Signaling Pathway News and Research

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Study analyzes the role of heart cell protein as a potential therapeutic for heart failure

Recent research identified that a protein involved in regulating calcium signaling within heart cells can play a vital role in the prevention of chronic heart failure.

From The University of Utah 29 Jul 2021

New method to control the complex communication network of cells

A study has proposed a new method for developing novel drugs based on the suppression of tyrosine kinase enzymes.

21 Jun 2021

A new treatment approach against SARS-CoV-2

Scientists have come up with a new method to treat SARS-CoV-2 infection by fixing the cell damage instead of fighting the virus directly.

21 Jun 2021

Genetically engineering NK cells can target and kill glioblastoma stem cells

Preclinical research from The University of Texas MD Anderson Cancer Center finds that although glioblastoma stem cells (GSCs) can be targeted by natural killer (NK) cells, they are able to evade immune attack by releasing the TFG-β signaling protein, which blocks NK cell activity.

18 Jun 2021

Presence of certain stem cells correlates with non-genetic resistance mechanisms to cancer drugs

Cancer cells can develop resistance to therapy through both genetic and non-genetic mechanisms. But it is unclear how and why one of these routes to resistance prevails.

18 Jun 2021

Understanding molecular determinants of liver cancer in patients with Indigenous American ancestry

Oncotarget published "Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry" which reported that contrasting with this pattern, the age structure of HCC in Andean people displays a bimodal distribution with half of the patients developing HCC in adolescence and early adulthood.

2 Jun 2021

Exploring the Genetic effects of Chernobyl Radiation

In this interview, AZoLifeSciences speaks to researchers from the National Cancer Institute about their latest research that investigated the genetic effects of Chernobyl radiation.

From National Cancer Institute (NCI) 13 May 2021

Cutting-edge genomic tools used to investigate health effects of Chernobyl radiation exposure

In two landmark studies, researchers have used cutting-edge genomic tools to investigate the potential health effects of exposure to ionizing radiation, a known carcinogen, from the 1986 accident at the Chernobyl nuclear power plant in northern Ukraine.

From National Cancer Institute (NCI) 23 Apr 2021

Scientists discover mutations that make cancer resistant to KRAS-targeted therapies

A gene called KRAS is one of the most commonly mutated genes in all human cancers, and targeted drugs that inhibit the protein expressed by mutated KRAS have shown promising results in clinical trials, with potential approvals by the U.S. Food and Drug Administration anticipated later this year.

7 Apr 2021

Novel agonistic effect of polyphenol compound could treat amyloidosis, other metabolic disorders

Reportedly, Curcumin has several physiological activities, which include anti-inflammatory, anti-oxidation, anti-amyloid, and anti-cancer properties.

1 Mar 2021

New signaling pathway prevents the overproduction of RNA-protein complexes

Neurodegenerative diseases, such as various forms of senile dementia or amyotrophic lateral sclerosis (ALS), have one thing in common: large amounts of certain RNA-protein complexes (snRNPs) are produced and deposited in the nerve cells of those affected - and this hinders the function of the cells.

26 Feb 2021

Researchers identify three genes regulating stemness of gastric tissue stem cells

Tissue stem cells can self-renew and differentiate, supplying cells necessary for tissues at various developmental stages.

9 Feb 2021

Scientists implicate disruption in prenatal neurogenesis in the development of autism

A new study of autism risk genes by UC San Francisco and UC Berkeley scientists implicates disruption in prenatal neurogenesis - a process in which specialized "progenitor" cells give rise to new brain cells - in the development of autism spectrum disorders (ASDs).

9 Feb 2021

Researchers identify key molecule involved in immune regulation

The majority of the molecules in human bodies support the immune system to keep individuals healthy but they do so without reacting excessively, as this may otherwise drive the immune cells to cause problems, like autoimmune disorders.

29 Jan 2021

Scientists identify the sensor in human lungs that detects SARS-CoV-2

Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified the sensor in human lungs that detects SARS-CoV-2 and signals that it's time to mount an antiviral response.

13 Jan 2021

Protein phosphatase inhibition could contribute to the treatment of cancer, other diseases

The abundant presence of an enzyme known as low molecular weight protein tyrosine phosphatase (LMWPTP) in tumor cells has long been considered an indicator of cancer aggressiveness and metastatic potential.

13 Jan 2021

Combination method can boost immunotherapy for breast cancer

According to a new study performed by scientists from the University of North Carolina, stimulating an immune signaling pathway, which is best known for combating bacterial and viral infections, can increase the potential of genetically engineered T cells to remove breast cancer in mice.

4 Jan 2021

Study: Fungi have proteins that allow them to sense consumable things

According to a new study, the same proteins responsible for enabling human senses, like smell, also enable some fungi to sense things they can consume.

17 Dec 2020

Molecular markers in the blood can predict severe COVID-19 outcomes

Molecular markers in the blood shown to be predictive of severe COVID-19 outcomes resulting from SARS-CoV-2 coronavirus infection have been identified in a study by a Chinese research team.

15 Dec 2020

New combination therapy could be effective in treating aggressive cancers with common mutations

Scientists have long known that therapies that target the cancer-driving MAPK pathway are only effective in a handful of cancers with specific mutations in a cancer gene called BRAF, and these cancers that initially respond to the therapy often end up developing resistance to the treatment, resulting in relapse for many patients.