Proteomics, Metabolomics and Lipidomics

The ‘omics revolution ensued from the surge in genetic sequencing seen in the 1990s as scientists aimed to sequence the whole human genome. Advances in sequencing and analytical technologies allowed for increased efficiency and precision, and an integrated, comprehensive approach to understanding organisms followed.
This approach is termed “’omics” and includes the following fields; genomics, transcriptomics, proteomics, fluxomics, and metabolomics. These fields collectively consider all of their respective constituents.
For example, proteomics is the large-scale study of the entire complement of proteins in cell types or organisms. Unlike it’s predecessors, genomics and transcriptomics, proteomics is more complicated as it involves the consideration of post translational modifications, such as phosphorylation. Proteomics has practical applications in protein networks where the study of ways proteins interact aids the field of systems biology, the computational and mathematical analysis and modeling of complex biological systems. Proteomic technologies can be applied to high-throughput techniques, such as mass spectroscopy.
Over the last 30 years, the ’omics have received attention from the research community, the media, and the public alike, largely owing to the advances in scientific understanding that have resulted from ‘omics research. It remains an exciting and fast-paced field of study that is set to continue expanding our knowledge of biological molecules and systems.

Global Market Report: Proteomics

In this article, we discuss the applications of proteomics and its recent developments, along with reviewing the current global market and predicting how the field may evolve in the future.

Global Market Overview: Metabolomics

What is Proteomics?

What is Single-Cell Proteomics?

Racial Differences in Protein Biomarkers

Combining Proteomics and Genomics to Eliminate Disease

Using Omics to Harness the Power of Personalized Nutrition

How is Omics Revolutionizing Cancer Research?

Insight into the Human Proteoform Project

Omics Approaches to Biomarker Analysis

The Role of Metabolomics in Precision Medicine

The Human Metabolome Project

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Role of Applied Omics in Precision Medicine

What is Metabolomics?

Challenges with Standardization in Lipidomics

To the Bone: How Proteomics is Uncovering the Mysteries of Ancient DNA

Ethics in Clinical Proteomics

Applications of Peptidomics

How do we Radiolabel Proteins?

What is Clinical Proteomics?

Understanding Native Protein Characterization

What is 'Bottom-Up' Proteomics?

What is Shotgun Lipidomics?

A Beginners Guide to Plasma Proteomics

Lipidomics in Food Science

Protein Biosynthesis

What are Prions?

Challenges in Environmental Metabolomics

Discovering Misfolded Proteins using Fluorescent Probes

Compound Identification for Nontargeted Metabolomics

Combating Infectious Diseases Through Computational Protein Design

What is Forensic Proteomics?

Eliminating American Foulbrood using Endolysins

Environmental Metabolomics

How are the Metabolome and Proteome Related?

Importance of Lipidomics in Stem Cell Research

Interpreting Proteomics Data

What Role do Proteins Play in Disease?

Metabolomics in Toxicology

What is 4D Proteomics?

What is Phosphoproteomics?

Importance of Blood Serum Calorimetry in Lung Cancer Treatment

What is Protein Ubiquitylation?

What is the Metabolome?

Applications of Bone Proteomics

What are G-Protein-Coupled Receptors?

A Guide to Optimizing Protein Design

Determining Proteins in Milk Using Dumas Analysis

Role of Proteomic Analysis in Skin Regeneration

An Overview of Protein Localization

Liver Disease Biomarkers

What is Pharmacometabolomics?

Protein Degradability

Comparison Between Metabolic Target Analysis and Metabolic Profiling

Analyzing Proteomes Using LC-MS/MS

Challenges in Metabolomic Fingerprinting

The Steps of Protein Synthesis

Effects of Filtered Coffee on Plasma Metabolites

How have Fluorescent Proteins Transformed Science?

Compound Identification for Nontargeted Metabolomics

Combating Counterfeit Green Tea with Metabolomic Profiling

Protein Production: Initiation, Elongation and Termination

What is Phenomics?

Importance of Solubility and Lipophilicity in Drug Development

How does the Proteome Differ Between Individuals?

What is Immunoliposome Therapy?

Heritability Differences in Metabolic Classes

Exploring Biosynthetic Diversity

Pharmacokinetics of Cannabis and its Secondary Metabolites

Understanding Neurobiology through Proteins

The ‘omics’ Revolution

How Can Proteins Help Organisms to Tell the Time?

Role of Proteomics in COVID-19

An Overview of Quantitative Proteomics

What is Western Blotting?

How are Advancements in Mass Spectrometry Impacting Metabolomics Research?

Studying the Metabolic Pathways Between Tissues

Quantifying Protein Diversity: Using DIA-MS to Measure Post-Translational Modifications

Investigating the Evolution of Microbiome Science

How to Analyze Macromolecular Protein Complexes

Cytometric Bead Arrays: A Breakdown of the Technique

Latest Proteomics, Metabolomics and Lipidomics News and Research

Breakthrough Achieved in Completing the Creation of First Synthetic Yeast Genome

Macquarie University researchers have worked with an international team of scientists to achieve a major milestone in synthetic biology by completing the creation of the final chromosome in the world's first synthetic yeast genome.

23 Jan 2025

New Method Enables 20 Color Bioluminescent Imaging for Live Cells

Imaging live cells with fluorescent proteins has long been a crucial technique for understanding cellular behavior. While bioluminescent proteins offer several advantages over fluorescent proteins, the limited availability of color variants has made it difficult to observe multiple targets simultaneously.

23 Jan 2025

Microbiome Signatures Can Predict Nonalcoholic Fatty Liver Disease

Using medical data from more than 1,200 people, specific microbiome signatures have been identified that allow precise prediction of Nonalcoholic Fatty Liver Disease (NAFLD).

22 Jan 2025

Microgravity Unlocks Secrets to Heart Cell Survival for Earth-Based Therapies

A team of researchers led by Emory's Chunhui Xu recently found that heart muscle cells can grow -and survive in the microgravity environment of space.

22 Jan 2025

Discovery Unlocks New Understanding of Autophagy in Health and Disease

A recent study from Tata Institute of Fundamental Research, Mumbai, India has revealed new details about how our cells clean up and recycle waste.

22 Jan 2025

New computational strategy enables design of drug-induced protein interactions

A novel geometric deep learning framework designs ligand-specific protein binders, enhancing therapeutic potential in cell therapies and synthetic biology.

22 Jan 2025

New Technique Unifies Protein Size Measurements to Predict Aggregation Risk

Proteins are necessary for many bodily processes. Numerous physiological functions and activities are carried out by thousands of distinct proteins.

21 Jan 2025

New Insights into the Structure and Function of a Key Viral Protein

Researchers at Harvard Medical School and Boston University Chobanian & Avedisian School of Medicine have mapped a crucial part of the Nipah virus, a deadly bat-borne infection that has been responsible for human outbreaks every year since its discovery in 1999.

21 Jan 2025

Mapping Global Microbial Diversity Using Genomic Sequencing Data

Metagenomic datasets could help map out microbial diversity hotspots. Published January 17, 2025 in Science Advances, researchers at the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science User Facility located at Berkeley Laboratory, have taken stock of the current state of microbial genomic biodiversity.

20 Jan 2025

RNA, Not DNA, Drives Acute Sunburn and Skin Damage

Sunburn has traditionally been attributed to UV-induced DNA damage. However, a new study by the University of Copenhagen and Nanyang Technological University, Singapore, reveals that RNA, another vital cellular molecule, plays a major role in triggering acute sunburn reactions.

20 Jan 2025

Novel Fluorescent Probes Illuminate Cholesterol Dynamics in Live Cells

The quest to find solutions for Alzheimer's disease and other neurodegenerative disorders continues to be one of the most urgent priorities in brain research. According to Maciej J. Stawikowski, Ph.D., an Assistant Professor of Chemistry and Biochemistry at the Charles E. Schmidt College of Science at Florida Atlantic University, the secret might be in comprehending how lipids like cholesterol flow through cells and impact communication.

20 Jan 2025

GET Model Unveils Gene Regulation with Unmatched Accuracy Across Cell Types

GET, a novel computational model, accurately predicts gene activity by analyzing chromatin accessibility and DNA sequences across diverse human cell types.

20 Jan 2025

Deep Sea Foraminifera Species Unveil Secrets of Life in Extreme Environments

Most life on Earth relies on the sun's energy for survival, but what about organisms in the deep sea that live beyond the reach of its rays? A new study led by Woods Hole Oceanographic Institution (WHOI), published in The ISME Journal, sheds light on how a species of foraminifera, single-celled organisms found in almost all marine habitats, thrives in a dark, oxygen-free environment.

17 Jan 2025

Oxygen Sensor Protein Offers Solution for Enhancing Nitrogen Fixation in Plants

A small helper for big tasks: an oxygen sensor protein protects the enzymatic machinery of biological nitrogen fixation from serious damage.

17 Jan 2025

Researchers Develop Method to Produce Strigolactones Using Microbial Cell Factories

Sometimes just using a different tool makes the job a whole lot easier. A team of researchers co-led by the University of California San Diego has developed a method to produce a special class of plant hormones, known as strigolactones, at unprecedented levels using microbial cell factories.

17 Jan 2025

Scientists Discover Surprising Directional Flexibility in DNA-Shaping Motors

Scientists from Delft, Vienna, and Lausanne discovered that the protein machines that shape our DNA can switch direction.

17 Jan 2025

Study Unveils Surprising Cause of Brain Cell Death in Huntington's Disease

Scientists at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntington's disease leads to the death of brain cells.

17 Jan 2025

Inflammasome Helps Block Malignancy in Blood Stem Cells

A group of immune proteins called the inflammasome can help prevent blood stem cells from becoming malignant by removing certain receptors from their surfaces and blocking cancer gene activity, according to a preclinical study by Weill Cornell Medicine investigators.

17 Jan 2025

AI-Powered Platform for Designing Novel Protein Interactions

Researchers at EPFL have opened up a world of possibilities in the computational design of molecular interactions for biomedicine by using deep learning to create new proteins that bind to complexes involving other small molecules, such as hormones or medications.

17 Jan 2025

Researchers Develop Strategy to Boost Pharmaceutical Production in CHO Cells

An international team of researchers led by the University of California San Diego has developed a new strategy to enhance pharmaceutical production in Chinese hamster ovary (CHO) cells, which are commonly used to manufacture protein-based drugs for treating cancer, autoimmune diseases and much more.

16 Jan 2025