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Breakthrough 3D Vascular Sheet Mimics Atherosclerosis for High-Throughput Drug Screening

A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, University of Alabama at Birmingham researchers report in the journal Biomaterials.

16 Jan 2024

Novel Amino Acid Nanoparticles Offer Hope for Fighting Multi-Drug Resistant Cancers

Amino acids, such as tyrosine and tryptophan, are the fundamental building blocks that make up proteins.

9 Jan 2024

Breakthrough in Synthetic Biology: Researchers Build Artificial CO2-Fixing Pathway

Synthetic biology offers the opportunity to build biochemical pathways for the capture and conversion of carbon dioxide (CO2).

3 Jan 2024

Mettl3 Drives Powerful Immune Defense of CD8 T Cells

This study is led by Dr. Shuyang Yu (College of Biological Sciences, China Agricultural University), Dr. Jingyu Xu (The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University) and Dr. Xuguang Du (College of Biological Sciences, China Agricultural University) and illustrated the key role of Mettl3 in CD8 T cell response during acute infection model.

2 Jan 2024

AI-Powered Drug Breakthrough: Insilico Unveils Potent FGFR2/3 Inhibitor for Solid Tumors

Insilico Medicine, a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM8001, a novel molecule targeting FGFR2/3 for the treatment of tissue-agnostic solid tumors bringing the total number of PCCs nominated in 2023 to six.

29 Dec 2023

Xeno-Free Monkey PSC Culture System Enables Deriving, Tracking, and Differentiating Stem Cells

Non-human primates (NHPs) have a high degree of similarity to humans compared to other animal models.

26 Dec 2023

Novel Technique for High-Resolution Spectral Analysis of the Eye Fundus

Many ocular diseases involve changes in the structure and function of different regions of the back of the eye, also known as the "eye fundus."

18 Dec 2023

Presage Biosciences and AstraZeneca Partner to Advance Immuno-Oncology Research for Head and Neck Cancer

Presage Biosciences, a pioneering translational oncology company whose mission is to use CIVO and spatial molecular profiling to understand the complexity of drug response in the tumor microenvironment (TME), has entered into an agreement with AstraZeneca, a global biopharmaceutical company.

1 Dec 2023

New Irreversible Inhibitor Overcomes Drug Resistance in Cancer Cells

The concept of irreversible inhibitors binding permanently to a target protein has garnered growing interest for potential applications in drug development.

30 Nov 2023

Novel Biosensors Uncover Brain Activity

Researchers have employed novel biosensors to uncover neuropeptide activity in the brain, introducing innovative tools for examining the release, function, and regulation of these vital signaling molecules in vivo.

17 Nov 2023

Exploring the Probiotic Potential of Fungi in Food Production

As detailed in a recent study, two fungi employed in food production exhibit promising probiotic properties that could help alleviate gut inflammation. This research sheds light on a potential avenue for creating novel probiotics.

27 Oct 2023

Pusan National University Scientists Explore OsMATL2 Gene as a Candidate for Haploid Induction in Rice

Double haploid technology can dramatically accelerate crop breeding with specifically chosen genetic traits.

13 Sep 2023

The Intriguing Phenomenon of Cellular Reprogramming

A fascinating phenomenon of cellular reprogramming in developed adult organs has been revealed by researchers, providing insight into a brand-new process of adaptive development.

12 Sep 2023

Study Reports High-Resolution Structures of CAF-1

Since the passage of the DNA replication fork destroys nucleosomes on the DNA, chromatin inheritance during cell division requires the replication of DNA and the assembling of nucleosomes onto the duplicated DNA.

28 Aug 2023

Single Injection of CRISPR Gene-Editing Treatment Safely Removes SIV From Non-Human Primates

A single injection of a novel CRISPR gene-editing treatment safely and efficiently removes SIV – a virus related to the AIDS-causing agent HIV – from the genomes of non-human primates, scientists at the Lewis Katz School of Medicine at Temple University now report.

17 Aug 2023

Novel Matrix Supports Co-Culture of Endometrial Cells

Researchers have developed a synthetic extracellular matrix (ECM) that can facilitate the development of a miniature endometrium in a dish for at least two weeks.

14 Aug 2023

New Mechanism Regulating Tumor Growth in the Skeleton Identified

Tumor cells are known to be fickle sleeper agents, often lying dormant in distant tissues for years before reactivating and forming metastasis. Numerous factors have been studied to understand why the activation occurs, from cells and molecules to other components in the so-called tissue microenvironment.

11 Aug 2023

Do Host Social Interactions Influence Gut Bacteria Evolution?

A recent study demonstrates how host social interactions can have a significant influence on the development of gut bacteria in the gut microbiome. The study, carried out by a group of researchers from Instituto Gulbenkian de Ciência, sought to investigate the impact of host-to-host bacterial transmission on Escherichia coli (E. coli) evolution in mammalian guts.

3 Aug 2023

New Proof-of-Concept Model for Delivering Gene Editing Tools to Treat Blood Disorders

In a step forward in the development of genetic medicines, researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders, allowing for the modification of diseased blood cells directly within the body.

28 Jul 2023

New Collaboration Aims to Advance Cancer Therapies Against Previously Undruggable Targets

The University of Texas MD Anderson Cancer Center and Nexo Therapeutics today announced a multi-year strategic collaboration that aligns the innovative technology and capabilities of each organization at the earliest stages of drug discovery and development to rapidly advance impactful new cancer therapies against previously undruggable targets.

26 Jul 2023