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Study reveals mechanism by which ibuprofen prevents RAC1B alternative splicing in colorectal cells

Oncotarget published "Ibuprofen disrupts a WNK1/GSK3β/SRPK1 protein complex required for expression of tumor-related splicing variant RAC1B in colorectal cells" which reported that although the molecular mechanism behind the antitumor properties of NSAIDs has been largely attributed to inhibition of cyclooxygenases , several studies have shown that the chemopreventive properties of ibuprofen also involve multiple COX-independent effects.

23 Mar 2021

New highly sensitive RNA detection method advances in situ transcriptomics

Human cells typically transcribe half of their roughly 20,000 genes into RNA molecules at any given time. Just like with proteins, the function of those RNA species not only relies on their abundance but also their precise localization within the 3D space of each cell.

18 Mar 2021

New algorithm identifies 'escaping' cells in single-cell CRISPR screens

A team of researchers from New York has developed a new computational tool to help understand the function and regulation of human genes.

3 Mar 2021

New computational tool reveals the function and regulation of human genes

A new computational tool has been developed by a research team from New York to figure out the regulation and function of human genes.

2 Mar 2021

Compounds from marine-derived fungus may protect cells from paraquat

Biologically active compounds from the marine fungus Penicillium dimorphosporum protect cells from paraquat, the highly toxic herbicide with no remedy, and might enhance the action of some drugs.

24 Feb 2021

New method shows how pharmaceuticals induce cancer cell death

Cancer cells are smart when it comes to anti-cancer drugs, evolving and becoming resistant to even the strongest chemotherapies over time.

20 Jan 2021

Anti-hypertension drug prolongs lifespan in C. elegans, research shows

A stress response of mitochondria, the part of our cells that produce energy to power bodily functions, is important to a longer life.

21 Dec 2020

Newly identified diagnostic marker can help overcome treatment resistance in cervical cancer

Scientists from the University of California, Los Angeles have discovered a promising diagnostic marker that may help predict the response of cervical cancer patients to standard radiation and chemotherapy treatments.

14 Dec 2020

Study shows how microplastics are internalized into living cells

Microplastics have polluted the global environment. These minute particles enter food chains, and end up in the digestive systems of humans and animals.

11 Dec 2020

New method could more sensitively detect circulating tumor cells

Breast cancer is the most frequently diagnosed cancer in women, and metastasis from the breast to other areas of the body is the leading cause of death in these patients.

19 Nov 2020

Genetic predispositions affect the efficacy of COVID-19 drugs

A paper recently uploaded to bioRxiv* aimed to utilize genome-wide CRISPR screening to identify genes involved in modulating the activity of COVID-19 drugs.

29 Oct 2020

Experimental AI platform predicts best approach to cancer treatment

The U.S. Food and Drug Administration (FDA) has given final approval to only 4% of all cancer therapeutic drugs being developed.

26 Oct 2020

Irisin hormone could have therapeutic effect on COVID-19 patients

A study conducted by researchers at São Paulo State University (UNESP) suggests that irisin, a hormone secreted from muscles in response to exercise, could have a therapeutic effect on COVID-19 patients.

23 Sep 2020

Nanoparticle SARS-CoV-2 tool could accelerate the search for drugs

A team of scientists from the National Center for Advancing Translational Sciences and Naval Research Laboratory in Washington, D.C., has developed a new tool that mimics how SARS-CoV-2 -- the virus that causes COVID-19 -- infects a cell, information that could potentially speed the search for treatments against the disease.

22 Sep 2020

Study investigates how Ebola virus adapts to bat and human cells

A new study by researchers from The University of Texas Medical Branch at Galveston uncovered new information on why the Ebola virus can live within bats without causing them harm, while the same virus wreaks deadly havoc to people.

19 Aug 2020

Hudsonalpha researchers help elucidate functional elements of the genome

Although the Human Genome Project sequenced a nearly-complete human genome almost 20 years ago, only about two percent of the genes in the human genome have been extensively studied and identified as protein-coding genes. Proteins form the basis of living tissues and play a central role in biological processes.

3 Aug 2020

Researchers identify phosphoprotein biomarkers to guide cancer therapy

Precision medicine in cancer treatment uses genetic changes in the cancer cells to select the best therapies for individual patients.

29 Jul 2020

Olympus and Cytosurge collaborate to deliver a complete single-cell and CRISPR genetic manipulation solution in the Americas

Olympus, a leading manufacturer of high-end research microscopes, and Cytosurge, a precision manufacturer of cell manipulation technologies, have entered a co-marketing agreement to become a complete system provider to the scientific community’s growing need for next-generation single-cell and CRISPR genetic manipulation solutions.

From Cytosurge AG 29 Jul 2020

Computational tool can help study APA mechanism that regulates gene expression

Scientists keen on solving the regulation of genes implicated in human health and disease are widening their horizons by closely APA.

27 Jul 2020

Golgi membrane protein drives growth and invasion of breast cancer

The cover for issue 28 of Oncotarget features Figure 5, "TMEM165 expression levels alters N-linked glycosylation," by Murali, et al., and reported that the TMEM165 protein was not detected in non-malignant matched breast tissues and was detected in invasive ductal breast carcinoma tissues by mass spectrometry.

15 Jul 2020