Microscopy

Microscopy is an umbrella term to describe techniques used to analyse small samples that cannot be viewed with the naked eye. There is a wide range of microscopy techniques and scientific instruments available that can be used depending on their applications. A microscope magnifies tiny objects or samples and can provide a wealth of vital information about their cell structure, contamination, parasites and so much more.

This hub will contain all of the information you need to know about microscopy and will include the latest news and fascinating research articles. Whether you are looking to expand your knowledge of compound microscopes or fluorescence microscopy, you will find it all here under featured articles and the latest interviews.

What is Microscopy?

The word microscope is derived from the Greek “mikros”, meaning small and, “skopein” meaning to see.

Applications of IVIS (In Vivo Imaging Systems)

Imaging Nuclear Structures Using AFM

Advances in Fluorescence Microscopy

Advances in Scanning Electron Microscopy

Cryo-Electron Microscopy: An Overview

Diagnosing Alzheimer's Using Microscopy

Confocal Reflection Microscopy for Cell Migration Studies

‘Staining’ of Biological Samples when Using Electron Microscopy: Why stain density matters

Applications of Polarized Light Microscopy

Deep Learning in Fluorescence Microscopy

Why Size Matters in Microscopy

See more featured articles »

Phase-Contrast Microscopy: An Overview

Identifying Corpses Using Microscopy

Electron Microscopy: An Overview

Microscopy’s Involvement in Brain Imaging

Visualizing the 3D Architecture of Tissues

Microscopes in Forensic Epidemiology- An Overview

The Digital Evolution of Microscopy

Understanding the Brain Through Electron Microscopy

Advantages and Limitations of Fluorescence Microscopy

Avoiding Cell Death in Fluorescence Microscopy

What is Environmental Forensic Microscopy?

Microscopy in Oncology Research: Visualizing Tumor Microenvironments

TEM Imaging Modes

Microscopy and Artificial Intelligence

Uses of Microscopy in Forensics

Optical Microscopy: An Overview

What is Confocal Imaging?

Imaging Techniques in Drug Discovery

Using Electron Microscopy to Detect Viruses

Differentiating Tumors using Microscopy

Fluorescence Microscopy: An Overview

Optimizing Live Cell Imaging with FRET Microscopy

Using Scanning Electron Microscopy to Image SARS-CoV-2

Two-photon Microscopy Principles and Methodology

Light Microscopy Techniques in Virology: An Overview

X-ray Microscopy: An Overview

Intravital Kidney Microscopy: An Overview

Investigating the Applications of Meoscopy

Expansion Microscopy in Neurology

TEM Imaging Modes

What is Expansion Microscopy?

Optimizing Live Cell Imaging with FRET Microscopy

Transmission Electron Microscopy: An Overview

Scanning Helium Microscopy: An Overview

How do Epifluorescence Microscopes Work?

Microscopy and Artificial Intelligence

Photobleaching in Fluorescence Microscopy

Role of Microscopy in Ballistics

‘Staining’ of Biological Samples when Using Electron Microscopy: Why stain density matters

Investigating the Intersection between Microscopy and Healthcare

Applications of Scanning Electron Microscopy

Confocal Microscopy: An Overview

What are Polarized Light Microscopes and How Do They Work?

Using Microscopy for Deep In Vivo Brain Imaging

Light Microscopy Techniques in Virology: An Overview

The Determination of Post-Mortem Interval (PMI) Using Transmission Electron Microscopy

Applications of 3D X-ray Microscopy

How Do Spectrometer Accessories Elevate Instrument Capabilities?

What is High-Resolution TEM (HR-TEM)?

What is FIB-SEM?

Live-Cell Imaging with Super-Resolution Microscopy

Scanning Electron Microscopy (SEM): An Overview

What is 3D X-Ray Microscopy?

Latest Microscopy News and Research

Systematic Platform Accelerates Identification of Novel Protein Degradation Drug Candidates

Investigators at Dana-Farber Cancer Institute have developed a platform for systematically discovering molecular glues that could become protein degradation drug candidates.

6 Aug 2026

Protein Discovery Sheds Light on Scarring Diseases

UK and US scientists have uncovered an important piece of the puzzle on the signaling pathway that causes damaging scar tissue to build up in the body, raising hopes for future treatments.

5 Aug 2026

Sustained Stretching Reshapes Keratin Cytoskeleton in Epithelial Cells

Prolonged mechanical stress induces a dramatic keratin reorganization, affecting nuclear protection and offering insights into cellular resilience mechanisms.

5 Aug 2026

Dynamic Structural Flexibility of Human Norovirus Evade the Immune System

Human norovirus is the leading cause of acute gastroenteritis worldwide and is estimated to infect 600–700 million people each year. Despite its enormous public health impact, no effective antiviral drugs are currently available.

5 Aug 2026

New Research Bypasses Rapid Fungicide Resistance Through Cell Wall Disruption

Powdery mildew is among the most widespread crop diseases, affecting cereals, grapes, cucurbits, tomatoes, fruit crops, and ornamentals in fields and greenhouses.

5 Aug 2026

New Molecular Discoveries Explain How Protein Mutations Regulate Neurological Illnesses

Researchers at Yale School of Medicine have conducted the first comprehensive structural analyses of a class of proteins whose dysfunction is associated with neurodegenerative diseases.

3 Aug 2026

Uncovering New Pathological Pathways Behind Sepsis Triggered Circulatory Failure Risks

Sepsis triggers widespread inflammation, circulatory failure and metabolic stress, and cardiac dysfunction is a common complication associated with sharply poorer outcomes.

3 Aug 2026

New Imaging Workflow Tracks Nanoplastics Distribution in Neonatal Mouse Brains

Nanoplastics-plastic particles smaller than one micrometer-are generated through the degradation and abrasion of plastic products and are increasingly detected in food, drinking water, air, and biological tissues.

30 Jul 2026

Scientists Discover How Heart Muscle Cells Remodel Actin Filaments

Biophysicists unraveled a mystery of how muscles form at the molecular level and how they maintain their function.

30 Jul 2026

Moth Wings Smell Host Plants to Identify Optimal Egg-Laying Spots

Insect wings are bristling with senses, feeling the wind blowing and even tasting potential mates, but little was known about whether moth wings are equipped with a sense of smell.

28 Jul 2026

Dengue Virus Replicates Inside Memory B Cells to Evade Immunity

Researchers at the University of Vermont Robert Larner, M.D. College of Medicine and Upstate Medical University in Syracuse, NY, have discovered that dengue virus can infect and replicate inside memory B cells, immune cells traditionally understood to help protect the body from infection.

28 Jul 2026

Deep-Learning Holography Detects Elusive Circulating Tumor Cells in Prostate Cancer

Researchers combined microfluidic enrichment, AI-assisted holography, and fluorescence profiling to identify circulating tumor cell candidates in 13 men with metastatic castration-resistant prostate cancer and 8 healthy donors. The platform found higher median candidate counts in patients, while nearly two-thirds of PSMA-positive candidates lacked EpCAM, suggesting EpCAM-dependent assays could miss some cells.

27 Jul 2026

A Bio-Based Janus Dressing That Targets Bacteria At Wound Sites

Bio-based furan polyamide dressings effectively direct antibiotic release, offering a sustainable solution for early bacterial control in wounds.

27 Jul 2026

Research Maps Structural Mechanism Linking Amino Acid Availability to Cancer Growth

Cells carry their own growth switches. When enough nutrients-amino acids in particular-are available, cells flip this switch on and begin to grow. Researchers at KAIST and Yonsei University have now uncovered the molecular mechanism by which amino acid signals activate this cellular growth switch.

27 Jul 2026

FlatMux Imaging Platform Captures Live Brain Circuit Activity

The brain is a vast, densely interconnected network of neurons computing in parallel. Watching these computations unfold in real time could reveal how the brain processes sensation and guides behavior.

24 Jul 2026

Tescan Unveils the New CLARA to Help Researchers See More at the Nanoscale

Tescan has introduced the new generation of Tescan CLARA™, an ultra-high-resolution scanning electron microscope for nanoscale materials characterization.

From Tescan 24 Jul 2026

Bacterial TGT Enzyme Engages Two tRNAs to Control Protein Production

The enzyme tRNA-guanine transglycosylase (TGT) chemically modifies transfer RNA (tRNA) and plays a key role in how disease-causing bacteria control the production of proteins needed to cause infection. E. coli TGT is nearly identical to the one found in Shigella, which causes the intestinal infection shigellosis.

23 Jul 2026