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A New Strategy for High-Fidelity CRISPR Editing in Tomatoes

Gene targeting (GT) via homologous recombination (HR) is a powerful tool for precise genome editing, but its application in plants is limited due to the dominance of canonical non-homologous end-joining (cNHEJ) in double-strand break (DSB) repair.

10 Jun 2025

Cryo-EM Structures Reveal How IVD Mutations Cause Isovaleric Acidemia

IVD is a key enzyme in leucine catabolism, catalyzing the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA.

10 Jun 2025

Study Explores Use of Laser-Patterned Diamonds in Stem Cell Applications

A study in Advanced NanoBiomed Research presents laser-graphitized diamond electrodes that support human mesenchymal stem cell adhesion, alignment, and proliferation, advancing bioelectronic applications.

10 Jun 2025

Targeting the Chagas Parasite by Interrupting Its Lifecycle

Chagas disease is often called a silent killer because many people don't realize they have it until complications from the infection kill them.

9 Jun 2025

Giant Viruses Discovered to Influence Marine Ecosystems and Algal Blooms

Giant viruses play a role in the survival of single-celled marine organisms called protists. These include algae, amoeba, and flagellates, that form the base of ocean food webs.

9 Jun 2025

Mapping the Genetic Blueprint of Flowering Chinese Cabbage

Flowering Chinese cabbage (Brassica rapa ssp. chinensis var. parachinensis), known for its tender stalks and vibrant greens, has long been a dietary mainstay in southern China and beyond.

9 Jun 2025

Myosin XI Helps Plants Absorb Boron Under Nutrient Stress

Boron, though required only in minimal amounts, is vital for plant development. It strengthens cell walls and supports the growth of roots and shoots.

9 Jun 2025

Distinct Neural Patterns Reveal How Mice Navigate Ambiguous Landmarks

When navigating a place that we're only somewhat familiar with, we often rely on unique landmarks to help make our way.

9 Jun 2025

Y Chromosome Loss Weakens Cancer Immunity

When cancer cells in male patients and immune cells in their tumors both lose the Y chromosome, those patients tend to experience poorer outcomes than patients without Y chromosome loss, according to new findings from Cedars-Sinai investigators.

9 Jun 2025

New Study Reveals Itaconate’s Crucial Functions in Plants

Zhang, T., et al. (2025) The metabolite itaconate is a transcriptional and posttranslational modulator of plant metabolism, development, and stress response. Science Advances. doi.org/10.1126/sciadv.adt7463.

9 Jun 2025

IL-12 Adjuvant Shows Promise in Boosting T-Cell Immunity

Scientists are always searching for new weapons to add to their arsenal in the pursuit of creating vaccinations that would better support the body’s immune system in fending off disease.

9 Jun 2025

Unraveling the Genetic Roots of Anemia in Inflammatory Bowel Disease

One of the most frequent side effects of inflammatory bowel disease, or IBD, is iron deficiency and anemia, which can be made worse by a genetic mutation linked to Crohn’s disease, according to a study conducted by biomedical scientists at the University of California, Riverside School of Medicine.

9 Jun 2025

Zebrafish Model Offers Hope for Treating Ultra-Rare Muscle Disease

Can a small fish help identify possible treatments for an ultra-rare inherited disease found in an Alabama boy? The genetic disease is XMEA, which progressively weakens the muscles and can affect the liver and heart.

6 Jun 2025

Bacteria Navigate Terrain by Exploiting Fluid Landscapes Around Yeast

In the world of microorganisms, microbes compete for turf, spew chemicals at foes, and sometimes exploit the microscopic terrain to gain an edge.

6 Jun 2025

Cleaner Fish Stations and Their Effect on Reef Diversity

This study reveals how cleaner fish impact microbial diversity on coral reefs, highlighting their role in ecosystem health and potential pathogen transmission.

6 Jun 2025

Breakthrough Gene Discovery Uncovers a Master Switch for Food Intake

The Gpr45 gene is linked to food intake regulation, offering insights for obesity therapies. Study utilizes Automated Meiotic Mapping for gene identification.

6 Jun 2025

Newly Identified Molecules from Blood Bacterium Show Promise in Combating Skin Aging

Indole metabolites from the blood bacterium P. sanguinis demonstrate potential in anti-aging skin treatments by lowering inflammation and oxidative damage.

6 Jun 2025

Chitin Facilitates Gene Transfer Across Species Through Natural Transformation Among Vibrio cholerae

A study in PNAS reveals that chitin promotes gene transfer in marine environments by binding environmental DNA and enhancing natural transformation in Vibrio cholerae, with implications for microbial evolution and ecosystem diversity.

6 Jun 2025

Camelina Breakthrough Could Transform Natural Astaxanthin Production

In a major step forward for sustainable pigment production, scientists have successfully engineered the oilseed crop Camelina sativa to produce high levels of astaxanthin — a valuable red antioxidant used to color farmed salmon and shrimp — using plant-derived genes rather than bacterial pathways.

6 Jun 2025

UC Davis Study Links Specific microRNAs to Mental and Neurological Disorders

A study in Nature Aging from researchers at the UC Davis School of Medicine has identified specific microRNAs - non-coding RNAs that regulate gene expression within cells - that likely contribute to bipolar disorder, depression, schizophrenia, post-traumatic stress disorder (PTSD) and Parkinson's disease.

5 Jun 2025