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Drugs used for myelodysplastic syndrome could potentially activate a sleeping oncogene

Hypomethylating agents (HMA) are currently used as a first-line treatment for patients with myelodysplastic syndrome (MDS) - a group of disorders where there is insufficient production of healthy mature blood cells in the bone marrow - and increasingly in other diseases, but their mechanism of action remains unclear.

From National University of Singapore (NUS) 27 May 2022

Reducing the amount of protein in diet produces an array of favorable health outcomes, study says

The lifespan extension caused by a low-protein diet appears to be coordinated by a single hormone.

18 May 2022

Scientist reveals the impact of mitochondria in metastatic prostate cancer

Prostate cancer that has spread to other regions of the body is commonly treated with hormone treatment, but many individuals develop resistance to it, making their disease more aggressive and potentially fatal.

12 May 2022

Study shows serum-derived extracellular vesicles may help in diagnosing amyloidosis

Amyloidosis is a term used to describe a group of diseases defined by the formation of insoluble proteins called amyloids outside of cells as a result of misfolding and aggregation of soluble proteins.

12 May 2022

Study explains how liver regeneration may help treat liver disease in mice

Other vertebrates, such as fish and lizards, can regenerate organs more effectively than mammals. Salk researchers have discovered a mechanism to partially restore the young condition of liver cells, allowing them to repair damaged tissue at a quicker rate than previously thought.

29 Apr 2022

CN Bio introduces PhysioMimix NASH ‘in-a-box’ reagent kit

First product within new ‘in-a-box’ range, which harnesses next-generation, human-relevant Liver-on-a-Chip technology to improve the accuracy and efficiency of NASH drug discovery.

From CN Bio Innovations Limited 26 Apr 2022

New protective mechanism against non-alcoholic fatty liver disease identified

Non-alcoholic fatty liver disease (NAFLD), commonly known as fatty liver disease, is a prevalent disease frequently seen in obese people. Having high fat content in the liver is detrimental as it is strongly associated with severe health problems like diabetes, high blood pressure, and liver cancer.

20 Apr 2022

Research associates autophagy and age-related nervous system degradation

The in-built mechanism of recycling dead or poisonous material to preserve the health of human cells is critical to general health.

20 Apr 2022

Combining organoids and microfluidics to study how the immune system responds to hepatitis C

A vaccine for hepatitis C has eluded scientists for more than 30 years, for several reasons. For one, the virus that causes the disease comes in many genetic forms, complicating the creation of a widely effective vaccine.

7 Apr 2022

Breakthrough discovery provides a desirable drug target to tackle metabolic diseases

In a breakthrough discovery, scientists from The University of Texas Health Science Center at San Antonio today reported that inhibiting a liver enzyme in obese mice decreased the rodents' appetite, increased energy expenditure in adipose (fat) tissues and resulted in weight loss.

6 Apr 2022

Experimental "gene silencing" therapy reduces a important driver of heart disease risk by up to 98%

Findings from a new Cleveland Clinic-led phase 1 trial show that an experimental "gene silencing" therapy reduced blood levels of lipoprotein(a), a key driver of heart disease risk, by up to 98%.

4 Apr 2022

Study explores that extra dosages of genes may lead to surplus X chromosomes

One out of every 500 to 1,000 boys is born with one or more extra X chromosomes, which can cause a variety of symptoms as the extra chromosomes to including infertility, larger breasts, osteoporosis, diabetes, cardiac problems, intellectual incapacity, and cancer.

1 Apr 2022

Globins in the body help fight liver disease

Anti-fibrotic therapy is still a medical necessity in the treatment of chronic liver disease in humans. The anti-fibrotic activity of globin family members in hepatic stellate cells (HSCs), the principal cell type involved in liver fibrosis, was reported by a research group led by Professor Norifumi Kawada of Osaka Metropolitan University (OMU).

24 Mar 2022

Novel mechanistic insight into how gut bacteria work to tame intestinal inflammation

Bile acids made by the liver have long been known for their critical role in helping to absorb the food we ingest.

From Harvard Medical School 17 Mar 2022

New tools for measuring the biological ages of various organ systems

It's common to say that someone looks either younger or older than their chronological age, but aging is more than skin deep.

9 Mar 2022

T cells sometimes remain in the skin for years, research finds

Human immune cells not only circulate in the blood, but can also occupy certain tissues and sometimes remain there for years.

8 Mar 2022

Threespine stickleback fish study details how parasite resistance in hosts arises

They thrive everywhere from bustling cities to remote rainforests -; even in our own backyards. Pervasive and unapologetic mooches, parasites rely on other organisms for their survival.

3 Mar 2022

Intestinal cell changes are driven by the BMP signaling pathway, study finds

Intestinal cells can change specializations during their lives. The BMP signaling pathway – an important communication mechanism between cells – appears to be the driver of these changes.

2 Mar 2022

Microbes hindering cancer therapy seem to play a bigger role than helpful ones

Melanoma patients receiving therapy that helps their immune system kill cancer cells respond to treatment differently depending on the types of microbes in their gut, and new research suggests the microorganisms hindering therapy have more influence than the beneficial ones.

1 Mar 2022

Researchers create a regulatory map of zebrafish genome

The zebrafish is an important model organism for studying things like genetic diseases. A regulatory map of its genome has been successfully created using high-throughput experiments and AI methods, a team led by Uwe Ohler now reports in Cell Genomics and Nature Machine Intelligence.

25 Feb 2022