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Understanding molecular determinants of liver cancer in patients with Indigenous American ancestry

Oncotarget published "Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry" which reported that contrasting with this pattern, the age structure of HCC in Andean people displays a bimodal distribution with half of the patients developing HCC in adolescence and early adulthood.

2 Jun 2021

First real-time observation of DNA-histone interactions

The genetic material of most organisms is carried by DNA, a complex organic molecule. DNA is very long -- for humans, the molecule is estimated to be about 2 m in length.

2 Jun 2021

Genetic differences within microalgal symbionts relate to the coral species they inhabit

The microscopic algae that live inside and provide nutrients to their reef-building coral hosts may be evolving in tandem with the corals they inhabit, so each partner is fine-tuned to meet one another's needs.

From Penn State University 1 Jun 2021

New study shows why some children get secondary leukemia after neuroblastoma treatment

Researchers from the Wellcome Sanger Institute and the University of Cambridge discovered that in children with neuroblastoma—a tumor of immature nerve cells—platinum chemotherapy created mutations in the genome that might lead to leukemia in some children later on.

31 May 2021

Researchers discover a new, effective way to treat aggressive blood cancer in children

Australian scientists have found what could prove to be a new and effective way to treat a particularly aggressive blood cancer in children.

31 May 2021

Genetic editing tools stop the spread of Culex mosquitoes

Since the onset of the CRISPR genetic editing revolution, scientists have been working to leverage the technology in the development of gene drives that target pathogen-spreading mosquitoes such as Anopheles and Aedes species, which spread malaria, dengue and other life-threatening diseases.

From UC San Diego 31 May 2021

Researchers discover new genes and functionalities in bovine genome

Modern genetic research often works with what are known as reference genomes. Such a genome comprises data from DNA sequences that scientists have assembled as a representative example of the genetic makeup of a species.

27 May 2021

Genomic study can reveal adaptive mechanisms of life under future ocean acidification

Human-driven global change is challenging the scientific community to understand how marine species might adapt to predicted environmental conditions in the near-future (e.g. hypoxia, ocean warming, and ocean acidification).

27 May 2021

New software tool detects, evaluates, and quantifies off-target editing activity

CRISPR technology enables researchers to edit genomes by modifying DNA sequences and hence gene function.

27 May 2021

Researchers prove that drugs designed for bacteria have the potential to act on human cells

Antibiotics used to treat common bacterial infections may potentially be used to treat human illnesses such as cancer, at least theoretically.

27 May 2021

Two components of bacterial CRISPR-Cas immunity system are physically linked

Skoltech scientists have demonstrated that the two components of the bacterial CRISPR-Cas immunity system are physically connected.

27 May 2021

Genetic and molecular mechanisms make chemotherapy drug work for some cancer patients

The chemotherapy drug decitabine is commonly used to treat patients with blood cancers, but its response rate is somewhat low. Researchers have now identified why this is the case, opening the door to more personalized cancer therapies for those with these types of cancers, and perhaps further afield.

25 May 2021

Study could help develop peptide siRNA carrier for human oral cancer

MUSC Hollings Cancer Center researchers are exploring the use of peptide carriers for the delivery of small RNA drugs as a novel treatment for cancer. The team's recent work, published online March 19 in the Molecular Therapy - Nucleic Acids journal, lays the foundation for developing a clinically relevant peptide carrier RNAi-based drug treatment strategy for human oral cancer.

25 May 2021

“Paralyzed” immune cells can be reactivated by drugs in IDH-mutant gliomas

Brain tumor cells with a certain common mutation reprogram invading immune cells. This leads to the paralysis of the body's immune defense against the tumor in the brain. Researchers from Heidelberg, Mannheim, and Freiburg discovered this mechanism and at the same time identified a way of reactivating the paralyzed immune system to fight the tumor.

25 May 2021

Plant-based technology reveals key process in virus infection cycle in dynamic detail

A critical process in the infection cycle of viruses has been revealed for the first time in dynamic detail using pioneering plant-based technology.

25 May 2021

Environmental DNA helps track down species on the move

Many individuals would like to prevent sloughed-off skin and bodily fluids. However, for marine biologists like Cheryl Lewis Ames, Associate Professor of Applied Marine Biology in the Graduate School of Agricultural Science at Tohoku University (Japan), such life remnants have become a magical guide to detecting the unseen.

24 May 2021

Genetic News and Research

Understanding molecular determinants of liver cancer in patients with Indigenous American ancestry

First real-time observation of DNA-histone interactions

Genetic differences within microalgal symbionts relate to the coral species they inhabit

New study shows why some children get secondary leukemia after neuroblastoma treatment

Researchers discover a new, effective way to treat aggressive blood cancer in children

Genetic editing tools stop the spread of Culex mosquitoes

Researchers discover new genes and functionalities in bovine genome

Genomic study can reveal adaptive mechanisms of life under future ocean acidification

New software tool detects, evaluates, and quantifies off-target editing activity

Researchers prove that drugs designed for bacteria have the potential to act on human cells

Two components of bacterial CRISPR-Cas immunity system are physically linked

Genetic and molecular mechanisms make chemotherapy drug work for some cancer patients

Study could help develop peptide siRNA carrier for human oral cancer

“Paralyzed” immune cells can be reactivated by drugs in IDH-mutant gliomas

Plant-based technology reveals key process in virus infection cycle in dynamic detail

Environmental DNA helps track down species on the move

New genetic pathway plays a critical role in the ripening of tomatoes

Three-dimensional organization of genome is extremely dynamic during gamete formation

Study shows how mitochondrial function impacts schizophrenia in patients with genetic disorder

Study identifies predictive causal role for specific cell types in type 1 diabetes

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