Proteomics, Metabolomics and Lipidomics

The ‘omics revolution ensued from the surge in genetic sequencing seen in the 1990s as scientists aimed to sequence the whole human genome. Advances in sequencing and analytical technologies allowed for increased efficiency and precision, and an integrated, comprehensive approach to understanding organisms followed.
This approach is termed “’omics” and includes the following fields; genomics, transcriptomics, proteomics, fluxomics, and metabolomics. These fields collectively consider all of their respective constituents.
For example, proteomics is the large-scale study of the entire complement of proteins in cell types or organisms. Unlike it’s predecessors, genomics and transcriptomics, proteomics is more complicated as it involves the consideration of post translational modifications, such as phosphorylation. Proteomics has practical applications in protein networks where the study of ways proteins interact aids the field of systems biology, the computational and mathematical analysis and modeling of complex biological systems. Proteomic technologies can be applied to high-throughput techniques, such as mass spectroscopy.
Over the last 30 years, the ’omics have received attention from the research community, the media, and the public alike, largely owing to the advances in scientific understanding that have resulted from ‘omics research. It remains an exciting and fast-paced field of study that is set to continue expanding our knowledge of biological molecules and systems.

Global Market Report: Proteomics

In this article, we discuss the applications of proteomics and its recent developments, along with reviewing the current global market and predicting how the field may evolve in the future.

Role of Applied Omics in Precision Medicine

Combating Infectious Diseases Through Computational Protein Design

Role of Proteomics in COVID-19

Liver Disease Biomarkers

The Steps of Protein Synthesis

What Role do Proteins Play in Disease?

Pharmacokinetics of Cannabis and its Secondary Metabolites

Compound Identification for Nontargeted Metabolomics

Importance of Solubility and Lipophilicity in Drug Development

Protein Biosynthesis

Challenges with Standardization in Lipidomics

See more featured articles »

What is Shotgun Lipidomics?

Combating Counterfeit Green Tea with Metabolomic Profiling

What is the Metabolome?

Determining Proteins in Milk Using Dumas Analysis

A Guide to Optimizing Protein Design

What is Immunoliposome Therapy?

Challenges in Environmental Metabolomics

Applications of Bone Proteomics

Environmental Metabolomics

How is Omics Revolutionizing Cancer Research?

Racial Differences in Protein Biomarkers

Understanding Native Protein Characterization

Global Market Overview: Metabolomics

How have Fluorescent Proteins Transformed Science?

What is Phenomics?

What is Clinical Proteomics?

Quantifying Protein Diversity: Using DIA-MS to Measure Post-Translational Modifications

Role of Proteomic Analysis in Skin Regeneration

Understanding Neurobiology through Proteins

To the Bone: How Proteomics is Uncovering the Mysteries of Ancient DNA

How do we Radiolabel Proteins?

What are Prions?

A Beginners Guide to Plasma Proteomics

Challenges in Metabolomic Fingerprinting

Metabolomics in Toxicology

Eliminating American Foulbrood using Endolysins

Omics Approaches to Biomarker Analysis

What is Protein Ubiquitylation?

What is Proteomics?

Cytometric Bead Arrays: A Breakdown of the Technique

Ethics in Clinical Proteomics

An Overview of Quantitative Proteomics

What is Phosphoproteomics?

What is Single-Cell Proteomics?

An Overview of Protein Localization

Studying the Metabolic Pathways Between Tissues

Effects of Filtered Coffee on Plasma Metabolites

How Can Proteins Help Organisms to Tell the Time?

How are Advancements in Mass Spectrometry Impacting Metabolomics Research?

What is Metabolomics?

Importance of Lipidomics in Stem Cell Research

Discovering Misfolded Proteins using Fluorescent Probes

How to Analyze Macromolecular Protein Complexes

What is Forensic Proteomics?

Insight into the Human Proteoform Project

Applications of Peptidomics

What is Western Blotting?

How are the Metabolome and Proteome Related?

Comparison Between Metabolic Target Analysis and Metabolic Profiling

What is 'Bottom-Up' Proteomics?

Importance of Blood Serum Calorimetry in Lung Cancer Treatment

What is 4D Proteomics?

Using Omics to Harness the Power of Personalized Nutrition

Investigating the Evolution of Microbiome Science

Interpreting Proteomics Data

The ‘omics’ Revolution

The Human Metabolome Project

What is Pharmacometabolomics?

Combining Proteomics and Genomics to Eliminate Disease

Heritability Differences in Metabolic Classes

Compound Identification for Nontargeted Metabolomics

Analyzing Proteomes Using LC-MS/MS

What are G-Protein-Coupled Receptors?

Protein Production: Initiation, Elongation and Termination

Exploring Biosynthetic Diversity

Lipidomics in Food Science

The Role of Metabolomics in Precision Medicine

How does the Proteome Differ Between Individuals?

Protein Degradability

Latest Proteomics, Metabolomics and Lipidomics News and Research

Study Reveals How Trypanosomes Fine-Tune Protein Production Through Destruction

To survive in the human bloodstream, the African trypanosome parasite wears a "cloak" made of proteins known as a variant surface glycoprotein (VSG). The study, published in Nature Microbiology, identifies the protein that allows the parasite to fine-tune this "cloak".

31 Mar 2026

Study Links ER Stress From Fat Buildup to Senescence

When cells experience enough chronic stress, they can stop dividing permanently. In this state of cellular limbo, known as replicative senescence, cells remain alive but no longer proliferate.

31 Mar 2026

Novel Immunotherapy Disrupts the Protective Tumor Microenvironment Ecosystem

Chimeric antigen receptor T-cell therapy - CAR T for short - has been a major advance in treating blood cancers like leukemia and lymphoma. But the immunotherapy has struggled against solid tumors for two main reasons: tumor cells often don't share one consistent surface target, and many solid tumors are protected by a dense network of scar tissue and immune-suppressive cells that blocks T cells.

31 Mar 2026

Sweat Peptide Dermcidin Prevents Flu Virus Entry Into Cells

A research team led by the Fisabio Foundation has demonstrated that dermcidin, an antimicrobial peptide produced constitutively by the human body, also exhibits antiviral activity against the influenza virus. The study also shows that people who do not develop flu-like symptoms have higher baseline levels of this molecule, which could be associated with lower susceptibility to infection.

31 Mar 2026

Study Highlights the Vast Untapped Potential Within the Global Protein Universe

The number of known proteins is infinitely small in comparison to the universe of possible proteins which could in theory be realized. Yet these known proteins are the only major training ground for future protein design. Understanding how representative these proteins are of the overall potential diversity can therefore help inform strategies for a wide range of applications, including therapeutic, biocatalysis, or biomaterials development.

31 Mar 2026

New Computational Tools Improve Gene Function Determination Within Fungal Organisms

While RNA sequencing (RNA-seq) has become a standard tool for profiling which genes are active in an organism, determining the actual biological functions of those genes in fungi remains a significant technical challenge. Most existing software tools are designed to cover a broad range of species, often lacking the specificity required for the unique genetic landscape of fungi.

31 Mar 2026

Identifying the Cellular Origin of MS-Related Neuroinflammation

Signals from the gut have been linked to autoimmune inflammation, but fundamental cellular processes remain poorly understood.

30 Mar 2026

Genome-Wide Screen Reveals Drivers of Ciprofloxacin Tolerance Mechanisms

Persisters are a bacterial subpopulation that exhibits tolerance to antibiotics and plays a critical role in chronic and recurrent infections.

28 Mar 2026

Fusion Protein Rewires Brain Development to Trigger Pediatric Cancer

A team of researchers at Baylor College of Medicine, St. Jude Children's Research Hospital, Texas Children's Hospital and collaborating institutions reveal in the journal Nature a novel mechanism that drives the development of pediatric supratentorial ependymoma (EPN), the third most common pediatric brain tumor.

28 Mar 2026

Study Reveals How STING Protein Migrates to Trigger Immune Responses

UT Southwestern Medical Center researchers have identified how the quintessential immune protein known as stimulator of interferon genes (STING) migrates from one cellular organelle to another, a necessary step in its activation.

27 Mar 2026

Microtubules Act as Active Regulators of Key Cellular Enzymatic Reactions

Microtubules, the dynamic filaments that form the cell's internal scaffolding, have long been viewed as mere passive structural supports. But a new study reveals they play a far more active signaling role.

27 Mar 2026

Newly Discovered CRISPR System Activates Genes Without Cutting DNA

In back-to-back studies published in Nature, researchers from Purdue University and Columbia University report a naturally evolved gene-editing system that can activate genes, offering an advantage over existing CRISPR gene-editing systems that merely find and cut DNA.

26 Mar 2026

SLIT3 Protein Drives Brown Fat Activation Through Dual Signaling

Researchers have determined how a key protein activates brown fat by expanding blood vessels and nerves in the heat-generating tissue.

26 Mar 2026

Study Reveals Molecular Basis of Reduced Cold Sensitivity in Salamanders

The ability to sense environmental temperature, which helps animals move away from sub-optimal locations and find those with ideal temperatures, involves various channels on sensory neurons that open at specific temperature ranges.

26 Mar 2026

Reversing Memory Loss in Aging Mice by Targeting Gut Bacteria

The study uncovers how gut bacteria like Parabacteroides goldsteinii contribute to memory decline, offering insights for potential cognitive interventions.

26 Mar 2026

Synthetic Plasmid Design Enables Precise Control of DNA Replication

"If it ain't broke, don't fix it," goes the old adage, which Rice University professor James Chappell completely ignored in a recent Nature Communications publication.

26 Mar 2026

NAC Complex Triggers Protein Folding at Earliest Stage of Synthesis

In the earliest phase of creating human proteins, the protein complex NAC performs an essential task by starting the first steps towards folding proteins into their correct three-dimensional structures.

24 Mar 2026

New PanNDA Atlas Maps Protein Networks in Neurodegenerative Diseases

Neurodegenerative diseases form a tangled biological web with overlapping molecular signatures and symptoms. To decode this complexity, a multi-institute collaboration led by St. Jude Children's Research Hospital scientists developed the pan-neurodegeneration atlas (PanNDA).

24 Mar 2026

Scientists Map Gene Sharing Networks in Wastewater Treatment Biofilms

Wastewater treatment systems are hotspots for mobile genetic elements proliferation and exchange, where dense biofilms create ideal conditions for horizontal gene transfer.

24 Mar 2026

SHP Protein Slows Cartilage Degeneration in Osteoarthritis

Osteoarthritis, a condition that causes pain and reduced mobility in joints such as the knees and fingers, is one of the most common joint disorders worldwide, particularly among aging populations.

24 Mar 2026