Microscopy

Microscopy is an umbrella term to describe techniques used to analyse small samples that cannot be viewed with the naked eye. There is a wide range of microscopy techniques and scientific instruments available that can be used depending on their applications. A microscope magnifies tiny objects or samples and can provide a wealth of vital information about their cell structure, contamination, parasites and so much more.

This hub will contain all of the information you need to know about microscopy and will include the latest news and fascinating research articles. Whether you are looking to expand your knowledge of compound microscopes or fluorescence microscopy, you will find it all here under featured articles and the latest interviews.

What is Microscopy?

The word microscope is derived from the Greek “mikros”, meaning small and, “skopein” meaning to see.

Microscopes in Forensic Epidemiology- An Overview

Scanning Electron Microscopy (SEM): An Overview

Live-Cell Imaging with Super-Resolution Microscopy

Transmission Electron Microscopy: An Overview

Identifying Corpses Using Microscopy

Why Size Matters in Microscopy

Light Microscopy Techniques in Virology: An Overview

Scanning Helium Microscopy: An Overview

Electron Microscopy: An Overview

Using Microscopy for Deep In Vivo Brain Imaging

Imaging Techniques in Drug Discovery

See more featured articles »

Using Scanning Electron Microscopy to Image SARS-CoV-2

Differentiating Tumors using Microscopy

Understanding the Brain Through Electron Microscopy

Microscopy’s Involvement in Brain Imaging

What is Environmental Forensic Microscopy?

Phase-Contrast Microscopy: An Overview

What are Polarized Light Microscopes and How Do They Work?

Applications of Polarized Light Microscopy

Photobleaching in Fluorescence Microscopy

Deep Learning in Fluorescence Microscopy

Applications of 3D X-ray Microscopy

Advances in Scanning Electron Microscopy

Fluorescence Microscopy: An Overview

Microscopy and Artificial Intelligence

‘Staining’ of Biological Samples when Using Electron Microscopy: Why stain density matters

Intravital Kidney Microscopy: An Overview

Two-photon Microscopy Principles and Methodology

‘Staining’ of Biological Samples when Using Electron Microscopy: Why stain density matters

What is High-Resolution TEM (HR-TEM)?

Confocal Microscopy: An Overview

Optimizing Live Cell Imaging with FRET Microscopy

Investigating the Intersection between Microscopy and Healthcare

Advances in Fluorescence Microscopy

Expansion Microscopy in Neurology

Advantages and Limitations of Fluorescence Microscopy

Diagnosing Alzheimer's Using Microscopy

Imaging Nuclear Structures Using AFM

What is Confocal Imaging?

Applications of Scanning Electron Microscopy

What is 3D X-Ray Microscopy?

How Do Spectrometer Accessories Elevate Instrument Capabilities?

Visualizing the 3D Architecture of Tissues

What is Expansion Microscopy?

X-ray Microscopy: An Overview

Cryo-Electron Microscopy: An Overview

Optimizing Live Cell Imaging with FRET Microscopy

The Digital Evolution of Microscopy

TEM Imaging Modes

What is FIB-SEM?

Microscopy and Artificial Intelligence

Investigating the Applications of Meoscopy

Optical Microscopy: An Overview

Uses of Microscopy in Forensics

Microscopy in Oncology Research: Visualizing Tumor Microenvironments

How do Epifluorescence Microscopes Work?

Applications of IVIS (In Vivo Imaging Systems)

Role of Microscopy in Ballistics

The Determination of Post-Mortem Interval (PMI) Using Transmission Electron Microscopy

Light Microscopy Techniques in Virology: An Overview

Confocal Reflection Microscopy for Cell Migration Studies

Avoiding Cell Death in Fluorescence Microscopy

Using Electron Microscopy to Detect Viruses

Latest Microscopy News and Research

Breakthrough Cryo-EM Study Maps Herpes Replication Protein in New Detail

An international research team has successfully identified the initial high-resolution structures of the herpes simplex virus origin-binding protein (OBP), which is an essential element in viral DNA replication that has remained structurally uncharacterized for the past forty years.

24 Oct 2025

Fully Automated 3D Framework Accurately Maps Fruit Microstructure

Applied to apple and pear fruit, the model achieved very high accuracy, outperforming previous 2D approaches and traditional algorithms.

23 Oct 2025

Ingestible Bioprinter Revolutionizes Possibilities for Non-Invasive Tissue Repair

The MEDS device enables non-invasive tissue repair in the GI tract, utilizing innovative bioprinting techniques for effective treatment of internal lesions.

23 Oct 2025

Innovative Fluorescent Technique Sheds Light on Cellular Lipid Transport

Lipids are fatty molecules that play critical roles in cell function, including membrane structure, energy storage and nutrient absorption.

17 Oct 2025

Structural Insights into Heat Shock Chaperone Complex and Protein Handoffs

The first full-length structures of two heat shock chaperone proteins in a complex reveal the key structural region regulating their function, according to a new study from St. Jude Children's Research Hospital.

15 Oct 2025

Smartphone Microscope Detects Single Molecules For Under €350

This innovative smartphone microscope enables direct single-molecule detection and super-resolution imaging, revolutionizing low-cost diagnostics and research.

15 Oct 2025

Masks Attenuate Exposure of Traffic Pollutants’ Adherence to Red Blood Cells

Inhaled traffic pollutants attach to red blood cells, facilitating systemic transport. Wearing FFP" masks lessens this exposure, emphasizing the protective role of masks against air pollution.

10 Oct 2025

New NMR Method Reveals How Enzymes Move During Reactions

Researchers from Tokyo Metropolitan University have developed a new structure determination method using Nuclear Magnetic Resonance (NMR) spectroscopy which shows how different parts of complex molecular machinery like enzymes move while they help catalyze reactions.

6 Oct 2025

New Insights Into How Pathogens Build Protein Machinery for Survival in the Gut

A new study, led by researchers at the University of Liverpool, has revealed how pathogenic bacteria construct tiny protein-based compartments, known as Eut microcompartments, which enable them to digest ethanolamine - a nutrient commonly found in the gut.

3 Oct 2025

Thermo Fisher Scientific Expands Neurodegeneration Research Capabilities with Launch of Olink® Target 48 Neurodegeneration Panel

Thermo Fisher Scientific Inc., the world leader in serving science, today announced the launch of the Olink® Target 48 Neurodegeneration panel, a high-performance, targeted proteomics immunoassay panel developed to accelerate discoveries in neurodegenerative disease research.

From Olink®- Part of Thermo Fisher Scientific 3 Oct 2025

Actin Scaffold Protects Cancer Cell Nuclei Under Mechanical Stress

Researchers from the Cluster of Excellence CIBSS have demonstrated that an actin scaffold stabilizes the cell nucleus upon mechanical stress.

30 Sep 2025

Advanced Workflow Automation and Scalable Image Analysis in Spatial Biology

ZEISS Microscopy and Concept Life Sciences, a UK-based contract research organization (CRO), announced their collaboration aimed at pioneering new approaches to workflow automation and scalable image analysis in spatial biology.

From Concept Life Sciences 26 Sep 2025

Astrocytes Found to Integrate Signals from Multiple Neurons

A collaborative French-Swiss study reveals a previously unknown role for astrocytes in the brain's information processing.

25 Sep 2025

Cryo-EM Study Uncovers Hidden Steps in NMDA Receptor Activation

When it comes to brain proteins, small changes can make a dramatic difference. Researchers studying NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment consciousness, know that even slight changes in their activity level can mean the difference between normal function and serious neurological disorders.

25 Sep 2025