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Sabotaging T Cell Exhaustion for Cancer Therapy

Like all hardworking things, the cytotoxic T lymphocytes (CTLs) of the immune system charged with detecting and destroying cancer cells tend to get very tired-so much so, in fact, that they can even die from exhaustion.

18 Nov 2025

Neurons and Other Nondividing Cells Respond Differently to CRISPR-Cas9 Gene Editing

The gene editing tool known as CRISPR-Cas9 is changing what's possible for treating a wide range of diseases caused by genetic mutations.

18 Nov 2025

Researchers Discover Molecular Switch That Helps Breast Cancer Cells Survive Stress

Cells are regularly faced with environmental stresses that may damage or destroy them. To survive, they quickly adjust their gene expression to protect themselves.

18 Nov 2025

Researchers Reveal How the Brain Forms Hidden-State Inferences

Animals survive in changing and unpredictable environments by not merely responding to new circumstances, but also, like humans, by forming inferences about their surroundings-for instance, squirrels understand that certain bird noises don't signal the presence of a predator, so won't seek shelter when they later hear these same sounds.

18 Nov 2025

CRISPR Gene Editing Reverses Chemotherapy Resistance in Lung Cancer

In a major step forward for cancer care, researchers at ChristianaCare's Gene Editing Institute have shown that disabling the NRF2 gene with CRISPR technology can reverse chemotherapy resistance in lung cancer. The approach restores drug sensitivity and slows tumor growth.

18 Nov 2025

Blocking a Hidden Tumor Pathway Revives the Immune System

A new study has discovered a molecular signal that tumors exploit to exhaust the T cells meant to destroy them-and how silencing that signal could revive the body's immunity.

18 Nov 2025

Optical Genome Mapping Reveals Overlooked Causes of Pregnancy Loss

Pregnancy loss may occur in as many as 25% of all pregnancies. Most of these losses occur in the first trimester, and about half are caused by genetic or chromosomal issues.

18 Nov 2025

Exploring Carotenoid Diversity in Carrots Through Gene Editing

Carrots are rich in carotenoids, essential for human health, providing important compounds like vitamin A.

17 Nov 2025

Targeted Genetic Testing Revolutionizes Diagnosis of X-Linked Dystonia-Parkinsonism

Scientists at Brigham and Women's Hospital and Harvard Medical School have developed a targeted genetic test to improve diagnosis for X-linked dystonia-parkinsonism (XDP), a rare and disabling movement disorder that affects primarily men of Filipino ancestry.

17 Nov 2025

Reviving Ancient DNA Techniques to Study Historical Disease Evolution

Research institutions around the world house valuable genetic information that could help unlock countless medical mysteries.

17 Nov 2025

Understanding Genetic Diversity Through Short Tandem Repeats

Scientists at The Hospital for Sick Children (SickKids) have revealed a previously overlooked layer of genetic variation that could help explain why people experience disease differently, and why some treatments work better for certain populations.

17 Nov 2025

Breakthrough Microscope Enhances Detection Range for Cellular Observations

Researchers Kohki Horie, Keiichiro Toda, Takuma Nakamura, and Takuro Ideguchi of the University of Tokyo have built a microscope that can detect a signal over an intensity range fourteen times wider than conventional microscopes.

17 Nov 2025

Molecular Test Targets Three Significant Pathogenic Fungi

This innovative assay detects key fungal pathogens with 100% accuracy, addressing urgent diagnostic needs for infections affecting immunocompromised patients.

17 Nov 2025

Positioning Barbados as the Caribbean’s Life Sciences Hub

Export Barbados (BIDC) and EarlyHealth Group (EHG), have signed a Letter of Intent to jointly establish EarlyHealth City Barbados, a US$200 Million world-class pharmaceutical and life sciences cluster earmarked for Newton, Christ Church.

17 Nov 2025

RNA Imaging Predicts Early Cell Damage with High Sensitivity

NIMS, in collaboration with Nagoya University, Gifu University, and the University of Adelaide, has developed a method for simultaneously imaging DNA and RNA inside cells using harmless infrared to near-infrared light.

14 Nov 2025

Cellarity's AI Model Predicts Drug Induced Liver Injury

Cellarity, a clinical-stage biotechnology company developing Cell State-Correcting therapies through integrated multi-omics and AI modeling, today announced the publication of a seminal manuscript in Nature Communications, which describes a novel framework for the prediction and characterization of drug-induced liver injury (DILI), along with open-source posting of the model and validation data.

14 Nov 2025

Studying Disease Evolution Through Ancient DNA Analysis

Research institutions around the world house valuable genetic information that could help unlock countless medical mysteries. However, because DNA degrades over time, it is difficult for researchers to analyze DNA samples older than 20 years using conventional analytical approaches.

14 Nov 2025