Microscopy

Microscopy is an umbrella term to describe techniques used to analyse small samples that cannot be viewed with the naked eye. There is a wide range of microscopy techniques and scientific instruments available that can be used depending on their applications. A microscope magnifies tiny objects or samples and can provide a wealth of vital information about their cell structure, contamination, parasites and so much more.

This hub will contain all of the information you need to know about microscopy and will include the latest news and fascinating research articles. Whether you are looking to expand your knowledge of compound microscopes or fluorescence microscopy, you will find it all here under featured articles and the latest interviews.

What is Microscopy?

The word microscope is derived from the Greek “mikros”, meaning small and, “skopein” meaning to see.

How do Epifluorescence Microscopes Work?

What is FIB-SEM?

Advantages and Limitations of Fluorescence Microscopy

Live-Cell Imaging with Super-Resolution Microscopy

Advances in Scanning Electron Microscopy

TEM Imaging Modes

Fluorescence Microscopy: An Overview

Confocal Reflection Microscopy for Cell Migration Studies

Visualizing the 3D Architecture of Tissues

Imaging Nuclear Structures Using AFM

Phase-Contrast Microscopy: An Overview

See more featured articles »

The Digital Evolution of Microscopy

What is Environmental Forensic Microscopy?

Using Microscopy for Deep In Vivo Brain Imaging

Optimizing Live Cell Imaging with FRET Microscopy

Applications of IVIS (In Vivo Imaging Systems)

Using Electron Microscopy to Detect Viruses

X-ray Microscopy: An Overview

Investigating the Intersection between Microscopy and Healthcare

Microscopy’s Involvement in Brain Imaging

The Determination of Post-Mortem Interval (PMI) Using Transmission Electron Microscopy

Two-photon Microscopy Principles and Methodology

Intravital Kidney Microscopy: An Overview

What is 3D X-Ray Microscopy?

Avoiding Cell Death in Fluorescence Microscopy

Deep Learning in Fluorescence Microscopy

Role of Microscopy in Ballistics

Microscopy in Oncology Research: Visualizing Tumor Microenvironments

Differentiating Tumors using Microscopy

Diagnosing Alzheimer's Using Microscopy

Applications of Scanning Electron Microscopy

Imaging Techniques in Drug Discovery

‘Staining’ of Biological Samples when Using Electron Microscopy: Why stain density matters

Understanding the Brain Through Electron Microscopy

What is Confocal Imaging?

Optical Microscopy: An Overview

Photobleaching in Fluorescence Microscopy

How Do Spectrometer Accessories Elevate Instrument Capabilities?

What is Expansion Microscopy?

Light Microscopy Techniques in Virology: An Overview

Uses of Microscopy in Forensics

TEM Imaging Modes

Expansion Microscopy in Neurology

Electron Microscopy: An Overview

Identifying Corpses Using Microscopy

Why Size Matters in Microscopy

Cryo-Electron Microscopy: An Overview

Transmission Electron Microscopy: An Overview

Using Scanning Electron Microscopy to Image SARS-CoV-2

Microscopy and Artificial Intelligence

What are Polarized Light Microscopes and How Do They Work?

Scanning Helium Microscopy: An Overview

‘Staining’ of Biological Samples when Using Electron Microscopy: Why stain density matters

Investigating the Applications of Meoscopy

Applications of Polarized Light Microscopy

Optimizing Live Cell Imaging with FRET Microscopy

What is High-Resolution TEM (HR-TEM)?

Advances in Fluorescence Microscopy

Microscopy and Artificial Intelligence

Microscopes in Forensic Epidemiology- An Overview

Scanning Electron Microscopy (SEM): An Overview

Applications of 3D X-ray Microscopy

Confocal Microscopy: An Overview

Light Microscopy Techniques in Virology: An Overview

Latest Microscopy News and Research

EVIDENT to Acquire Pramana, Inc.

Evident announces a definitive agreement to acquire Pramana, Inc., a leading manufacturer of digital pathology solutions.

From EVIDENT 14 Aug 2025

New Water-Based Method Extracts High-Purity Lignin

The Nanoscience Center at the University of Jyväskylä discovered that lignin, a polyphenol vital for plant structure, has an antimicrobial effect against viruses and bacteria.

13 Aug 2025

New Imaging System Reveals Cellular Activity at Unprecedented Depths

Both for research and medical purposes, researchers have spent decades pushing the limits of microscopy to produce ever deeper and sharper images of brain activity, not only in the cortex but also in regions underneath such as the hippocampus.

8 Aug 2025

Parkinson’s Gene Mutation Blocks Vital Neuroprotective Signals

GBA1 mutations impair ciliary Hedgehog signaling in Parkinson's disease, reducing neuroprotective factors and highlighting a shared pathogenic pathway.

7 Aug 2025

New Atomic Force Microscopy Reveals Biofilm Architecture

Scientists at the Department of Energy's Oak Ridge National Laboratory have reimagined the capabilities of atomic force microscopy, or AFM, transforming it from a tool for imaging nanoscale features into one that also captures large-scale biological architecture.

6 Aug 2025

Small Protein LptM Plays Key Role in Assembling Protective Outer Membrane in Bacteria

Gram-negative bacteria pose a significant threat to global health due to their high resistance to antibiotics compared to that of Gram-positive bacteria.

5 Aug 2025

Scientists Uncover New Activation Mechanism of the Human Sweet Taste Receptor

Sweet taste receptors are proteins in taste buds that detect sugar and other sweeteners, but the mechanism underlying how they elicit a sweet response has been unclear.

5 Aug 2025

Mitochondrial Gene Found to Regulate Wood Formation in Poplar

Mitochondria are widely known as the "powerhouses" of the cell, generating the energy needed for life. But in plants, their role goes far beyond metabolism.

31 Jul 2025

New Insights into Yolk Protein Trafficking and Secretion in Worms

Yolk proteins (vitellogenins, VITs) are crucial lipid-carrying molecules that supply nutrients from the mother to embryos in oviparous animals.

28 Jul 2025

How DNA Packaging Shapes p53 Activity

Each cell in our bodies carries about two meters of DNA in its nucleus, packed into a tiny volume of just a few hundred cubic micrometers-about a millionth of a milliliter.

28 Jul 2025

3D-Printed MXene Scaffolds for Brain Injury Recovery

Research on MXene-ECM scaffolds reveals their potential in enhancing electrical stimulation for neural repair, crucial for addressing neurotrauma challenges.

25 Jul 2025

Neuron-Like Telocytes Directly Connect to Stem Cells in the Intestine

In a key advance for regenerative medicine and gut health, scientists from Duke-NUS Medical School and Nanyang Technological University, Singapore (NTU Singapore) have uncovered a precise and unexpected communication system in the gut.

24 Jul 2025

New Insights into How Cilia Move and Power Cellular Motion

A team led by UT Southwestern Medical Center researchers has uncovered the atomic structure of a protein complex pivotal to the function of motile cilia, the hair-like structures extending from the surfaces of many cell types that generate their movement.

23 Jul 2025

Misfolded Proteins in Mitochondria Linked to Type 2 Diabetes

Aging-related diseases, including cancer, cardiovascular disorders and type 2 diabetes, are associated with defects in protein synthesis and folding.

23 Jul 2025

Customizable, Fast-degrading Food Wrap to Cut Landfill

Research on chitosan-PCL films reveals enhanced durability and biodegradability, offering sustainable solutions for food packaging and pollution reduction.

23 Jul 2025

Breakthrough Imaging Technique Reveals Mitochondrial Dynamics in Living Tissues

In this study, researcher developed a new imaging approach that combines two powerful techniques to solve this problem. First, a special type of microscope called a two-photon microscope is used, which can look deep into live tissues with minimal damage.

14 Jul 2025