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New CRISPR technology allows scientists to switch off any gene in human cells

Scientists have figured out how to modify CRISPR's basic architecture to extend its reach beyond the genome and into what's known as the epigenome -- proteins and small molecules that latch onto DNA and control when and where genes are switched on or off.

19 Apr 2021

“Expansion Hunter” approach can detect DNA errors

Researchers from Radboud University Medical Center have successfully detected hidden genetic defects by using an existing technique on existing datasets. The team demonstrated that the “Expansion Hunter” approach can detect DNA errors that cause repeat expansion diseases, like ataxia—a movement disorder.

16 Apr 2021

Researchers use information embedded in microbial genes as a biosensor of ocean health, productivity

Scientists from the University of California, Irvine, analyzed gains and losses in the genes of phytoplankton samples gathered from all major ocean regions to develop the most refined and highest-resolution map that shows where these photosynthetic organisms either survive or are forced to adapt to restricted amounts of main nutrients, nitrogen, iron, and phosphorus.

16 Apr 2021

Study reveals RNA regulatory mechanisms within transcription-translation couplings

To gain a better understanding of how bacterial RNA gives rise to proteins scientists are now focusing on the special way this process takes place in bacteria.

15 Apr 2021

Ebola virus protein changes shape by using human RNA

The human genome contains the instructions to make tens of thousands of proteins. Each protein folds into a precise shape--and biologists are taught that defined shape dictates the protein's destined function. Tens of thousands of singular shapes drive the tens of thousands of needed functions.

15 Apr 2021

Scientists characterize the genetic diversity of populations in the South Pacific

Describing the genetic diversity of human populations is essential to improve our understanding of human diseases and their geographical distribution.

From Institut Pasteur 15 Apr 2021

Study reveals DNA supercoiling is involved in regulating gene expression

The (when stretched) two-meter-long DNA molecule in each human cell is continuously being unpacked and packed again to enable the expression of genetic information.

15 Apr 2021

New method helps map the epigenetics of mouse brain

Histones are essentially small proteins that attach to DNA and store information that can be used to switch individual genes on or off.

14 Apr 2021

Novel test detects HIV reservoir in patients more accurately

An innovative test that determines the quality and quantity of inactive HIV viruses in the genes of HIV patients may ultimately give scientists a better idea of effective drugs.

14 Apr 2021

New simpler, faster system for analyzing mutations in SARS-CoV-2

Although it is known that mutations in the SARS-CoV-2 genome occurred and spread, the effect of those mutations is not yet clear.

From Osaka University 14 Apr 2021

CSHL investigator aims to predict the effects of mutations on different tomato varieties

Both people and tomatoes come in different shapes and sizes. That is because every individual has a unique set of genetic variations--mutations--that affect how genes act and function. Added together, millions of small genetic variations make it hard to predict how a particular mutation will impact any individual.

13 Apr 2021

Study reveals genetic risk factors for childhood obsessive-compulsive disorder

Researchers at the University of Calgary and The Hospital for Sick Children (SickKids), in Toronto, have discovered genetic risk factors for OCD that could help pave the way for earlier diagnosis and improved treatment for children and youth.

13 Apr 2021

Obesity reduces mitochondrial gene expression in fat tissues

A university has recently completed a study that suggests that the machinery responsible for handling the energy in fat tissues is performing poorly in obesity.

12 Apr 2021

Mitochondrial DNA mutations reduce death risk in patients with bowel cancer

According to a study, DNA defects in the energy “factories” of a cell increase the chance of survival in patients suffering from bowel cancer.

9 Apr 2021

Researchers discover new species of bumblebee through genome sequencing

Scientists have discovered a new species of bumblebees while investigating genetic diversity in bumblebees in the Rocky Mountains, United States.

8 Apr 2021

PNA-based method is a key component of the gene editing toolkit

The Somatic Cell Gene Editing Consortium has given an update on the status of their initiative to design safer techniques to edit the genes of disease-relevant somatic cells.

8 Apr 2021

Fossil skull of a woman provides the oldest reconstructed modern human genome to date

Ancient DNA from Neanderthals and early modern humans has recently shown that the groups likely interbred somewhere in the Near East after modern humans left Africa some 50,000 years ago. As a result, all people outside Africa carry around 2% to 3% Neanderthal DNA.

8 Apr 2021

Study discovers how some proteins ensure repair of errors introduced during DNA replication

Researchers have discovered how specific proteins ensure the rectification of errors introduced into the DNA when it replicates.

7 Apr 2021

Japanese consumers have more negative opinions about gene-editing of livestock, survey finds

A statistically rigorous survey of Japanese consumers has found that they have more negative opinions about the use of new gene-editing techniques on livestock than they do about use of the same technologies on vegetables.

7 Apr 2021

High ozone concentrations decrease crop yield in maize

Although stratospheric ozone protects us by filtering out the sun's ultraviolet radiation, tropospheric ozone is a harmful pollutant. A new study has shown that ozone in the lower layers of the atmosphere decreases crop yields in maize and changes the types of chemicals that are found inside the leaves.

7 Apr 2021

Genome News and Research

New CRISPR technology allows scientists to switch off any gene in human cells

“Expansion Hunter” approach can detect DNA errors

Researchers use information embedded in microbial genes as a biosensor of ocean health, productivity

Study reveals RNA regulatory mechanisms within transcription-translation couplings

Ebola virus protein changes shape by using human RNA

Scientists characterize the genetic diversity of populations in the South Pacific

Study reveals DNA supercoiling is involved in regulating gene expression

New method helps map the epigenetics of mouse brain

Novel test detects HIV reservoir in patients more accurately

New simpler, faster system for analyzing mutations in SARS-CoV-2

CSHL investigator aims to predict the effects of mutations on different tomato varieties

Study reveals genetic risk factors for childhood obsessive-compulsive disorder

Obesity reduces mitochondrial gene expression in fat tissues

Mitochondrial DNA mutations reduce death risk in patients with bowel cancer

Researchers discover new species of bumblebee through genome sequencing

PNA-based method is a key component of the gene editing toolkit

Fossil skull of a woman provides the oldest reconstructed modern human genome to date

Study discovers how some proteins ensure repair of errors introduced during DNA replication

Japanese consumers have more negative opinions about gene-editing of livestock, survey finds

High ozone concentrations decrease crop yield in maize

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