DNA Damage News and Research

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ADAR1 protein offers a potential therapeutic target for cancer

A research team has discovered a new role of ADAR1 and found that the ADAR1p110 isoform controls genome stability at the ends of chromosomes.

15 Mar 2021

Targeted immunotherapy could improve radiotherapy response in cancer cells

Cancers that are resistant to radiotherapy could be rendered susceptible through treatment with immunotherapy, a new study suggests.

9 Mar 2021

A functional test to measure the effect of inherited gene variants in breast and ovarian cancer

Researchers at Mayo Clinic have combined results from a functional test measuring the effect of inherited variants in the BRCA2 breast and ovarian cancer gene with clinical information from women who received genetic testing to determine the clinical importance of many BRCA2 variants of uncertain significance (VUS).

22 Feb 2021

Antioxidant in green tea may lead to new anti-cancer drugs

Green tea contains an antioxidant that may boost the concentrations of p53, called the “guardian of the genome,” for its potential to kill cancerous cells.

15 Feb 2021

Cell cycle of cancer cells can be disrupted using two commercially available inhibitors

With two commercially available inhibitors, the cell cycle of the cancer cells in the childhood tumor neuroblastoma can be disrupted at a key point causing tumor cell death.

12 Feb 2021

Scientists detect genomic DNA changes even in sun-protected skin

Researchers have quantified the diverse types of genomic DNA variations that take place in skin cells and found that mutations from UV light is common.

15 Jan 2021

Study uncovers how shattered chromosomes make cancer cells more aggressive

Cancer is one of the world's greatest health afflictions because, unlike some diseases, it is a moving target, constantly evolving to evade and resist treatment.

From UC San Diego 24 Dec 2020

Scientists identify new protein that may improve future chemotherapy treatment

Chemotherapy not only attacks cancer cells but also targets all cells in the human body. This is the reason why patients receiving this treatment generally experience adverse side effects, like hair loss, physical weakness, and nausea.

18 Dec 2020

Researchers test effects of weedkiller on wildlife

Prolonged exposure to environmentally relevant concentrations of the weedkiller Roundup causes significant harm to keystone species according to new research at the University of Birmingham.

16 Dec 2020

Repair proteins can help healthy cells to avoid damage during cancer therapy

A key way radiation therapy and chemotherapy work is by making highly lethal double-strand breaks in the DNA of cancer cells.

10 Dec 2020

Research clarifies regulatory impacts of ubiquitin-proteasome system on DNA damage repair

An international research team has clarified the regulatory mechanism of the ubiquitin-proteasome system (*1) in recognizing and repairing DNA that has been damaged by ultraviolet (UV) light.

9 Dec 2020

Specialist microscope allows scientists to make one-molecule measurements

Researchers have designed and constructed a single-molecule specialist microscope, and shared the build instructions to help make this system available.

9 Nov 2020

Study examines how extremophilic microbes can tolerate drastic space conditions

Since the dawn of space exploration, humankind has been fascinated by survival of terrestrial life in outer space. Outer space is a hostile environment for any form of life, but some extraordinarily resistant microorganisms can survive.

5 Nov 2020

DNA structural changes play key role in the recovery phase after DNA damage

A research team from Cologne has discovered that a change in the DNA structure - more precisely in the chromatin - plays a decisive role in the recovery phase after DNA damage. The key is a double occupation by two methyl groups on the DNA packaging protein histone H3 (H3K4me2).

15 Oct 2020

A new protein discovered that repairs DNA

Researchers have identified a new protein that makes it possible to repair DNA. The protein in question is called cryptochrome.

15 Oct 2020

Novel mechanism restores cell function after DNA damage

Scientists have found that a modification in the DNA structure— specifically in the chromatin—plays a key role in the recovery stage following DNA damage.

15 Oct 2020

Risk for melanoma could be estimated by DNA mutation count

Risk for melanoma, the most deadly skin cancer, can be estimated long before detection of any suspicious moles, according to a UC San Francisco scientist who led a new study to detect DNA mutations in individual skin cells.

8 Oct 2020

Cancer mutations occur in distinct patterns based on 3D structure of the genome

A new study from researchers at The University of Texas MD Anderson Cancer Center has discovered that mutations found in cancers do not accumulate randomly, but are found in distinct patterns that vary based on the three-dimensional organization of the genome in the cell as well as the underlying factors causing the mutations.

6 Oct 2020

Epigenetic alterations drive late-onset Alzheimer's disease

New findings suggest that late-onset Alzheimer's Disease is driven by epigenetic changes -- how and when certain genes are turned on and off -- in the brain. Results were published today in Nature Genetics.

29 Sep 2020

New precision drug targeting cancer's ability to repair DNA shows promise

A new precision drug which stops cancer from repairing its DNA has shown promise in an early-stage clinical trial - highlighting the potential of a new class of drugs known as ATR inhibitors.

29 Sep 2020