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HKU researchers develop new drug discovery strategy targeting membrane proteins on live cells

A research team led by Dr Xiaoyu LI from the Research Division for Chemistry, Faculty of Science, in collaboration with Professor Yizhou LI from School of Pharmaceutical Sciences, Chongqing University and Professor Yan CAO from School of Pharmacy, Second Military Medical University in Shanghai has developed a new drug discovery method targeting membrane proteins on live cells.

29 Dec 2020

Triple drug combination keeps people with metastatic colon cancer disease free for longer time

Researchers from SWOG Cancer Research Network, a cancer clinical trials group funded by the National Cancer Institute (NCI), part of the National Institutes of Health, have shown that a triple drug combination - of irinotecan, cetuximab, and vemurafenib - is a more powerful tumor fighter and keeps people with metastatic colon cancer disease free for a significantly longer period of time compared with patients treated with irinotecan and cetuximab.

24 Dec 2020

Study reveals lower transfer of protective SARS-CoV-2 antibodies via the placenta

Recent analyses indicate that pregnant women and newborns may face elevated risks of developing more severe cases of COVID-19 following SARS-CoV-2 infection.

24 Dec 2020

Researchers discover protein that may trigger lung scarring

Systemic sclerosis is an autoimmune disease associated with inflammation and fibrosis, or scarring, that affects organs including the skin, heart, kidney and lungs.

18 Dec 2020

Researchers discover genetic variants of host proteins involved in SARS-CoV-2 infection

Like all viruses, the novel coronavirus is dependent on help from the human host cell. Proteins are the functional units of the cell and enable the virus to enter the host cell or help the virus to replicate.

17 Dec 2020

Water intake may effectively mitigate obesity and metabolic syndrome

Researchers at the University of Colorado Anschutz Medical Campus have discovered that fructose stimulates the release of vasopressin, a hormone linked to obesity and diabetes.

16 Dec 2020

Tumor's stiff-arm tactic restricts the effectiveness of checkpoint inhibitors

In a paper just published in the Journal for the Immunotherapy of Cancer (doi:10.1136/jitc-2020-001712), Dr. Herbert, Head of Discovery at InsideOutBio, asks whether cancer cells stiff-arm immune cells just like rugby players push off defenders from the other team.

16 Dec 2020

Molecular markers in the blood can predict severe COVID-19 outcomes

Molecular markers in the blood shown to be predictive of severe COVID-19 outcomes resulting from SARS-CoV-2 coronavirus infection have been identified in a study by a Chinese research team.

15 Dec 2020

CTC dynamics related to overall survival in patients with metastatic breast cancer

Early circulating tumor cell dynamics were associated with overall survival in patients with metastatic breast cancer, according to a meta-analysis presented at the 2020 San Antonio Breast Cancer Symposium, held Dec. 8-11.

10 Dec 2020

Researchers identify key molecular processes used by coronaviruses to survive

When a coronavirus--including SARS-CoV-2, which causes COVID-19--infects someone, it hijacks the person's cells, co-opting their molecular machinery for its own survival and spread.

9 Dec 2020

Researchers discover molecular mechanism of plant immune receptors

In a recent study, Alexander von Humboldt Professor Jijie Chai at the University of Cologne and his team together with MPIPZ researchers have succeeded for the first time in reconstructing the sequence of molecular events that activate an inactive plant immune receptor and thus mediate the death of the host cell.

8 Dec 2020

Study: CAR T cell therapy is a safe, effective therapy for high-risk large B-cell lymphoma

A study led by researchers at The University of Texas MD Anderson Cancer Center found that axi-cel, an autologous anti-CD19 chimeric antigen receptor (CAR) T cell therapy, is a safe and effective first-line therapy for patients with high-risk large B-cell lymphoma (LBCL), a group with an urgent need for new and effective treatments.

8 Dec 2020

Mice infused with CD5-deleted CAR T cells showed significant reduction in tumor size

Knocking out a protein known to stifle T cell activation on CAR T cells using the CRISPR/Cas9 technology enhanced the engineered T cells' ability to eliminate blood cancers, according to new preclinical data from researchers in the Perelman School of Medicine at the University of Pennsylvania and Penn's Abramson Cancer Center.

8 Dec 2020

Researchers target pathogenic T cells that could lead to new immunotherapy treatments

According to a new study, a novel T cell genetically engineered by scientists from The University of Arizona Health Sciences can target and attack pathogenic T cells that are responsible for causing Type 1 diabetes. These latest findings may result in new immunotherapy therapies.

7 Dec 2020

CAR T-cell therapy reduced cancer cells in patients with advanced non-Hodgkin lymphoma

A CAR T-cell therapy known as axicabtagene ciloleucel (axi-cel) drove cancer cells to undetectable levels in nearly 80% of patients with advanced non-Hodgkin lymphoma (NHL) in a phase 2 clinical trial, Dana-Farber Cancer Institute investigators report at the virtual 62nd American Society of Hematology (ASH) Annual Meeting.

7 Dec 2020

Study reveals how bean plants initiate anti-herbivore defenses

For a caterpillar, a green leaf can make a nice meal. But to the plant itself, it's an attack. And very hungry caterpillars can do a lot of damage as they eat their way through life.

7 Dec 2020

Researchers determine role of NLRP1 protein in detecting the common cold virus

The role of a protein in detecting the common cold virus and kickstarting an immune response to fight infection has been uncovered by a team of scientists from Nanyang Technological University, Singapore (NTU Singapore), the Agency for Science, Technology and Research (A*STAR) and the National University of Singapore.

From Nanyang Technological University Singapore (NTU Singapore) 3 Dec 2020

Environmental and exogenous compounds can interact with therapeutic drugs, shows study

According to scientific estimations, humans are exposed to at least 10,000 to 100,000 environmental and exogenous compounds in an individual lifetime, which are mainly absorbed through our dietary.

3 Dec 2020

Scientists identify key biological switch used in plant defense against animal attack

For decades, scientists have known that plants protect themselves from the devastation of hungry caterpillars and other plant-munching animals through sophisticated response systems, the product of millions of years of evolution.

From UC San Diego 25 Nov 2020

First functional analysis of cytokine IL-15L using rainbow trout

The cytokine family including interleukin-2 and -15 (IL-2 and IL-15) started out in a primitive vertebrate species with three related cytokines IL-2, IL-15, and IL-15-like (IL-15L), all sharing binding capacity for receptor chain IL-15Rα. IL-15L was conserved in fishes, reptiles, and some mammals but lost in humans and mice.

23 Nov 2020

Receptor News and Research

HKU researchers develop new drug discovery strategy targeting membrane proteins on live cells

Triple drug combination keeps people with metastatic colon cancer disease free for longer time

Study reveals lower transfer of protective SARS-CoV-2 antibodies via the placenta

Researchers discover protein that may trigger lung scarring

Researchers discover genetic variants of host proteins involved in SARS-CoV-2 infection

Water intake may effectively mitigate obesity and metabolic syndrome

Tumor's stiff-arm tactic restricts the effectiveness of checkpoint inhibitors

Molecular markers in the blood can predict severe COVID-19 outcomes

CTC dynamics related to overall survival in patients with metastatic breast cancer

Researchers identify key molecular processes used by coronaviruses to survive

Researchers discover molecular mechanism of plant immune receptors

Study: CAR T cell therapy is a safe, effective therapy for high-risk large B-cell lymphoma

Mice infused with CD5-deleted CAR T cells showed significant reduction in tumor size

Researchers target pathogenic T cells that could lead to new immunotherapy treatments

CAR T-cell therapy reduced cancer cells in patients with advanced non-Hodgkin lymphoma

Study reveals how bean plants initiate anti-herbivore defenses

Researchers determine role of NLRP1 protein in detecting the common cold virus

Environmental and exogenous compounds can interact with therapeutic drugs, shows study

Scientists identify key biological switch used in plant defense against animal attack

First functional analysis of cytokine IL-15L using rainbow trout

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