Liver News and Research

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Integrated-Gut-Liver-on-a-Chip can Improve Understanding of Non-Alcoholic Fatty Liver Disease

A new chip that holds different cell types in tiny, interconnected chambers could allow scientists to better understand the physiological and disease interactions between organs.

10 Apr 2023

UDCA Use Associated with Reduced Odds of COVID-19

SARS-CoV-2, the virus that causes COVID-19, attaches to a cellular receptor called angiotensin-converting enzyme 2 (ACE2), and activation of the farnesoid X receptor increases ACE2 expression.

6 Apr 2023

Designing a Lipid Nanoparticle to Safely Deliver mRNA to the Pancreas

Therapeutics that use mRNA-;like some of the COVID-19 vaccines-;have enormous potential for the prevention and treatment of many diseases.

4 Apr 2023

New, Effective Method can Make Rare Cell Types and Disease Patterns Visible in Tissue

The human body contains more than 30 trillion cells. Until recently, the sheer number of cells in the organism meant that approaches to understanding human diseases and developmental processes based on the analysis of single cells were a futuristic vision.

3 Apr 2023

New nanoparticles can deliver mRNA encoding CRISPR/Cas9 components to the lungs

Engineers at MIT and the University of Massachusetts Medical School have designed a new type of nanoparticle that can be administered to the lungs, where it can deliver messenger RNA encoding useful proteins.

31 Mar 2023

Single monoclonal antibody infusion can strengthen the body's fight against yellow fever

New research from Oregon Health & Science University and collaborators indicates lab-made antibodies may be able to cure people infected with yellow fever, a virus for which there is no treatment.

30 Mar 2023

Cocklebur fruit shows potential to protect the skin and help enhance collagen production

The fruit of the cocklebur plant, which grows worldwide and is often considered a noxious weed, has antioxidant and anti-inflammatory components that could make it useful as a skin protectant, according to new research.

29 Mar 2023

Additional therapeutic maneuver may be needed to stop some metastasized tumors Cancer That...

Cancer that has spread to areas like the lungs can apply the brakes to a natural pathway that should recruit killer T cells directly to where it has metastasized, scientists report.

29 Mar 2023

3D cell culture system may be a valuable tool for assessing drug efficacy on tumor growth

Fibroblasts build and maintain the extracellular matrix, or physical scaffolding for cells, in the connective tissues within the body.

29 Mar 2023

New compound may offer a way to prevent serious C. diff infections

Each year, about 500,000 people in the U.S. deal with gastrointestinal infections from Clostridioides difficile (C. diff), and more than 20,000 die from these infections.

27 Mar 2023

Single mechanosensitive protein shown to contribute to fibrosis in multiple organs

Researchers from Kyushu University have found how a single mechanosensitive protein induces the process that thickens and scars tissue, known as fibrosis. The protein, called VGLL3, was shown to contribute to fibrosis in multiple organs.

23 Mar 2023

Curcumin could enhance ovarian cancer treatments

A pharmacology researcher at New York Institute of Technology College of Osteopathic Medicine (NYITCOM) has co-authored a new study that makes a strong case for why a golden spice commonly found in curry could enhance ovarian cancer treatments.

23 Mar 2023

Identifying biomarkers that help treat fatty liver patients with a personalized diet

Recent research from the University of Jyväskylä contrasted the gut microbiota and gut-derived metabolites of healthy controls and fatty liver patients. The findings show that some microbial metabolites are linked to liver fat content.

23 Mar 2023

Previously unknown genetic causes of three rare conditions discovered

Using a new computational approach they developed to analyze large genetic datasets from rare disease cohorts, researchers at the Icahn School of Medicine at Mount Sinai and colleagues have discovered previously unknown genetic causes of three rare conditions: primary lymphedema (characterized by tissue swelling), thoracic aortic aneurysm disease, and congenital deafness.

20 Mar 2023

Researchers discover previously unknown genetic causes of three rare conditions

17 Mar 2023

Highlighting a potential sex‐specific precision immunotherapy strategy

Immunotherapy is an effective form of treatment for various types of cancer. However, its effect on pancreatic cancer is restricted and varies between men and women. Karolinska Institutet scientists have observed a possible explanation for this gender difference.

17 Mar 2023

Bile salt hydrolase cocktails may offer a new approach to inhibit C. diff colonization

Not all probiotics are created equal. In a new study, researchers found that certain enzymes within a class known as bile salt hydrolases (BSHs) can restrict Clostridioides difficile (C. diff.) colonization by both altering existing bile acids and by creating a new class of bile acids within the gut's microbial environment.

14 Mar 2023

Study investigates schizophrenia risk across African ancestry

Researchers have identified two previously unknown genes linked to schizophrenia and newly implicated a third gene as carrying risk for both schizophrenia and autism. Led by the Icahn School of Medicine at Mount Sinai, the multi-center study further demonstrated that the schizophrenia risk conferred by these rare damaging variants is conserved across ethnicities. The study may also point to new therapeutics.

14 Mar 2023

Chemical compound found in common tropical plant helps kill cancer cells

A scientific instrument at the Department of Energy's Oak Ridge National Laboratory could help create a noninvasive cancer treatment derived from a common tropical plant.

13 Mar 2023

Liver-produced hormone protects mice against the harmful effects of intoxication

A shot of a liver-produced hormone called FGF21 sobered up mice that had passed out from alcohol, allowing them to regain consciousness and coordination much faster than those that didn't receive this treatment, UT Southwestern researchers report in a new study.

8 Mar 2023

Liver News and Research

Integrated-Gut-Liver-on-a-Chip can Improve Understanding of Non-Alcoholic Fatty Liver Disease

UDCA Use Associated with Reduced Odds of COVID-19

Designing a Lipid Nanoparticle to Safely Deliver mRNA to the Pancreas

New, Effective Method can Make Rare Cell Types and Disease Patterns Visible in Tissue

New nanoparticles can deliver mRNA encoding CRISPR/Cas9 components to the lungs

Single monoclonal antibody infusion can strengthen the body's fight against yellow fever

Cocklebur fruit shows potential to protect the skin and help enhance collagen production

Additional therapeutic maneuver may be needed to stop some metastasized tumors Cancer That...

3D cell culture system may be a valuable tool for assessing drug efficacy on tumor growth

New compound may offer a way to prevent serious C. diff infections

Single mechanosensitive protein shown to contribute to fibrosis in multiple organs

Curcumin could enhance ovarian cancer treatments

Identifying biomarkers that help treat fatty liver patients with a personalized diet

Previously unknown genetic causes of three rare conditions discovered

Researchers discover previously unknown genetic causes of three rare conditions

Highlighting a potential sex‐specific precision immunotherapy strategy

Bile salt hydrolase cocktails may offer a new approach to inhibit C. diff colonization

Study investigates schizophrenia risk across African ancestry

Chemical compound found in common tropical plant helps kill cancer cells

Liver-produced hormone protects mice against the harmful effects of intoxication

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