Proteomics, Metabolomics and Lipidomics News and Research

Latest Proteomics, Metabolomics and Lipidomics News and Research

Discovery of Glucocorticoid Receptor Multimerization Opens Path to Safer Therapies

Drugs to treat inflammatory and autoimmune diseases - such as asthma, psoriasis, rheumatoid arthritis or Chrousos syndrome - act mainly through the glucocorticoid receptor (GR).

28 Oct 2025

TRF1 Knockout Mice Exhibit Healthier Metabolic States Without Telomere Shortening

A new research paper was published in Volume 17, Issue 9 of Aging-US on September 17, 2025, titled "Depletion of the TRF1 telomere-binding protein leads to leaner mice with altered metabolic profiles."

28 Oct 2025

Rhizosphere Metabolites Play Key Role in Regulating the Distribution of Antibiotic Resistance Genes

Their study reveals that rhizosphere metabolites-substances secreted by plant roots-play a crucial role in regulating the distribution of manure-derived ARGs in both the soil and plant tissues.

27 Oct 2025

Enhancing Ovarian Cancer Treatment with Multi-Modal Immunotherapy Approach

Results of a study led by researchers at Roswell Park Comprehensive Cancer Center show that combining two types of immunotherapy - engineered T cells that secrete bispecific T cell engagers (BiTEs) and an immune checkpoint inhibitor - can alter the tumor microenvironment to launch a stronger attack against ovarian cancer and reduce the risk of relapse.

27 Oct 2025

First Chromosome-Scale Genome Assembly of Blackcurrant Reveals Drought Adaptation Strategies

Drought stress disrupts plant growth, metabolism, and reproduction, with devastating effects on crop productivity worldwide.

27 Oct 2025

Mitochondria and Lysosomes Orchestrate Metabolic States of Regulatory T Cells

Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the immune system.

27 Oct 2025

Understanding Interplay of Physiological Processes as the Brain Shifts from Wakefulness to Sleep

Findings from Mass General Brigham investigators highlight the intricate interplay of diverse physiological processes as the brain shifts from wakefulness to sleep.

27 Oct 2025

RNA-Based Molecular Switch Enhances Disease Resistance in Pears

In recent years, scientists have uncovered the remarkable regulatory power of long non-coding RNAs (lncRNAs) - RNA molecules once dismissed as "genetic dark matter."

24 Oct 2025

Disrupted Circadian Rhythms Alter Gene Activity in Alzheimer’s Disease

Alzheimer's disease is notorious for scrambling patients' daily rhythms. Restless nights with little sleep and increased napping during the day are early indicators of disease onset, while sundowning, or confusion later in the day, is typical for later stages of the disease.

24 Oct 2025

Hidden RNA Inside a Gene Solves Decades-Old Telomere Mystery in Roundworms

An international research team led by Hiroki Shibuya at RIKEN Center for Biosystems Dynamics Research (BDR) in Japan has solved a genetic mystery and revealed a previously unknown way that DNA can control what cells do.

24 Oct 2025

Study Shows Flatulence Gas Hydrogen is Crucial for Gut Health

Farts are causing a stink in the research world, but in a positive way.

24 Oct 2025

Breakthrough Cryo-EM Study Maps Herpes Replication Protein in New Detail

An international research team has successfully identified the initial high-resolution structures of the herpes simplex virus origin-binding protein (OBP), which is an essential element in viral DNA replication that has remained structurally uncharacterized for the past forty years.

24 Oct 2025

Scientists Reveal How Nanovaccines Boost the Immune Fight Against Aggressive Breast Cancers

Nanovaccines show promise in breast cancer therapy, enhancing immune activation and targeting cold tumors, particularly in challenging triple-negative cases.

24 Oct 2025

DNA Cassettes Enable Long-Lasting Antibody Production Directly Inside Patients

A multidisciplinary team of scientists led by The Wistar Institute, including Perelman School of Medicine at the University of Pennsylvania, AstraZeneca and Inovio Pharmaceuticals, published today in Nature Medicine a breakthrough in biologic antibody production that happens directly in human subjects in this encouraging first clinical trial of its kind.

23 Oct 2025

Research Pinpoints HMGN1 as Cause of Trisomy 21-Related Heart Abnormalities

Three copies of chromosome 21 causes Down syndrome (DS), and roughly half of children born each year in the United States with DS-approximately 2,600-also have congenital heart defects (CHDs).

23 Oct 2025

Mapping the Molecular Choreography of Nuclear Pore Transport

Nuclear pore complexes (NPCs) are tiny but sophisticated gatekeepers that control the flow of materials between a cell's nucleus and its cytoplasm by quickly selecting which molecules to transport across the nuclear membrane.

22 Oct 2025

Cracking the Code of T Cell Expansion Inside Tumors

The ability of immune cells-particularly CD8+ T cells-to launch a rapid burst of proliferation inside tumors is key to the success of modern day cancer immunotherapies.

22 Oct 2025

Croatian Scientists Rewrite the Story of Cell Division

Scientists at the Ruđer Bošković Institute (RBI) in Zagreb, Croatia, have discovered that the protein CENP-E, long believed to act as a motor dragging chromosomes into place during cell division, in fact plays a completely different role in chromosome movement.

22 Oct 2025

Disarming Cancer’s Droplet Hubs to Halt Tumor Growth

In a city, coworking hubs bring people and ideas together. Inside cancer cells, similar hubs form-but instead of fueling progress, they supercharge disease. That's what researchers at the Texas A&M University Health Science Center (Texas A&M Health) have discovered inside the cells of a rare and aggressive kidney cancer.

21 Oct 2025

Decoding the Genetic Network Behind Soybean Shade Tolerance

In intercropping systems, soybeans grown beneath tall maize plants experience severe shading that disrupts photosynthesis, weakens stems, and limits yield.

21 Oct 2025

Proteomics, Metabolomics and Lipidomics News and Research

Latest Proteomics, Metabolomics and Lipidomics News and Research

Discovery of Glucocorticoid Receptor Multimerization Opens Path to Safer Therapies

TRF1 Knockout Mice Exhibit Healthier Metabolic States Without Telomere Shortening

Rhizosphere Metabolites Play Key Role in Regulating the Distribution of Antibiotic Resistance Genes

Enhancing Ovarian Cancer Treatment with Multi-Modal Immunotherapy Approach

First Chromosome-Scale Genome Assembly of Blackcurrant Reveals Drought Adaptation Strategies

Mitochondria and Lysosomes Orchestrate Metabolic States of Regulatory T Cells

Understanding Interplay of Physiological Processes as the Brain Shifts from Wakefulness to Sleep

RNA-Based Molecular Switch Enhances Disease Resistance in Pears

Disrupted Circadian Rhythms Alter Gene Activity in Alzheimer’s Disease

Hidden RNA Inside a Gene Solves Decades-Old Telomere Mystery in Roundworms

Study Shows Flatulence Gas Hydrogen is Crucial for Gut Health

Breakthrough Cryo-EM Study Maps Herpes Replication Protein in New Detail

Scientists Reveal How Nanovaccines Boost the Immune Fight Against Aggressive Breast Cancers

DNA Cassettes Enable Long-Lasting Antibody Production Directly Inside Patients

Research Pinpoints HMGN1 as Cause of Trisomy 21-Related Heart Abnormalities

Mapping the Molecular Choreography of Nuclear Pore Transport

Cracking the Code of T Cell Expansion Inside Tumors

Croatian Scientists Rewrite the Story of Cell Division

Disarming Cancer’s Droplet Hubs to Halt Tumor Growth

Decoding the Genetic Network Behind Soybean Shade Tolerance

Omics eBook

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

Proteomics, Metabolomics and Lipidomics News and Research

Latest Proteomics, Metabolomics and Lipidomics News and Research

Omics eBook

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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