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Modified Nucleotides Boost saRNA Vaccine Efficacy and Protection Against SARS-CoV-2

Modified nucleotides like m5C in saRNA enhance vaccine efficacy, stability, and reduce inflammation, offering a promising approach for SARS-CoV-2 protection.

18 Sep 2024

Beta Cells Alone Can Maintain Glycemic Balance Without Other Pancreatic Cells

Our glycemic balance is based on the ability of the pancreatic beta cells to detect glucose and secrete insulin to maintain our blood sugar levels.

4 Sep 2024

High-Speed Atomic Force Microscopy Reveals Cofilin Binding Patterns in Actin Filaments

Researchers at Kanazawa University report in eLife on deciphering the actin structure-dependent preferential cooperative binding of cofilin.

29 Aug 2024

A Breakthrough in RNA Therapy for Heart and Nervous System Diseases

Researchers at the University of California San Diego have developed new techniques to sculpt RNA molecules into circles that may result in more potent and long-lasting treatments.

27 Aug 2024

Nile Grass Rats Become New Model for CRISPR Genome Editing

A team of researchers at Michigan State University has discovered a set of methods that enabled the first successful CRISPR-based genome editing in Nile grass rats.

27 Aug 2024

New Human Intestinal Immuno-Organoids Reveal Insights into Immune Cell Dynamics and Cancer Immunotherapy

Research on intestinal immuno-organoids reveals their potential in modeling immune interactions and studying intestinal diseases linked to cancer therapies.

26 Aug 2024

Efficient and Reproducible BBB Modeling for Drug Development

Scientists at Southwest Research Institute have developed a new screening method to identify drug formulations that can penetrate the blood-brain barrier (BBB), to facilitate treatment of brain diseases and conditions.

23 Aug 2024

Novel Drug Targets in Gardnerella Vaginalis: A Bioinformatics Approach to Combat Bacterial Vaginosis

A computational approach to identify proteins in G. vaginalis that could be potential drug targets.

20 Aug 2024

New Imaging Technique Offers Clearer View of Brain Function

Researchers have developed a new two-photon fluorescence microscope that captures high-speed images of neural activity at cellular resolution. By imaging much faster and with less harm to brain tissue than traditional two-photon microscopy, the new approach could provide a clearer view of how neurons communicate in real time, leading to new insights into brain function and neurological diseases.

16 Aug 2024

From CRISPR-Cas to Fanzor system: New frontiers in gene editing

The features of various CRISPR-Cas systems, including CRISPR-associated transposons (CASTs) and the eukaryotic equivalent of CRISPR-Cas systems, Fanzor systems.

9 Aug 2024

Innovative Nanosensing Method Promises Safer Gene Therapy with Improved AAV Vector Quality

Over the past few decades, there has been remarkable progress in genetic manipulation technologies, bringing us closer to the point where genes can be modified in vivo.

2 Aug 2024

The Role of Chemical Proteomics in Understanding Small Molecule-Protein Interactions

The various chemical proteomics methods with relevant examples.

31 Jul 2024

Effective Plasmid DNA Delivery Achieved with Zwitterionic Polymer Complex

Researchers from Tokyo Metropolitan University have created a new drug delivering molecule, a zwitterionic polymer complex that can help get plasmid DNA inside cells when injected into skeletal muscle, a crucial step in the expression of therapeutic RNA and proteins. The new compound effectively bound to plasmid DNA without affecting its structure. Injected into mouse muscles, the team observed widespread gene expression, promising applications to treatments of serious muscle diseases.

29 Jul 2024

Antisense Therapy Shows Promise Against Parkinson's

Parkinson's disease (PD), as well as many other neurodegenerative disorders, has shown a link between the abnormal aggregation of a protein called α-synuclein (aSyn) and neuronal death. These aggregates, known as Lewy bodies and Lewy neurites depending on their subcellular localization, can spread by continuously causing normal endogenous aSyn to misfold.

26 Jul 2024

in vivo News and Research

Modified Nucleotides Boost saRNA Vaccine Efficacy and Protection Against SARS-CoV-2

Beta Cells Alone Can Maintain Glycemic Balance Without Other Pancreatic Cells

High-Speed Atomic Force Microscopy Reveals Cofilin Binding Patterns in Actin Filaments

A Breakthrough in RNA Therapy for Heart and Nervous System Diseases

Nile Grass Rats Become New Model for CRISPR Genome Editing

New Human Intestinal Immuno-Organoids Reveal Insights into Immune Cell Dynamics and Cancer Immunotherapy

Efficient and Reproducible BBB Modeling for Drug Development

Novel Drug Targets in Gardnerella Vaginalis: A Bioinformatics Approach to Combat Bacterial Vaginosis

New Imaging Technique Offers Clearer View of Brain Function

From CRISPR-Cas to Fanzor system: New frontiers in gene editing

Innovative Nanosensing Method Promises Safer Gene Therapy with Improved AAV Vector Quality

The Role of Chemical Proteomics in Understanding Small Molecule-Protein Interactions

Effective Plasmid DNA Delivery Achieved with Zwitterionic Polymer Complex

Antisense Therapy Shows Promise Against Parkinson's

Study Identifies Microproteins as Key Source of Tumor-Specific Antigens in Liver Cancer

New Model Reveals Interplay Between Circadian Rhythms and Sleep-Wake Cycles in Gene Expression

All-RNA Gene Writing Method Paves Way for Precise Gene Editing in Human Cells

Advancing the Understanding of Circadian Regulation with Melanopsin DNA Aptamers

Liver-on-Chips: Innovations, Applications, and Challenges in Drug Development

New Insights into ILC2 Development Could Lead to Innovative Therapies for Allergic Diseases

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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