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St. Jude Scientists Discover Hidden Binding Pocket in Nuclear Receptors

A study from St. Jude Children's Research Hospital uncovered an alternative binding pocket within nuclear receptors, revealing a much-needed new therapy route for this important class of drug targets.

7 Nov 2025

Comprehensive Kinase Atlas Redefines Regulation of Gene Transcription Machinery

The enzyme RNA polymerase II transcribes genes into messenger RNA. This process is guided by modifications to the enzyme's "tail" called phosphorylation patterns.

7 Nov 2025

TRV-Mediated Gene Editing System Transforms Tomato Functional Genomics

CRISPR-Cas9 has revolutionized plant genome editing, yet its application in tomato remains limited due to the plant's recalcitrance to transformation and regeneration.

7 Nov 2025

New Tool Merges Ex-Vivo and In-Vivo Brain Data for White Matter Research

BraDiPho is an innovative tool for the study of white matter connections in the human brain. A realistic map developed by a group of researchers from the University of Trento, the Provincial Healthcare Service of Trento, Fondazione Bruno Kessler and the Universities of Bordeaux and Sherbrooke.

7 Nov 2025

Scientists Reveal Nonenzymatic Role of NUDT5 in Purine Pathway Regulation

Inside every cell, a finely tuned metabolic network determines when to build, recycle, or stop producing essential molecules.

7 Nov 2025

Transforming Stomach Cells into Insulin Factories for Diabetes Treatment

Type 1 diabetes is caused by an insufficient production of the hormone insulin by cells in the pancreas called beta cells and estimated to affect 9.5 million people worldwide.

7 Nov 2025

Atomic Structure of Kinesin-2 Reveals the Molecular Logic of Cargo Recognition

For decades, scientists have known that motor proteins like kinesin-2 ferry vital cargo along microtubule "highways" inside cells.

7 Nov 2025

Decoding DNA’s Spatial Organization With Precision Tools

DNA is more than simply a lengthy string of genetic code; it is a complex three-dimensional structure folded inside each cell. That means that the equipment used to examine DNA must be as sophisticated, capable of reading not just the code itself but also its spatial arrangement.

7 Nov 2025

Muscle Tissue from a 3D Printer – Produced in Zero Gravity

On their way into space, astronauts' bodies deteriorate dramatically in zero gravity. To address this problem and protect our pioneers in space, researchers are looking for realistic test models.

7 Nov 2025

Using AI and "Protein Language" Models to Speed Monoclonal Antibody Design

Artificial intelligence (AI) and "protein language" models can speed the design of monoclonal antibodies that prevent or reduce the severity of potentially life-threatening viral infections, according to a multi-institutional study led by researchers at Vanderbilt University Medical Center.

6 Nov 2025

Oxidative Stress May Hold Clues to the Origins of Repetitive Behaviors

Abnormal repetitive behaviors in mice are strongly linked to multiple biomarkers of oxidative stress, which occurs when antioxidants cannot counteract the effects of harmful molecules in the body, according to a study published November 5, 2025, in the open-access journal PLOS One by Kendall Coden and Dr. Joseph Garner of Stanford University, U.S.

6 Nov 2025

Two Genetic Mapping Approaches Reveal Distinct Sides of Disease Biology

The two main approaches for discovering disease genes reveal distinct aspects of biology, a new study shows.

6 Nov 2025

Ferroptosis Suppression Identified as a Key Driver of Lung Cancer Growth

NYU Langone Health researchers found that a type of cell death caused by a buildup of highly reactive molecules suppresses lung tumor growth.

6 Nov 2025

Breakthrough Genomic Technique Expands View of Ocean Microbial Life

A new method vastly improves on the existing approach for single-cell genetic sequencing, enabling scientists to read the genomes of individual cells and viral particles in the environment more quickly, efficiently, and cost-effectively.

6 Nov 2025

3D Ultrasound That Sees Entire Organ Blood Flow in Real Time

This study presents a multi-lens ultrasound system that offers tenfold higher resolution for whole-organ imaging, improving microvascular network visualization.

6 Nov 2025

Iowa State Researchers Highlight the Power of Genomic Selection in Modern Agriculture

Developing high-yielding, nutritious and climate-resilient crops is vital to safeguard the future of global food production.

5 Nov 2025

Warmer Temperatures Drive Faster Immune Responses Through Myosin II Activation

Temperature is a key physiological factor that determines the speed of immune reactions. While this may seem obvious, it has remained largely unexplored at the single-cell level-until now.

5 Nov 2025

Molecular Dynamics Simulations Accurately Recreate the RNA Folding Process

Ribonucleic acid (RNA) is one of life's most versatile molecules, with roles going far beyond being a messenger of genetic code, as it is fundamentally involved in gene regulation, processing, and maintenance across all living systems.

5 Nov 2025

Your Washing Machine Isn’t As Clean As You Think

Washing machines may harbor microbes linked to hygiene risks. Study reveals user-specific microbial profiles and the impact of machine design on contamination.

5 Nov 2025

Study Reveals How Certain E. coli Strains can Spread as Rapidly as Viruses

Experts can now predict the transmission rate of a bacterial E. coli infection in the same way as they can for viral pandemics, which can help battling treatment-resistant infections in the future.

5 Nov 2025