Proteomics, Metabolomics and Lipidomics

The ‘omics revolution ensued from the surge in genetic sequencing seen in the 1990s as scientists aimed to sequence the whole human genome. Advances in sequencing and analytical technologies allowed for increased efficiency and precision, and an integrated, comprehensive approach to understanding organisms followed.
This approach is termed “’omics” and includes the following fields; genomics, transcriptomics, proteomics, fluxomics, and metabolomics. These fields collectively consider all of their respective constituents.
For example, proteomics is the large-scale study of the entire complement of proteins in cell types or organisms. Unlike it’s predecessors, genomics and transcriptomics, proteomics is more complicated as it involves the consideration of post translational modifications, such as phosphorylation. Proteomics has practical applications in protein networks where the study of ways proteins interact aids the field of systems biology, the computational and mathematical analysis and modeling of complex biological systems. Proteomic technologies can be applied to high-throughput techniques, such as mass spectroscopy.
Over the last 30 years, the ’omics have received attention from the research community, the media, and the public alike, largely owing to the advances in scientific understanding that have resulted from ‘omics research. It remains an exciting and fast-paced field of study that is set to continue expanding our knowledge of biological molecules and systems.

Global Market Report: Proteomics

In this article, we discuss the applications of proteomics and its recent developments, along with reviewing the current global market and predicting how the field may evolve in the future.

Understanding Neurobiology through Proteins

Heritability Differences in Metabolic Classes

To the Bone: How Proteomics is Uncovering the Mysteries of Ancient DNA

The Steps of Protein Synthesis

Exploring Biosynthetic Diversity

Ethics in Clinical Proteomics

Discovering Misfolded Proteins using Fluorescent Probes

Challenges in Environmental Metabolomics

What Role do Proteins Play in Disease?

Importance of Lipidomics in Stem Cell Research

Determining Proteins in Milk Using Dumas Analysis

See more featured articles »

The ‘omics’ Revolution

The Role of Metabolomics in Precision Medicine

Applications of Peptidomics

Combating Infectious Diseases Through Computational Protein Design

How is Omics Revolutionizing Cancer Research?

Comparison Between Metabolic Target Analysis and Metabolic Profiling

Environmental Metabolomics

What is 'Bottom-Up' Proteomics?

An Overview of Protein Localization

Using Omics to Harness the Power of Personalized Nutrition

A Guide to Optimizing Protein Design

How to Analyze Macromolecular Protein Complexes

How do we Radiolabel Proteins?

What is Proteomics?

Racial Differences in Protein Biomarkers

Effects of Filtered Coffee on Plasma Metabolites

Eliminating American Foulbrood using Endolysins

Interpreting Proteomics Data

How are Advancements in Mass Spectrometry Impacting Metabolomics Research?

Combining Proteomics and Genomics to Eliminate Disease

What is Protein Ubiquitylation?

Challenges in Metabolomic Fingerprinting

What are Prions?

What is Clinical Proteomics?

Analyzing Proteomes Using LC-MS/MS

Cytometric Bead Arrays: A Breakdown of the Technique

Compound Identification for Nontargeted Metabolomics

How does the Proteome Differ Between Individuals?

An Overview of Quantitative Proteomics

What is 4D Proteomics?

How have Fluorescent Proteins Transformed Science?

What are G-Protein-Coupled Receptors?

Role of Proteomics in COVID-19

What is Shotgun Lipidomics?

Protein Production: Initiation, Elongation and Termination

What is Pharmacometabolomics?

What is Single-Cell Proteomics?

How Can Proteins Help Organisms to Tell the Time?

Quantifying Protein Diversity: Using DIA-MS to Measure Post-Translational Modifications

Pharmacokinetics of Cannabis and its Secondary Metabolites

What is Phenomics?

What is Immunoliposome Therapy?

The Human Metabolome Project

Liver Disease Biomarkers

Lipidomics in Food Science

A Beginners Guide to Plasma Proteomics

Role of Applied Omics in Precision Medicine

What is Phosphoproteomics?

Role of Proteomic Analysis in Skin Regeneration

Insight into the Human Proteoform Project

What is Forensic Proteomics?

Importance of Blood Serum Calorimetry in Lung Cancer Treatment

Protein Degradability

Omics Approaches to Biomarker Analysis

Challenges with Standardization in Lipidomics

Global Market Overview: Metabolomics

Investigating the Evolution of Microbiome Science

Applications of Bone Proteomics

Metabolomics in Toxicology

Studying the Metabolic Pathways Between Tissues

Protein Biosynthesis

Understanding Native Protein Characterization

How are the Metabolome and Proteome Related?

Importance of Solubility and Lipophilicity in Drug Development

What is Metabolomics?

Compound Identification for Nontargeted Metabolomics

What is the Metabolome?

What is Western Blotting?

Combating Counterfeit Green Tea with Metabolomic Profiling

Latest Proteomics, Metabolomics and Lipidomics News and Research

Researchers Find Enzyme That Controls Fat Production, Offering New Drug Target

Obesity is a global epidemic and a major cause of morbidity and mortality because it increases the risk for comorbidities, including heart disease and fatty liver disease (MASLD). Rates of these disorders have risen as the world increasingly adopts energy-dense diets and sedentary lifestyles.

24 Dec 2025

Genetic Factor "Fru" Influences Bees' Cooperative Food-Seeking Behavior

A team of biologists from Heinrich Heine University Düsseldorf (HHU), along with researchers from Bochum and Paris, has uncovered a genetic component underlying intricate social behaviors in bees.

24 Dec 2025

UT Southwestern Researchers Design Tau Protein to Combat Neurodegenerative Diseases

A designer version of the tau protein, developed by a team led by UT Southwestern Medical Center researchers, maintains its biological function while resisting aggregation, a pathological trait linked to neurodegenerative diseases called tauopathies. These findings, reported in Structure, could lead to new treatments for conditions including Alzheimer's disease, frontotemporal dementia, chronic traumatic encephalopathy (CTE), and progressive supranuclear palsy.

24 Dec 2025

Kinetic Traps Explain Differences in GPCR Drug Efficacy

G-protein coupled receptors (GPCRs) are proteins triggered by ligands (protein-binding chemicals) from outside cells to transmit signals inside the cell.

23 Dec 2025

Passive Adaptation Balances Protein Synthesis and Degradation in Cells

Every cell depends on proteins to function and stay healthy. These proteins are made inside the cell from amino acids but cannot simply accumulate inside the cell forever.

23 Dec 2025

Protein MCL1 Emerges as a Central Regulator of Cancer Metabolism

The researchers have succeeded in tracing two classic hallmarks of cancer – the evasion of apoptosis (a form of programmed cell death) and the dysregulation of energy metabolism – back to a common molecular mechanism.

23 Dec 2025

Foreign RsMYB28 Allele Boosts Glucosinolate Accumulation in Rapeseed

These bioactive compounds, found primarily in Brassicaceae plants, play crucial roles in plant defense, contribute to distinctive food flavors, and have potential health benefits, including cancer prevention.

23 Dec 2025

Machine Learning Models Identify Early Metabolic Shifts

Acute systemic inflammation has long been suspected to trigger harmful processes within the brain, contributing to neurodegenerative disorders such as Alzheimer's and Parkinson's disease. A new study published online in the Journal of Proteome Research on November 30, 2025, led by Professor Kei Zaitsu from the Faculty of Biology-Oriented Science and Technology, Kindai University, Japan, now provides compelling evidence that such inflammation causes region-specific metabolic disruption, identifying biochemical pathways that fail during the early stages of neuroinflammation.

22 Dec 2025

Study Identifies Protein Target to Overcome Drug Resistance in NSCLC

Lung cancer is the second-most common cancer and the leading cause of cancer death in the United States.

22 Dec 2025

Condensates Introduce a New Paradigm in Cellular Bioelectricity

Many biological processes are regulated by electricity-from nerve impulses to heartbeats to the movement of molecules in and out of cells.

19 Dec 2025

Elusive Kinase State Explains How Cells Achieve Efficient Signaling

Scientists at St. Jude Children's Research Hospital have characterized a hidden intermediate state at the center of Src kinase function. This hidden state allows the kinase to repeatedly modify its target, without needing to release

19 Dec 2025

Genes Can Spread Their Effects Through Shared Microbes

Your "roommate's" genes could be influencing the bacteria living in your gut, and vice versa, according to a study of rats published today in Nature Communications.

19 Dec 2025

Genetic Differences Can Undermine Antibody-Based Therapies

The genome differs from person to person in thousands of positions. In some cases, this means that proteins have a different building block in certain regions, rendering some antibody-based therapies ineffective, report researchers from the University of Basel, Switzerland.

18 Dec 2025

Kefir-Derived Bacteria Show Potential to Reverse Age-Related Immune Decline

The process of aging is associated with a decline in immune functions and persistent low-level inflammation.

18 Dec 2025

Long Non-Coding RNA Found to Directly Control Cell Size

What keeps our cells the right size? Scientists have long puzzled over this fundamental question, since cells that are too large or too small are linked to many diseases.

18 Dec 2025

A Molecular Tug-of-War Shapes Gene Regulation and Disease

A newly revealed molecular tug-of-war may have implications for better understanding how a multitude of diseases and disorders - including cancers, neurodegenerative diseases and immune disorders - originate, as well as how to potentially treat them, according to researchers at Penn State.

18 Dec 2025

Essential Proteins May Have Evolved to Allow Misfolding Repair

Proteins need to fold into specific shapes to perform their functions in cells, but they occasionally misfold, which can prevent them from properly functioning and even lead to disease.

18 Dec 2025

Specific Gut Bacteria Found to Control Weight and Blood Fat Levels

The gut microbiome is intimately linked to human health and weight. Differences in the gut microbiome-the bacteria and fungi in the gut-are associated with obesity and weight gain, raising the possibility that changing the microbiome could improve health.

17 Dec 2025

Understanding the Collaborative Role of Metabolic Proteins

A protein that is crucial for the human body in managing energy and regulating appetite depends on a partner protein, as indicated by recent research, and these findings may assist researchers in gaining a deeper understanding of genetic obesity.

17 Dec 2025

CNSA Advances Open Biological Data Infrastructure at Petabyte Scale

Advances in sequencing technologies have transformed life science research, enabling multi-layered exploration of biological systems across species, tissues, and developmental stages.

15 Dec 2025