Antibodies and Immunology

What are Therapeutic Antibodies?

Recent years have seen therapeutic antibodies, specifically, monoclonal antibodies, grow rapidly in their use in treating a range of diseases and illnesses.

Research Developments in Monoclonal Antibodies

Antibody-Antigen Recognition- How Does it Work?

Creating a Nanobody Library with PCR

Purifying Antibodies Using Ion Exchange Chromatography

VHH Antibodies (Nanobodies) Advantages and Limitations

Latest Antibodies and Immunology News and Research

Newly discovered biomarkers predict response to immunotherapy in Type 1 diabetes

Scientists at UCL have discovered new biomarkers, which may identify those people with Type 1 diabetes who would benefit from the immunotherapy drug Abatacept, a finding which could eventually help thousands manage the disease more effectively.

4 Aug 2020

Old part of immune system may influence severity of COVID-19

One of the immune system's oldest branches may be influencing the severity of COVID disease, according to a new study from researchers.

4 Aug 2020

Detecting rare circulating tumor cells

Metastasis - the development of tumor growth at a secondary site - is responsible for the majority of cancer-related deaths.

4 Aug 2020

A simple screening process may improve mAb-based drug development

By screening potential monoclonal antibody (mAb)-based drugs solely based on a measure of their colloidal stability, scientists may be able to weed out mAbs that do not respond efficiently in solution early in the drug discovery process, according to a new study.

3 Aug 2020

Re-engineering antibodies to fight SARS-CoV-2 infection

With millions of COVID-19 cases reported across the globe, people are turning to antibody tests to find out whether they have been exposed to the coronavirus that causes the disease.

31 Jul 2020

Researchers create a new mouse model for studying glioblastoma

More than 200 genes with novel and known roles in glioblastoma - the most aggressive type of brain cancer - offer promising new drug targets.

30 Jul 2020

Rapid drug development yields potential treatment for yellow fever

Yellow fever, a hemorrhagic disease that is common in South America and sub-Saharan Africa, infects about 200,000 people per year and causes an estimated 30,000 deaths.

30 Jul 2020

Researchers show how gut microbiomes change the nature of cancer mutations

It is a fact that has long baffled doctors: Cancer in the small intestine is quite rare, whereas colorectal cancer, a neighboring though much smaller organ, is one of the leading causes of cancer death for men and women. What is it about the colon that seems to "attract" cancer?

30 Jul 2020

CBT helps food allergic children with severe phobia of anaphylaxis

Imagine a young girl with a peanut allergy, so stricken by fear of anaphylaxis that she no longer takes part in everyday activities many children take for granted.

29 Jul 2020

Study may lead to new therapeutic approaches against coronaviruses

The immune system secretes an endogenous protein that can strongly suppress coronaviruses, the pathogen that is responsible for causing the current pandemic.

29 Jul 2020

Researchers identify phosphoprotein biomarkers to guide cancer therapy

Precision medicine in cancer treatment uses genetic changes in the cancer cells to select the best therapies for individual patients.

29 Jul 2020

Discovering the Critical Role of Astrocytes in Neurodegenerative Diseases

AZoLifeSciences talks to Dr. Shane Liddelow about their research into discovering the critical role of astrocytes in neurodegenerative diseases like glaucoma.

29 Jul 2020

Novel label-free imaging method can differentiate between quiescent and activated T cells

T cells are the immune soldiers at the frontlines of the battle with infiltrating pathogens that seek to cause disease. A new study published in Nature Biomedical Engineering describes a novel label-free imaging technique that can differentiate active T cells from those off duty.

28 Jul 2020

Rare gene mutation eliminates immune cell population

A study has allowed researchers to identify a rare human gene mutation that removes a population of immune cells, called mucosal-associated invariant T cells.

27 Jul 2020

New study shows how T cells function in atherosclerosis

High cholesterol kills. In fact, one in four Americans will die from the consequences of atherosclerosis, the buildup of plaques of fat and cholesterol in the arteries. Statins have helped reduce mortality, but millions are still at risk.

27 Jul 2020

Higher levels of specific protein linked with severity of COVID-19 symptoms

A new study found raised levels of transforming growth factor beta-induced protein (TGFBIp) in blood sampled from roughly 100 people hospitalized for COVID-19, and further found that elevated levels of both the normal and acetylated forms of TGFBIp correlated with the severity of disease symptoms in these patients.

27 Jul 2020

Experimental mRNA-based vaccine protects animals against SARS-CoV-2

An experimental messenger RNA (mRNA)-based vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) elicits protective immune responses in mice and non-human primates, researchers report on July 23rd in the journal Cell.

27 Jul 2020

New technology can speed up drug development for tuberculosis

A novel technology that integrates machine learning and high-throughput imaging could accelerate drug discovery to fight tuberculosis (TB).

27 Jul 2020

Clinical trial shows CAR-T cell therapy can be used for treating Hodgkin lymphoma

CAR-T cell therapy, which attacks cancer cells using a person's reprogrammed immune cells, has been used to treat Hodgkin lymphoma with remarkable success for the first time, according to the results of an early phase clinical trial led by researchers at UNC Lineberger Comprehensive Cancer Center and Baylor College of Medicine in Houston.

24 Jul 2020