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Triple-negative breast cancer's ecosystem reveals potential therapeutic targets

Researchers from the Garvan Institute of Medical Research have uncovered four new subtypes of cells within triple-negative breast cancer, which contain promising new therapeutic targets for the aggressive disease.

13 Aug 2020

Study indicates a powerful treatment for pulmonary fibrosis

A pre-clinical study led by scientists at Cincinnati Children's demonstrates that in mice the drug barasertib reverses the activation of fibroblasts that cause dangerous scar tissue to build up in the lungs of people with idiopathic pulmonary fibrosis (IPF).

7 Aug 2020

Newly discovered 'mutation fog' linked to normal DNA repair process

Hypermutation is an unusual occurence that can lead to many nearby mutations at once, severely damaging our genetic material and potentially causing cancer.

5 Aug 2020

New method reveals the dynamics of cell development and gene activity

Studies on cellular dynamics are vital to interpret the development of cells and the progression of various diseases.

5 Aug 2020

Researchers identify phosphoprotein biomarkers to guide cancer therapy

Precision medicine in cancer treatment uses genetic changes in the cancer cells to select the best therapies for individual patients.

29 Jul 2020

Deep learning algorithm can infer molecular alterations in cancer from histology images

Researchers at the University of Chicago Medicine Comprehensive Cancer Center, working with colleagues in Europe, created a deep learning algorithm that can infer molecular alterations directly from routine histology images across multiple common tumor types.

29 Jul 2020

Novel label-free imaging method can differentiate between quiescent and activated T cells

T cells are the immune soldiers at the frontlines of the battle with infiltrating pathogens that seek to cause disease. A new study published in Nature Biomedical Engineering describes a novel label-free imaging technique that can differentiate active T cells from those off duty.

28 Jul 2020

New approach is more effective in treating certain blood cancers

Some of the most promising advances in cancer treatment have centered on immunotherapies that rev up a patient's immune system to attack cancer.

24 Jul 2020

Researchers recreate pancreatic tissue 'in vitro' using 3D cell culture technique

Pancreatic cancer is a life-threatening disease with very poor survival rates in patients, and--despite various efforts--its treatment remains challenging.

23 Jul 2020

Fasting-mimicking diet combined with hormone therapy has potential to treat breast cancer

A USC-led team of scientists has found that a fasting-mimicking diet combined with hormone therapy has the potential to help treat breast cancer, according to newly published animal studies and small clinical trials in humans.

22 Jul 2020

Study explores the genetic and molecular basis of PD-L2 regulation

In immune-related disorders, therapy often involves identifying the molecules responsible for immune dysregulation and targeting them using drugs.

22 Jul 2020

Josep Carreras Institute creates spin-off to develop CAR-T based therapies for leukemia

The Josep Carreras Leukaemia Research Institute, a public centre pertaining to the Generalitat de Catalunya's (Government of Catalonia) CERCA network, has created the OneChain Immunotherapeutics spin-off, the aim of which is to develop new immuno-oncological therapeutic tools with various preclinical candidates, based on CAR-T technology for different tumors, such as cortical T-cell acute lymphoblastic leukemia (coT-ALL), a rare subtype of leukemia that mainly affects children, and which has a poor prognosis.

21 Jul 2020

Novel nano drug candidate kills triple negative breast cancer cells

Researchers at the University of Arkansas have developed a new nano drug candidate that kills triple negative breast cancer cells.

21 Jul 2020

Researchers estimate the cost-effectiveness and health impact of BRCA testing

Screening entire populations for breast and ovarian cancer gene mutations could prevent millions more breast and ovarian cancer cases across the world compared to current clinical practice, according to an international study led by Queen Mary University of London.

20 Jul 2020

Retinoic acid is the key to produce healthy offspring from testicular tissue transplantation

One in fifty births in Japan are said to be through in vitro fertilization, and many couples remain unable to conceive for reasons unknown. Infertility is also an undesired side-effect of lifesaving cancer treatment in childhood.

17 Jul 2020

New, promising CAR T cell therapy results in exceptional patient recovery

In a clinical trial evaluating a novel immunotherapy option for cancer treatment, a child with rhabdomyosarcoma, a form of muscle cancer, that had spread to the bone marrow, showed no detectable cancer following treatment with chimeric antigen receptor (CAR) T cells that were engineered to target the HER2 protein on the surface of cancerthe cells.

16 Jul 2020

Researchers develop novel and promising approach for treatment of lung cancer

A new and promising approach for treatment of lung cancer has been developed by researchers at Lund University. The treatment combines a novel surgical approach with smart nanoparticles to specifically target lung tumors. The new study has been published in the July issue of Advanced Therapeutics.

16 Jul 2020

New study can help develop novel drugs for prostate cancer

The androgen receptor is considered the main driver of the growth and initiation of prostate cancer, which is known to be the second-leading cause of death in men.

15 Jul 2020

Fewer but larger doses of radiotherapy are safe for patients with early breast cancer

A lower total dose of radiotherapy delivered in fewer but larger doses is as safe in the long term as breast cancer radiotherapy courses giving multiple small doses, according to the final results of a 10-year study.