Proteomics, Metabolomics and Lipidomics News and Research

Latest Proteomics, Metabolomics and Lipidomics News and Research

Scientists Identify TRPM4 as Key Molecular Switch Controlling Intestinal Fluid Balance

Although constipation and diarrhea may seem like opposite problems, they both hinge on the same underlying issue: how much fluid moves into the gut. These common issues affect millions of people in the U.S. each year, yet scientists have not fully understood what regulates intestinal fluid balance.

12 Jan 2026

Scientists Discover Tug-of-War Mechanism Driving Bacteria Flagella Direction Switching

Scientists have uncovered a new explanation for how swimming bacteria change direction, providing fresh insight into one of biology's most intensively studied molecular machines.

12 Jan 2026

Population-Specific Proteomic Analysis Advances Precision Medicine for Type 2 Diabetes

Researchers have conducted the most comprehensive analysis to date linking plasma proteins to genetic variation in individuals from continental Africa.

9 Jan 2026

Deep Learning–Based Codon Optimization Framework Boosts Protein Expression in E. coli

By combining Transformer-based sequence modeling with a novel conditional probability strategy, the approach overcomes long-standing trade-offs between maximizing expression metrics and maintaining translational features critical for proper protein folding.

9 Jan 2026

Parallel Molecular Routes Ensure Accurate Centromere Specification During Cell Division

Despite the immense amount of genetic material present in each cell, around three billion base pairs in humans, this material needs to be accurately divided in two and allocated in equal quantities.

9 Jan 2026

Ancient WUS Genes and Expression Thresholds Shape Shoot Regeneration

Unlike animals, plants generate most organs after embryogenesis through stem cell–driven meristems, enabling lifelong growth and regeneration.

9 Jan 2026

Molecular Switch Found to Control Single-Celled to Multicellular Transitions

Scientists at Nagoya University in Japan have identified the genes that allow an organism to switch between living as single cells and forming multicellular structures.

8 Jan 2026

New Molecules Harness Cellular Recycling to Eliminate Cancer's Immune Shield IDO1

Cells have a remarkable housekeeping system: proteins that are no longer needed, defective, or potentially harmful are labeled with a molecular "tag" and dismantled in the cellular recycling machinery.

8 Jan 2026

Synthetic Biology and Metabolic Engineering Drive Microbial L-Tryptophan Biomanufacturing

This review synthesizes progress in pathway optimization, regulatory rewiring, and microbial cell factory design that has driven L-Trp titers to industrially relevant levels while enabling the biosynthesis of downstream products ranging from neurotransmitters and plant hormones to dyes and complex alkaloids.

8 Jan 2026

USU Researchers Discover CRISPR Cas12a3's Potential for Viral Protein Inhibition

Across all domains of life, immune defenses foil invading viruses by making it impossible for the viruses to replicate. Most known CRISPR systems target invading pathogens' DNA and chop it up to disable and modify genes, heading off infections at the (cellular) pass.

8 Jan 2026

Mitochondria Transfer Eases Chronic Nerve Pain

For millions living with nerve pain, even a light touch can feel unbearable. Scientists have long suspected that damaged nerve cells falter because their energy factories known as mitochondria don't function properly.

8 Jan 2026

Turning Human Fat into Insulin-Producing Organoids That Reverse Diabetes

By preserving fat tissue architecture, researchers created organoids that restore insulin function, paving the way for advancements in diabetes treatment.

8 Jan 2026

Identifying Molecules That Activate and Inhibit Key Protein Function

Researchers at Northwestern University have discovered a concealed molecular "control switch" within a protein that plays a crucial role in the body's ability to perceive taste, regulate blood sugar, and protect the gut.

7 Jan 2026

Microneedle Patches May Unlock Safer, Localized Cancer Immunotherapy

This review highlights the potential of natural polysaccharide microneedles in cancer immunotherapy, focusing on localized treatment and immune activation.

7 Jan 2026

Blocking Retinoic Acid Pathway Improves Dendritic Cell Anti-Tumor Function

Scientists at the Princeton University Branch of the Ludwig Institute for Cancer Research have identified novel mechanisms by which a metabolic derivative of vitamin A-all-trans retinoic acid-compromises both the body's normal anti-cancer immune response and, in a different context, the efficacy of a promising type of cancer vaccine.

6 Jan 2026

Hidden Molecular "Control Switch" Uncovered Inside TRPM5 Protein

Northwestern University scientists have uncovered a hidden molecular "control switch" inside a protein that helps the body sense taste, control blood sugar and defend the gut.

6 Jan 2026

Aging Alters a Common Set of RNA Splicing and Processing Genes Across Tissues

A new research paper featured as the cover of Volume 17, Issue 12 of Aging-US was published on December 22, 2025, titled "A combination of differential expression and network connectivity analyses identifies a common set of RNA splicing and processing genes altered with age across human tissues."

6 Jan 2026

Study Resolves Ancient Genome Duplication History of Flowering Plants

Angiosperms, also known as flowering plants, represent the most diverse group of seed plants, and their origin and evolution have long been a central question in plant evolutionary biology.

5 Jan 2026

Scientists Develop Noise Controller to Tame Random Cell Behavior

Why does cancer sometimes recur after chemotherapy? Why do some bacteria survive antibiotic treatment? In many cases, the answer appears to lie not in genetic differences, but in biological noise - random fluctuations in molecular activity that occur even among genetically identical cells.

5 Jan 2026

Interferon Response in Female Brains Linked to Alzheimer's Progression

More than seven million Americans have Alzheimer's disease, and two-thirds of them are women, according to the Alzheimer's Association. The O'Banion Lab at the Del Monte Institute for Neuroscience at the University of Rochester has long been studying this disease and is looking more closely at the differences between male and female brains.

30 Dec 2025

Proteomics, Metabolomics and Lipidomics News and Research

Latest Proteomics, Metabolomics and Lipidomics News and Research

Scientists Identify TRPM4 as Key Molecular Switch Controlling Intestinal Fluid Balance

Scientists Discover Tug-of-War Mechanism Driving Bacteria Flagella Direction Switching

Population-Specific Proteomic Analysis Advances Precision Medicine for Type 2 Diabetes

Deep Learning–Based Codon Optimization Framework Boosts Protein Expression in E. coli

Parallel Molecular Routes Ensure Accurate Centromere Specification During Cell Division

Ancient WUS Genes and Expression Thresholds Shape Shoot Regeneration

Molecular Switch Found to Control Single-Celled to Multicellular Transitions

New Molecules Harness Cellular Recycling to Eliminate Cancer's Immune Shield IDO1

Synthetic Biology and Metabolic Engineering Drive Microbial L-Tryptophan Biomanufacturing

USU Researchers Discover CRISPR Cas12a3's Potential for Viral Protein Inhibition

Mitochondria Transfer Eases Chronic Nerve Pain

Turning Human Fat into Insulin-Producing Organoids That Reverse Diabetes

Identifying Molecules That Activate and Inhibit Key Protein Function

Microneedle Patches May Unlock Safer, Localized Cancer Immunotherapy

Blocking Retinoic Acid Pathway Improves Dendritic Cell Anti-Tumor Function

Hidden Molecular "Control Switch" Uncovered Inside TRPM5 Protein

Aging Alters a Common Set of RNA Splicing and Processing Genes Across Tissues

Study Resolves Ancient Genome Duplication History of Flowering Plants

Scientists Develop Noise Controller to Tame Random Cell Behavior

Interferon Response in Female Brains Linked to Alzheimer's Progression

Omics eBook

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Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Proteomics, Metabolomics and Lipidomics News and Research

Latest Proteomics, Metabolomics and Lipidomics News and Research

Omics eBook

How Avatar Medical's 3D Technology Is Transforming How We Visualize the Human Body

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

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