.

16 Jun 2025

New Technique Revolutionizing Single-Cell Analysis with Lower Costs and Greater Scale

A new single-cell RNA analysis method, STAMP, significantly reduces costs and biases, allowing for comprehensive profiling of diverse cell populations.

13 Jun 2025

Study Explores Use of Laser-Patterned Diamonds in Stem Cell Applications

A study in Advanced NanoBiomed Research presents laser-graphitized diamond electrodes that support human mesenchymal stem cell adhesion, alignment, and proliferation, advancing bioelectronic applications.

10 Jun 2025

Myosin XI Helps Plants Absorb Boron Under Nutrient Stress

Boron, though required only in minimal amounts, is vital for plant development. It strengthens cell walls and supports the growth of roots and shoots.

9 Jun 2025

Breakthrough Gene Discovery Uncovers a Master Switch for Food Intake

The Gpr45 gene is linked to food intake regulation, offering insights for obesity therapies. Study utilizes Automated Meiotic Mapping for gene identification.

6 Jun 2025

PPP2R1A Gene Mutations Improve ATR Inhibitor Drug Effectiveness in Ovarian Clear Cell Cancers

A study in Oncogene shows that PPP2R1A mutations increase sensitivity to ATR inhibitors in ARID1A-mutant ovarian clear cell carcinoma, suggesting a potential biomarker for improved treatment strategies.

5 Jun 2025

Ecological Dichotomy in Marine Bacteria During Starvation: Some Move to Find Nutrients, While Others Halt to Conserve Energy

A new study in Nature Microbiology shows that under carbon starvation, marine bacteria split into two strategies: some stop moving to conserve energy, while others keep swimming by consuming biomass—offering new insights into oceanic carbon cycling.

5 Jun 2025