Proteomics, Metabolomics and Lipidomics

The ‘omics revolution ensued from the surge in genetic sequencing seen in the 1990s as scientists aimed to sequence the whole human genome. Advances in sequencing and analytical technologies allowed for increased efficiency and precision, and an integrated, comprehensive approach to understanding organisms followed.
This approach is termed “’omics” and includes the following fields; genomics, transcriptomics, proteomics, fluxomics, and metabolomics. These fields collectively consider all of their respective constituents.
For example, proteomics is the large-scale study of the entire complement of proteins in cell types or organisms. Unlike it’s predecessors, genomics and transcriptomics, proteomics is more complicated as it involves the consideration of post translational modifications, such as phosphorylation. Proteomics has practical applications in protein networks where the study of ways proteins interact aids the field of systems biology, the computational and mathematical analysis and modeling of complex biological systems. Proteomic technologies can be applied to high-throughput techniques, such as mass spectroscopy.
Over the last 30 years, the ’omics have received attention from the research community, the media, and the public alike, largely owing to the advances in scientific understanding that have resulted from ‘omics research. It remains an exciting and fast-paced field of study that is set to continue expanding our knowledge of biological molecules and systems.

Global Market Report: Proteomics

In this article, we discuss the applications of proteomics and its recent developments, along with reviewing the current global market and predicting how the field may evolve in the future.

Global Market Overview: Metabolomics

What is Proteomics?

What is Single-Cell Proteomics?

Racial Differences in Protein Biomarkers

Combining Proteomics and Genomics to Eliminate Disease

Using Omics to Harness the Power of Personalized Nutrition

How is Omics Revolutionizing Cancer Research?

Insight into the Human Proteoform Project

Omics Approaches to Biomarker Analysis

The Role of Metabolomics in Precision Medicine

The Human Metabolome Project

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Role of Applied Omics in Precision Medicine

What is Metabolomics?

Challenges with Standardization in Lipidomics

To the Bone: How Proteomics is Uncovering the Mysteries of Ancient DNA

Ethics in Clinical Proteomics

Applications of Peptidomics

How do we Radiolabel Proteins?

What is Clinical Proteomics?

Understanding Native Protein Characterization

What is 'Bottom-Up' Proteomics?

What is Shotgun Lipidomics?

A Beginners Guide to Plasma Proteomics

Lipidomics in Food Science

Protein Biosynthesis

What are Prions?

Challenges in Environmental Metabolomics

Discovering Misfolded Proteins using Fluorescent Probes

Compound Identification for Nontargeted Metabolomics

Combating Infectious Diseases Through Computational Protein Design

What is Forensic Proteomics?

Eliminating American Foulbrood using Endolysins

Environmental Metabolomics

How are the Metabolome and Proteome Related?

Importance of Lipidomics in Stem Cell Research

Interpreting Proteomics Data

What Role do Proteins Play in Disease?

Metabolomics in Toxicology

What is 4D Proteomics?

What is Phosphoproteomics?

Importance of Blood Serum Calorimetry in Lung Cancer Treatment

What is Protein Ubiquitylation?

What is the Metabolome?

Applications of Bone Proteomics

What are G-Protein-Coupled Receptors?

A Guide to Optimizing Protein Design

Determining Proteins in Milk Using Dumas Analysis

Role of Proteomic Analysis in Skin Regeneration

An Overview of Protein Localization

Liver Disease Biomarkers

What is Pharmacometabolomics?

Protein Degradability

Comparison Between Metabolic Target Analysis and Metabolic Profiling

Analyzing Proteomes Using LC-MS/MS

Challenges in Metabolomic Fingerprinting

The Steps of Protein Synthesis

Effects of Filtered Coffee on Plasma Metabolites

How have Fluorescent Proteins Transformed Science?

Compound Identification for Nontargeted Metabolomics

Combating Counterfeit Green Tea with Metabolomic Profiling

Protein Production: Initiation, Elongation and Termination

What is Phenomics?

Importance of Solubility and Lipophilicity in Drug Development

How does the Proteome Differ Between Individuals?

What is Immunoliposome Therapy?

Heritability Differences in Metabolic Classes

Exploring Biosynthetic Diversity

Pharmacokinetics of Cannabis and its Secondary Metabolites

Understanding Neurobiology through Proteins

The ‘omics’ Revolution

How Can Proteins Help Organisms to Tell the Time?

Role of Proteomics in COVID-19

An Overview of Quantitative Proteomics

What is Western Blotting?

How are Advancements in Mass Spectrometry Impacting Metabolomics Research?

Studying the Metabolic Pathways Between Tissues

Quantifying Protein Diversity: Using DIA-MS to Measure Post-Translational Modifications

Investigating the Evolution of Microbiome Science

How to Analyze Macromolecular Protein Complexes

Cytometric Bead Arrays: A Breakdown of the Technique

Latest Proteomics, Metabolomics and Lipidomics News and Research

Frog Egg Extracts Illuminate the Untangling Mechanism of DNA Knots

Research reveals how G-quadruplex DNA structures are untangled, highlighting a role for RNA in genome stability and potential cancer therapy strategies.

13 Jun 2025

Scientists Uncover Cyanobacteria’s Circadian Clockwork

The study uncovers how KaiC regulates circadian rhythms in cyanobacteria through a unique phosphorylation mechanism, offering insights into biological clocks.

13 Jun 2025

Semaphorin 3E Emerges as a Key Factor in Female Reproduction

The discovery of the Sema3E pathway in ovulation by Cornell researchers could enhance understanding of infertility and improve reproductive health strategies.

13 Jun 2025

Femtosecond Crystallography Reveals Cryptochrome Mechanisms

Research on cryptochromes using femtosecond crystallography uncovers rapid structural changes, enhancing our understanding of light-driven biological processes.

11 Jun 2025

New Frontier in Understanding Brain Development and Rare Diseases

A groundbreaking study identifies unknown genetic disorders affecting brain development, offering new insights into neurodevelopmental conditions and diagnoses.

11 Jun 2025

New Platform Technology Promises to Generate Hard-to-Get Human Cells

This study presents a fast method for generating human microglia from iPSCs, paving the way for breakthroughs in neurodegenerative disease research.

11 Jun 2025

The Role of Metabolism in Bacterial Survival and Resistance

Ciprofloxacin induces bioenergetic stress in E. coli, boosting survival rates and resistance development. Metabolic shifts challenge antibiotic effectiveness.

10 Jun 2025

A New Strategy for High-Fidelity CRISPR Editing in Tomatoes

Gene targeting (GT) via homologous recombination (HR) is a powerful tool for precise genome editing, but its application in plants is limited due to the dominance of canonical non-homologous end-joining (cNHEJ) in double-strand break (DSB) repair.

10 Jun 2025

Cryo-EM Structures Reveal How IVD Mutations Cause Isovaleric Acidemia

IVD is a key enzyme in leucine catabolism, catalyzing the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA.

10 Jun 2025

Giant Viruses Discovered to Influence Marine Ecosystems and Algal Blooms

Giant viruses play a role in the survival of single-celled marine organisms called protists. These include algae, amoeba, and flagellates, that form the base of ocean food webs.

9 Jun 2025

Myosin XI Helps Plants Absorb Boron Under Nutrient Stress

Boron, though required only in minimal amounts, is vital for plant development. It strengthens cell walls and supports the growth of roots and shoots.

9 Jun 2025

New Study Reveals Itaconate’s Crucial Functions in Plants

Zhang, T., et al. (2025) The metabolite itaconate is a transcriptional and posttranslational modulator of plant metabolism, development, and stress response. Science Advances. doi.org/10.1126/sciadv.adt7463.

9 Jun 2025

IL-12 Adjuvant Shows Promise in Boosting T-Cell Immunity

Scientists are always searching for new weapons to add to their arsenal in the pursuit of creating vaccinations that would better support the body’s immune system in fending off disease.

9 Jun 2025

Unraveling the Genetic Roots of Anemia in Inflammatory Bowel Disease

One of the most frequent side effects of inflammatory bowel disease, or IBD, is iron deficiency and anemia, which can be made worse by a genetic mutation linked to Crohn’s disease, according to a study conducted by biomedical scientists at the University of California, Riverside School of Medicine.

9 Jun 2025

Zebrafish Model Offers Hope for Treating Ultra-Rare Muscle Disease

Can a small fish help identify possible treatments for an ultra-rare inherited disease found in an Alabama boy? The genetic disease is XMEA, which progressively weakens the muscles and can affect the liver and heart.

6 Jun 2025

Breakthrough Gene Discovery Uncovers a Master Switch for Food Intake

The Gpr45 gene is linked to food intake regulation, offering insights for obesity therapies. Study utilizes Automated Meiotic Mapping for gene identification.

6 Jun 2025

Newly Identified Molecules from Blood Bacterium Show Promise in Combating Skin Aging

Indole metabolites from the blood bacterium P. sanguinis demonstrate potential in anti-aging skin treatments by lowering inflammation and oxidative damage.

6 Jun 2025

Chitin Facilitates Gene Transfer Across Species Through Natural Transformation Among Vibrio cholerae

A study in PNAS reveals that chitin promotes gene transfer in marine environments by binding environmental DNA and enhancing natural transformation in Vibrio cholerae, with implications for microbial evolution and ecosystem diversity.

6 Jun 2025

Camelina Breakthrough Could Transform Natural Astaxanthin Production

In a major step forward for sustainable pigment production, scientists have successfully engineered the oilseed crop Camelina sativa to produce high levels of astaxanthin — a valuable red antioxidant used to color farmed salmon and shrimp — using plant-derived genes rather than bacterial pathways.

6 Jun 2025

UC Davis Study Links Specific microRNAs to Mental and Neurological Disorders

A study in Nature Aging from researchers at the UC Davis School of Medicine has identified specific microRNAs - non-coding RNAs that regulate gene expression within cells - that likely contribute to bipolar disorder, depression, schizophrenia, post-traumatic stress disorder (PTSD) and Parkinson's disease.

5 Jun 2025