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AMP Releases CYP3A4 and CYP3A5 Genotyping Assay Recommendations

The Association for Molecular Pathology (AMP), the world’s leading professional society for molecular diagnostics, released consensus recommendations today to aid in the design and validation of clinical CYP3A4 and CYP3A5 genotyping assays, encourage standardization of testing across labs, and better patient care.

11 Jul 2023

Research may Offer a New Way to Break Through Cancer's Hypoxia-Induced Defenses

For most of our tissues and cells, a lack of oxygen, or hypoxia, is bad news. Cancer cells, on the other hand, can thrive in these hypoxic conditions, which render tumors less susceptible to anti-cancer treatments, including radiation.

11 Jul 2023

Study Provides More Treatment Options for Severe COVID-19

Two anti-inflammatory drugs, abatacept and infliximab, reduced deaths among patients hospitalized with severe COVID-19, according to a national study led by Washington University School of Medicine in St. Louis.

11 Jul 2023

EMBL-EBI Launches Pathogens Portal to Enhance Global Pathogen Surveillance

EMBL's European Bioinformatics Institute (EMBL-EBI) has launched the Pathogens Portal – an online platform that enables researchers, clinicians, and policymakers to access the most comprehensive collection of biomolecular data about pathogens.

7 Jul 2023

T cells are Sensitive to Genetic Disturbances Within Mitochondrial Power Plants

All cells have their own power plants, called mitochondria. There are often more than 100 mitochondria per cell and each possesses their own genome, which in turn contains genes responsible for energy production.

7 Jul 2023

Study Reveals Key Insights Into the Evolution of Tumor Microenvironment in Gastric Cancer

A new study led by researchers at The University of Texas MD Anderson Cancer Center provides a deeper understanding of the evolution of the tumor microenvironment during gastric cancer progression.

7 Jul 2023

Synthetically Constructed Minimal Cell Shows That Life Finds a Way

"Listen, if there's one thing the history of evolution has taught us is that life will not be contained. Life breaks free.

6 Jul 2023

Study Uncovers Candidate Genes That may Drive Inflammatory Bowel Disease

A study of the genetic variation that makes mice more susceptible to bowel inflammation after a high-fat diet has identified candidate genes which may drive inflammatory bowel disease (IBD) in humans.

6 Jul 2023

Uncovering the Role of Cochlear Signal in Hearing Loss

A cochlear signal, the precise role of which has been uncertain since its discovery around 70 years ago, probably gives the brain information on whether the ear is working normally or not.

5 Jul 2023

Genetically Modified iPS Cell Applications for Fabry Disease

iPS cells have had a significant impact on biology and medicine, and they are expected to increase regenerative medicine. Clinical trials with various cell types derived from iPS cells have been performed since 2014 when a sheet of retinal pigment epithelial cells obtained from iPS cells was transplanted into patients with age-related macular degeneration.

4 Jul 2023

Mechanisms of MCL-1 Inhibitor-Induced MCL-1 Protein Upregulation and Induction of Apoptosis

A new editorial paper was published in Oncotarget's Volume 14 on June 21, 2023, entitled, "Decoding the mechanism behind MCL-1 inhibitors: A pathway to understanding MCL-1 protein stability."

29 Jun 2023

New Breakthrough of Genetic Marker Improves Treatment for Multiple Sclerosis

A study of more than 22,000 people with multiple sclerosis has discovered the first genetic variant associated with faster disease progression, which can rob patients of their mobility and independence over time.

29 Jun 2023

Analyzing the Role of Pyroptosis in Improving the Treatment of Lung Cancer

Lung cancer, one of the most aggressive forms of cancer, continues to be a leading cause of death worldwide. Although several new therapies have been developed for this disease, it has a poor prognosis in its advanced stages.

29 Jun 2023

Disclosing the Key Role of Mitofusin 2 Cellular Makeup in Interconnecting Organelles Within Cells

Researchers at IRB Barcelona, the University of Barcelona (UB), VIMM, and the University of Padua unveil the key role of Mitofusin 2 cellular makeup in interconnecting organelles within cells.

29 Jun 2023

Discovering a Major Factor Causing Aggressive Cancer

Researchers from the University of Otago have identified a crucial factor that contributes to the aggressive spread of colon cancer, marking a significant advancement in the fight against fatal tumors.

27 Jun 2023

New Computational Methods for Improving Alzheimer’s Disease Characterization

An improved method of subtyping Alzheimer’s disease based on genetic and tau PET imaging data has been developed computationally.

27 Jun 2023

Novel Drug Slows Development of Antibiotic Resistance

At the Baylor College of Medicine, a research group is gaining ground in its quest for solutions to the global concern of bacterial antibiotic resistance, which was accountable for almost 1.3 million deaths in 2019.

26 Jun 2023

Immune Deficits in Space are Temporary

An increase in proof has been found that astronauts are highly vulnerable to infections while in space. For instance, astronauts on board the International Space Station (ISS) generally suffer from skin rashes, and also respiratory and non-respiratory diseases.

23 Jun 2023

New Genetic Marker Could Predict Lenvatinib Resistance in Hepatocellular Carcinoma

A genetic marker discovered by UT Southwestern Medical Center researchers could help physicians predict which patients with hepatocellular carcinoma are most likely to develop resistance to the drug lenvatinib.

23 Jun 2023

Elaborate 3D Structures of DNA That Mimics Protein Functions

According to a study from scientists at Weill Cornell Medicine and the National Heart, Lung, and Blood Institute, a division of the National Institutes of Health, DNA can imitate protein activities by folding into complex, three-dimensional structures.

22 Jun 2023